Ketone monoester ingestion improves endothelial function during hyperglycemia in females with polycystic ovary syndrome [0.03%]
酮单酯摄入改善多囊卵巢综合征女性高血糖时的内皮功能
Danielle E Berbrier,Will Huckins,Shannon I Delage et al.
Danielle E Berbrier et al.
Postprandial hyperglycemia transiently impairs endothelial function. Polycystic ovary syndrome (PCOS) is associated with endothelial dysfunction and impaired glucose tolerance - both risk factors for cardiometabolic diseases - but the effec...
Synergistic Potential of TREM2 Agonists and Exercise Training in Alzheimer's Disease [0.03%]
激活TREM2和锻炼训练在阿尔茨海默病中的协同潜力
Jinmin Zhang,Barbara St Pierre Schneider,Elias Muguerza et al.
Jinmin Zhang et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-enriched receptor that regulates phagocytosis, lipid metabolism, and inflammation resolution in the brain. Loss or mutation of TREM2, including the R47H variant, impair...
Testosterone deficiency synergistically exacerbates fructose-induced hepatic steatosis through gut microbiota and pyruvate in mice [0.03%]
睾酮缺乏通过肠道微生物群和丙酮酸加剧果糖诱导的小鼠肝脂肪变性
Hiroki Takahashi,Naoki Harada,Yohei Hayamizu et al.
Hiroki Takahashi et al.
Hepatic steatosis is the initial stage of metabolic dysfunction-associated steatotic liver disease (MASLD) and is highly prevalent among middle-aged men. Low testosterone levels and dietary fructose intake are independent risk factors for M...
GLOBAL LOSS OF SELENOCYSTEINE LYASE IN MICE DRIVES LIPID ACCUMULATION IN BROWN ADIPOCYTES [0.03%]
硒代半胱氨酸裂解酶在小鼠中的整体缺失导致棕色脂肪细胞中脂质积累
Briana K Shimada,Ashley N Ogawa-Wong,Antonio G Soares et al.
Briana K Shimada et al.
The enzyme selenocysteine (Sec) lyase (SCLY) decomposes Sec releasing selenide for the synthesis of selenoproteins, which contain Sec in their primary structure and participate in strong redox reactions, maintaining redox balance. We previo...
Nr4a1 β-cell specific deletion impairs glucose tolerance in female mice [0.03%]
Nr4a1 β-细胞特异性删除可损害雌性小鼠的耐糖量
Jacob A Herring,Adam G Wynn,Talon J Aitken et al.
Jacob A Herring et al.
The Nr4a family of transcription factors control expression of genes essential for fuel metabolism and cellular proliferation. The loss of Nr4a1 in the 832/13 INS-1 β-cell line diminishes mitochondrial respiration, decreases ATP production...
Brittney A Covington,Zihan Tang,Lisette A Maddison et al.
Brittney A Covington et al.
Type 2 diabetes (T2D) involves progressive loss of functional β-cell mass. In a zebrafish insulin-resistant model (zMIR), overnutrition triggers islet inflammation and nocturnal β-cell death. The cell death is prevented by the cyclophilin...
RYGB Induces Vagal Sensory Neuropathy Characterized by Altered GLP1R Expression and Enhanced Exendin-4 Responsiveness in Male Mice [0.03%]
Roux-en-Y胃旁路诱导的迷走神经感觉神经病变及其特征性的GLP1R表达改变和增强的Exendin-4反应性：小鼠模型中的研究
Warda Merchant,Arely Salazar Tinajero,Adan Khan et al.
Warda Merchant et al.
The effects of Roux-en-Y gastric bypass (RYGB) on the gut-brain axis remain poorly understood. This study specifically explores phenotypic changes in vagal afferent neurons in male obese C57BL/6J mice following RYGB. Our results show that R...
GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice [0.03%]
远端肠道的GLP-1对于体重和葡萄糖调节是可有可无的，但可以减慢雌性小鼠的小肠转运速度
Thomas Uwe Greiner,Randy J Seeley,Fredrik Bäckhed
Thomas Uwe Greiner
Enteroendocrine cells (EECs) are specialized cells located throughout the gastrointestinal (GI) tract where they have an essential role in regulating various physiological processes related to digestion, metabolism, and gut physiology. EECs...
Xi Hu,Donghua Hu,Kun Chen et al.
Xi Hu et al.
UCP1, a mitochondrial protein traditionally regarded as exclusive to thermogenic adipocytes, and Ucp1-promoter-driven Cre is widely used in gene manipulation in thermogenic adipocytes. However, new evidence suggests that Ucp1-promoter-drive...
Intranasal insulin affects brain, but not peripheral tissue, glucose uptake in lean, healthy men - a positron emission tomography study [0.03%]
鼻内给药的胰岛素影响健康男性大脑而非周边组织的葡萄糖摄取-正电子放射断层扫描研究
Aino Latva-Rasku,Sanna Laurila,Tomi Karjalainen et al.
Aino Latva-Rasku et al.
The brain has been suggested to regulate glucose metabolism in response to insulin in various tissues. As many of these findings have not been studied in humans, we aimed to assess the effects of intranasal insulin (INI) on brain and periph...