Sex differences in exogenous glucose oxidation are attenuated by obesity: Insights from a [U-¹³C₆]glucose home breath test [0.03%]
性别差异通过家庭呼吸试验在家用[U-¹³C₆]葡萄糖中的外源性葡萄糖氧化作用减弱：肥胖的见解
Stephanie Estafanos,Daniel West,Anessa Koussiouris et al.
Stephanie Estafanos et al.
Biological sex influences whole-body glucose metabolism, with females generally displaying greater insulin sensitivity than males, yet paradoxically similar or poorer glucose tolerance when assessed with oral glucose tolerance tests (OGTTs)...
Mechanisms of norepinephrine induced Ca2+ responses in perivascular adipose tissue [0.03%]
去甲肾上腺素诱导血管外膜脂肪组织钙离子反应的机制研究
Julia R Jamka,Emma D Flood,William F Jackson et al.
Julia R Jamka et al.
Structural changes in microcirculation are often considered the first signs of vascular damage due to hypertension. A key tissue type emerging as a regulator of vascular tone is perivascular adipose tissue (PVAT). PVAT is a complex collecti...
Generation of Ucp1-ires-Cre knock-in mice to enhance specificity and efficiency of gene targeting in brown adipose tissue [0.03%]
生成Ucp1-ires-Cre敲入小鼠以增强棕色脂肪组织中基因靶向的特异性和效率
Jen-Ying Hsu,Wen-Hsin Lu,Yu-Ya Chang et al.
Jen-Ying Hsu et al.
Brown adipose tissue (BAT) secretes cytokines that influence the function of other tissues. Given the widespread distribution of brown fat depots, we generated BAT-lacking (ΔBAT) mouse models by specifically eliminating brown adipocytes us...
Testosterone administration partially modulates gut microbiota responses to severe energy deficit [0.03%]
睾酮调节严重能量亏损的肠道微生物群反应的部分作用
Alex E Mohr,Claire E Berryman,Melissa N Harris et al.
Alex E Mohr et al.
Severe diet- and exercise-induced energy deficit (SED) suppresses androgen production in healthy men, altering metabolism and driving muscle loss. The gut microbiota modulates host metabolism, yet the community's response to SED and any rol...
The interaction between glucose levels and body mass index on the regulation of circulating sphingolipidome in humans [0.03%]
血糖水平与体质指数在人类循环鞘脂组学调节中的相互作用
Camillo Morano,Lucia Centofanti,Michele Dei Cas et al.
Camillo Morano et al.
Background. Circulating sphingolipids have been associated with diabetes risk and chronic complications. This study characterized the sphingolipidome in a subset of the CA.ME.LI.A. cohort to identify lipid signatures related to sex, body ma...
Maternal exercise during lactation remodels obesity-associated mammary metabolism and milk fatty acids, enhancing offspring lipid oxidation [0.03%]
哺乳期母体运动重塑肥胖相关乳腺代谢及乳脂肪酸，增强后代脂质氧化
Gertrude Kyere-Davies,Kaitlyn B Hill,Gregory P Mullen et al.
Gertrude Kyere-Davies et al.
Maternal obesity alters breast milk composition in ways that may predispose infants to excess adiposity. While maternal exercise during lactation has been associated with favorable shifts in milk metabolites in humans, the mechanisms by whi...
Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals [0.03%]
大麻素受体调节剂在健康人连续高血糖和等血糖高胰岛素钳夹试验中的急性代谢效应
Chee W Chia,Eric Y Tang,Roy G Cutler et al.
Chee W Chia et al.
The endocannabinoid system is involved in a vast array of physiological processes including regulating metabolism through insulin secretion and action. In this physiological study of twenty-one healthy men, we investigated the acute effects...
Dissociation Between Metabolic Improvements and Mitochondrial Transcriptional Changes Following Exercise Training in Women with Polycystic Ovary Syndrome [0.03%]
多囊卵巢综合征女性运动训练后的代谢改善与线粒体转录变化相分离的现象
Alba Moreno-Asso,Ali Altıntaş,Sarah Voisin et al.
Alba Moreno-Asso et al.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder associated with insulin resistance and affecting women of reproductive age. Although the aetiology and the underlying molecular mechanisms of metabolic dysregulation in PCOS...
Acute metabolic and molecular responses to sprint interval versus moderate-intensity continuous exercise in healthy young men [0.03%]
关于健康年轻男性高强度间歇训练和中等强度持续训练的急性代谢及分子反应的对比研究
Enda Murphy,Claire Laurens,Laurie Frances et al.
Enda Murphy et al.
Background: Exercise intensity is a key determinant of the physiological responses in skeletal muscle that lead to improvements in human health. Whether a bout of brief supramaximal acute exercise has similar effects on muscle physiology an...