Chemogenetic placental activation and proteomic extracellular vesicle signatures predict functional roles across pregnancy and postpartum [0.03%]
化学遗传性胎盘激活和蛋白质组外泌体信号预测妊娠期和产后功能角色
Geoffrey A Dunn,Arthur S Feltrin,Rodrigo Orso et al.
Geoffrey A Dunn et al.
Mechanisms underlying homeostatic regulation of maternal health during pregnancy and the postpartum period are critical yet remain understudied. Extracellular vesicles (EVs) are vital sources of cell-to-cell communication that maintain home...
Branched chain and glucogenic amino acids predict brown fat recruitment and metabolic clearance in adults with overweight or obesity [0.03%]
支链和生糖氨基酸可预测超重或肥胖成年人的棕色脂肪募集及代谢清除率
Lijuan Sun,Hui Jen Goh,Xinyan Bi et al.
Lijuan Sun et al.
The relationship between circulating amino acids (AAs), particularly branched-chain amino acids (BCAAs) and brown adipose tissue (BAT) recruitment and their subsequent fate during thermogenesis remains poorly defined. We investigated the lo...
Gut Microbiota-Generated Trimethylamine N-Oxide from Dietary Choline and Glucose Homeostasis in Humans [0.03%]
膳食胆碱通过肠道菌群生成三甲胺-N-氧化物与人体糖代谢的关系
Eleni Laskaridou,Cortney N Steele,Glen R Reid et al.
Eleni Laskaridou et al.
The causal relationship between gut microbiota-generated trimethylamine N-oxide (TMAO) and type 2 diabetes remains unclear. We tested the hypothesis that gut microbiota-generated increases in plasma TMAO concentrations will impair insulin s...
Glutamine metabolism shapes the phenotypic adaptation of uterine dendritic cells in response to early allogeneic pregnancy [0.03%]
谷氨酰胺代谢调控子宫树突状细胞在同种异体妊娠早期的表型适应性变化
Songchen Cai,Agnes Wieczorek,Christopher Urbschat et al.
Songchen Cai et al.
The impact of metabolic reprogramming on immune cell functions is increasingly recognized. However, it remains largely unexplored in terms of immune cells adaptation during reproduction. Dendritic cells (DC) are crucial for establishing and...
ATF3 in Metabolic Homeostasis and Vascular Disease: Integrating Bibliometric Evidence with Therapeutic Potential [0.03%]
ATF3在代谢稳态和血管疾病中的作用：文献计量证据与治疗潜力的整合研究
Heng Lin,Hsi-Hsien Chen,Yu-Pei Lin et al.
Heng Lin et al.
Activating transcription factor 3 (ATF3) functions as a central regulator of metabolic homeostasis across multiple physiological systems. A bibliometric analysis of ATF3 research (1993-2025) demonstrates an exponential growth trend, particu...
Liver and Kidney Crosstalk - Liver-derived Bile Acids and Kidney Water Retention [0.03%]
肝肾对话-肝脏生成的胆酸和肾脏水潴留
Amanda Lynggaard Elkjær,Iben Skov Jensen,Mads Gabriel Tiddy et al.
Amanda Lynggaard Elkjær et al.
Edema formation and ascites are common features in liver disease. The excessive accumulation of body water is caused by increased kidney water retention; yet the mechanisms linking liver and kidney function remain incompletely understood. T...
Placental discrepancies between Black and White preeclampsia patients in a Southeastern USA cohort [0.03%]
美国东南部地区患有子痫前期的黑人和白人妇女胎盘差异性研究
Madison Ives,Gibson Cooper,Cayman Bickerstaff et al.
Madison Ives et al.
Preeclampsia is a devastating hypertensive disorder of pregnancy with a high prevalence in the southern regions of the United States. Black pregnant patients are disproportionally at higher risk for preeclampsia onset and severity of diseas...
The effect of ghrelin on insulin sensitivity and beta-cell function after sleeve gastrectomy [0.03%]
胃袖状切除术后ghrelin对胰岛素敏感性及β细胞功能的影响
Marie-Louise Dichman,Nora Hedbäck,Amalie London et al.
Marie-Louise Dichman et al.
Aims: Sleeve gastrectomy (SG) leads to substantial weight loss and improvement in type 2 diabetes, but the underlying mechanisms remain incompletely understood. Given that circulating ghrelin concentrations are reduced after SG; we hypothes...