PYY3-36 potentiates Semaglutide‑mediated mitochondrial modulation in MASLD [0.03%]
PYY3-36增强Semaglutide介导的MASLD中线粒体调节作用
Niklas Geiger,Alexander Georg Nickel,Michael Kohlhaas et al.
Niklas Geiger et al.
Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent comorbidity of obesity. Incretins have emerged as promising therapeutics for MASLD, but their exact mechanisms of action remain un...
Single-cell dissection of cholesterol metabolism reveals cell-type-specific genes and hypercholesterolemia-associated remodeling [0.03%]
单细胞分析胆固醇代谢鉴定出特定类型细胞的基因及高胆固醇血症相关的重塑现象
Jian Chu,Jing Zhuang,Shuwen Han et al.
Jian Chu et al.
Objective: This study was aimed at systematically characterizing cell-type-specific cholesterol metabolism in human blood samples, and investigating the impact of hypercholesterolemia on the composition and gene expression of immune and str...
Hypothalamic-Pituitary-Gonadal Axis Programming and Disrupted Ovarian-Endocrine Function in Female Offspring of the Preeclamptic-Like BPH/5 Mouse [0.03%]
妊娠期高血压模型BPH/5鼠后代下丘脑-垂体-性腺轴的程序调控和卵巢内分泌功能异常
Victoria N Bailey,Kendall R Ball,Kalynn E Grandberry et al.
Victoria N Bailey et al.
Children born after preeclampsia, the leading hypertensive disorder of pregnancy, are predisposed to long-term cardiometabolic and reproductive disorders that are likely associated with prenatal exposure to a dysregulated maternal endocrine...
Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a pre-clinical model of colorectal cancer by biological sex [0.03%]
癌症和化疗引起的恶病质的差异影响：通过生物学性别对结直肠癌临床前模型进行比较分析
Ana Regina Cabrera,Eleanor R Schrems,Ruqaiza Muhyudin et al.
Ana Regina Cabrera et al.
Cancer cachexia is a wasting condition characterized by muscle loss and reduced quality of life in cancer patients. Although biological sex differences in the progression of cancer cachexia have been increasingly recognized, their role duri...
The Role of β-Klotho in FGF Signaling: From Molecular Insights to Therapeutic Innovations [0.03%]
β-肾上腺髓质素在FGF信号转导中的作用：从分子见解到治疗创新
Fang Yan,Chen Yang,ShiYuan Huang et al.
Fang Yan et al.
β-Klotho (KLB) is a transmembrane protein expressed in the liver, pancreas, hypothalamus, and adipose tissue, where it acts as an essential co-receptor for fibroblast growth factor 19 (FGF19) and FGF21. By facilitating their binding to fib...
Bridging the gap: Multi-omic Insights into Exercise Responses in Post-Menopausal Women [0.03%]
弥合差距：后menopausal女性运动反应的多组学见解
Rushali Kullachanda Aiyanna,Sisi Wang,Robin Grolaux et al.
Rushali Kullachanda Aiyanna et al.
Post-menopausal women represent the fastest-growing demographic at risk of sarcopenia and cardiometabolic disease, yet exercise biology research remains disproportionately derived from male or hormone-replete phenotypes. Menopause constitut...
Low oxygen availability induces a metabolic shift towards enhanced glucose utilization in non-lipid-loaded and lipid-loaded HepG2 cells [0.03%]
低氧诱导的代谢重编程促进非脂质和负载脂质肝细胞中糖酵解增强
Geng Li,Ludwig J Dubois,Rianne Biemans et al.
Geng Li et al.
Liver function is impaired in metabolic dysfunction-associated fatty liver disease. Previous studies demonstrated that oxygen availability in the tissue microenvironment affects adipose tissue and skeletal muscle function, but its hepatic e...
Obesity-Related Circulating Endothelial Extracellular Vesicles Negatively Affect Cerebral Microvascular Cell Function [0.03%]
肥胖相关循环内皮细胞外囊泡对脑微血管细胞功能的影响作用研究
Samuel T Ruzzene,Vinicius P Garcia,Auburn R Berry et al.
Samuel T Ruzzene et al.
The aim of this study was to determine, in vitro, the effect of endothelial cell-derived extracellular vesicles (EEVs) from adults with obesity on brain microvascular endothelial cell nitric oxide (NO) and endothelin (ET)-1 production as we...
Nitrate and resveratrol supplementation selectively enhances hepatic adaptations to aerobic exercise in high-fat fed male mice [0.03%]
硝酸盐和白藜芦醇补充选择性地增强了高脂喂养雄性小鼠有氧运动的肝脏适应能力
Rachel M Handy,Geneviève J DesOrmeaux,Sandra Guga et al.
Rachel M Handy et al.
Aerobic exercise training (AET) and numerous dietary interventions, including nitrate and resveratrol supplementation, display overlapping mechanisms affecting mitochondrial bioenergetics and metabolism in diverse tissues. However, it remai...