Integrated Glucagon Model for Estimation of Alpha-cell Responsivity to Glucose and Amino Acids During Graded Glucose Infusion [0.03%]
分级葡萄糖输注过程中整合的胰高血糖素模型以估算α细胞对葡萄糖和氨基酸的反应能力
Federica Boscolo,Sneha Mohan,Marcello C Laurenti et al.
Federica Boscolo et al.
Pancreatic α-cells secrete glucagon. The glucagon secretion rate (GSR) increases when plasma glucose decreases; conversely, GSR decreases when glucose rises. In addition, amino acids (AA) stimulate GSR. Impaired GSR suppression by glucose ...
Effects of acute and recurrent clamp-induced hypoglycemia on resting metabolic rate in healthy adults [0.03%]
健康成年人一次性和复发性夹板致低血糖对基础代谢率的影响
Daniel Malmsiø,Johan Onslev,Jørgen Wojtaszewski et al.
Daniel Malmsiø et al.
Background: Hypoglycemia is a common and serious side effect to insulin treatment, which has been studied extensively. However, resting metabolic rate during hypoglycemia, and its potential adaptions to recurrent hypoglycemia, has not been ...
Marlon R Schneider
Marlon R Schneider
This manuscript addresses a fundamental but previously unquantified aspect of mammalian physiology: the energetic cost of a continuous peripheral lipid export pathway. By integrating dermatological measurements with whole-body energy budget...
Immunometabolism of IRF4 in Adipose, Muscle, and Immune Cells Influences Obesity and MASLD [0.03%]
IRF4在脂肪细胞、肌肉细胞和免疫细胞中的免疫代谢影响肥胖和MASLD
Daniel M Marko,Jonathan D Schertzer
Daniel M Marko
Interferon regulatory factor 4 (IRF4) connects immunity and metabolism in immune cells and parenchymal cells of metabolic tissues. In immune cells, IRF4 is a metabolic rheostat that promotes glycolysis to support macrophage polarization and...
Is High Insulin Protective or Detrimental? Mathematical Modeling Reveals the Base of the Iceberg [0.03%]
高胰岛素是保护性的还是破坏性的？数学建模揭示冰山一角的基础
Boya Yang,Joon Ha,Arthur S Sherman
Boya Yang
Type 2 diabetes (T2D) progression involves complex interactions over time, yet longitudinal human data remain limited. Mathematical modeling enables reconstruction of individualized disease trajectories and mechanistic insights from sparse ...
Gut Microbiota Transplantation from Young Adult Mice Fails to Restore Low Bone and Muscle Mass in Old Mice [0.03%]
年轻小鼠的肠道微生物移植不能恢复老年小鼠的低骨量和肌肉量
Lina Lawenius,Daniel Hägg,Karin Horkeby et al.
Lina Lawenius et al.
Aging is associated with reduced lean and bone mass, as well as alterations in gut microbiota composition. We previously demonstrated that gut microbiota composition differs between young adult and old mice, and that transplanting gut micro...
Higher hemoglobin levels within reference interval are associated with elevated cardiometabolic traits in a birth-cohort of 16-year-old adolescents [0.03%]
在一项针对16岁青少年的出生队列研究中，参考范围内的较高血红蛋白水平与心血管代谢特征升高有关
Joona Tapio,Samuli Sakko,Johannes Kettunen et al.
Joona Tapio et al.
Hemoglobin (Hb) levels are commonly measured to assess health and oxygen transport. While levels outside the reference interval indicate anemia or polycythemia, higher Hb levels within the referenced interval have been linked to adverse car...
Acute Interleukin-1ß antagonism decreases systemic inflammation, increases GLP-1 release and modulates insulin secretion in individuals with prediabetes [0.03%]
急性拮抗IL-1β可减轻炎症、增加胰高血糖素样肽-1的释放并调节糖尿病前期人群的胰岛素分泌
Justus S Fischer,Matthias Hepprich,Marco Cattaneo et al.
Justus S Fischer et al.
Metabolic stress in obesity and diabetes activates innate immunity. Chronic IL-1β antagonism improves insulin secretion in type 2 diabetes. However, it is unclear how rapidly this effect occurs, whether it is also present in individuals wi...
Impact of nesting materials on energy balance in male C57BL/6J mice exposed to different ambient temperatures [0.03%]
窝料对不同环境温度下雄性C57BL/6J小鼠能量平衡的影响
Sarra Beji,Mylène Bastien,Alexandre Caron
Sarra Beji
Nesting materials are used to enhance animal welfare in laboratory settings, yet their physiological impact, particularly on energy metabolism, remain under-characterized. Here, we investigated the effect of three commonly used nesting mate...
Cardiometabolic and Metabolic Profiles in Irritable Bowel Syndrome Associated with Type 2 Diabetes [0.03%]
与2型糖尿病相关的肠易激综合征的心血管代谢和代谢特征
Franziska Schmelter,Lotta Nowak,Paul Beier et al.
Franziska Schmelter et al.
Irritable bowel syndrome (IBS), a common disorder of gut-brain interaction, has been increasingly associated with metabolic dysfunction and cardiometabolic risk. This study aimed to comprehensively assess cardiometabolic risk factors in ind...