An AMPK/Axin1-Rac1 signaling pathway mediates contraction-regulated glucose uptake in skeletal muscle cells [0.03%]
AMPK/Axin1-Rac1信号通路介导骨骼肌细胞收缩依赖性葡萄糖摄取
Yingying Yue,Chang Zhang,Xuejiao Zhang et al.
Yingying Yue et al.
Contraction stimulates skeletal muscle glucose uptake predominantly through activation of AMP-activated protein kinase (AMPK) and Rac1. However, the molecular details of how contraction activates these signaling proteins are not clear. Rece...
Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet [0.03%]
PGC-1α介导了小鼠西式饮食诱导的肝脏脂肪变性过程中肝细胞CIDE族成员FSP27β性别差异表达的作用及意义研究
Luis V Herrera-Marcos,Sara Sancho-Knapik,Clara Gabás-Rivera et al.
Luis V Herrera-Marcos et al.
Hepatic fat-specific protein 27 [cell death-inducing DNA fragmentation effector protein C (Cidec)/Fsp27] mRNA levels have been associated with hepatic lipid droplet extent under certain circumstances. To address its hepatic expression under...
Acute interaction between human epicardial adipose tissue and human atrial myocardium induces arrhythmic susceptibility [0.03%]
人的心外膜脂肪组织与心房肌组织之间的急性相互作用会引发心律失常的易感性
Aram A Babakr,Ingrid C Fomison-Nurse,Isabelle van Hout et al.
Aram A Babakr et al.
Epicardial adipose tissue (EAT) deposition has a strong clinical association with atrial arrhythmias; however, whether a direct functional interaction exists between EAT and the myocardium to induce atrial arrhythmias is unknown. Therefore,...
Capillary blood tests may overestimate ketosis: triangulation between three different measures of β-hydroxybutyrate [0.03%]
毛细血管血液检测可能高估酮症：三种不同测量方法测定的β-羟基丁酸之间的三角关系
Jakob Norgren,Shireen Sindi,Anna Sandebring-Matton et al.
Jakob Norgren et al.
The ketone body β-hydroxybutyrate (BHB), assessed by a point-of-care meter in venous whole blood (BHBv), was used as the main outcome in a study on nutritional ketosis in healthy older adults. Two other BHB measures were also used in the s...
Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism [0.03%]
阿米替林通过调节鞘脂代谢抑制高脂肪饮食和LPS诱导的非酒精性steatohepatitis和动脉粥样硬化
Zhongyang Lu,Yanchun Li,Wing-Kin Syn et al.
Zhongyang Lu et al.
We reported previously that increased acid sphingomyelinase (ASMase)-catalyzed hydrolysis of sphingomyelin, which leads to increases in ceramide and sphingosine 1 phosphate (S1P), played a key role in the synergistic upregulation of proinfl...
miR-130b is a potent stimulator of hepatic very-low-density lipoprotein assembly and secretion via marked induction of microsomal triglyceride transfer protein [0.03%]
microRNA-miR-130b通过强烈诱导微粒体甘油三酯转移蛋白刺激肝细胞极低密度脂蛋白的组装和分泌
Jing Zhang,Ferdous Rastgar Jazii,Mahdi Montazer Haghighi et al.
Jing Zhang et al.
miR-130b is a microRNA whose expression is particularly elevated within adipose tissue and in the circulation in diabetic states. Hepatic miR-130b expression has been linked to hepatocellular carcinoma and changes in lipid metabolism. Here,...
Interaction between accumulated 21-deoxysteroids and mineralocorticoid signaling in 21-hydroxylase deficiency [0.03%]
21-羟化酶缺乏症患者中累积的21脱氧甾体与盐皮质激素信号的相互作用
Simon Travers,Claire Bouvattier,Jérôme Fagart et al.
Simon Travers et al.
21-Hydroxylase deficiency (21OHD) is a rare genetic disorder in which salt-wasting syndrome occurs in 75% of cases, due to inability to synthesize cortisol and aldosterone. Recent mass spectrometry progress allowed identification of 21-deox...
ELABELA measurements by commercial ELISA kits require sample extraction [0.03%]
商业型ELASA试剂盒需要通过样品提取来进行ELABELA测量
Danai Georgiadou,Souad Boussata,Marie van Dijk
Danai Georgiadou
Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor [0.03%]
溴隐亭能改善葡萄糖耐量独立于昼夜节律、泌乳素或黑皮质素-4受体的作用
Sarah N Framnes-DeBoer,Ellen Bakke,Suma Yalamanchili et al.
Sarah N Framnes-DeBoer et al.
Bromocriptine, a dopamine D2 receptor agonist originally used for the treatment of hyperprolactinemia, is largely successful in reducing hyperglycemia and improving glucose tolerance in type 2 diabetics. However, the mechanism behind bromoc...