Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and secretin stimulation of PAK4 and activation of Na+,K+-ATPase in pancreatic acinar cells [0.03%]
环磷酸腺苷依赖的蛋白激酶A和EPAC介导VP和分泌素刺激PAK4并在胰腺外分泌细胞中活化钠钾ATP酶
Irene Ramos-Alvarez,Lingaku Lee,R T Jensen
Irene Ramos-Alvarez
Rat pancreatic acinar cells possess only the p21-activated kinase (PAKs), PAK4 of the group II PAK, and it is activated by gastrointestinal hormones/neurotransmitters stimulating PLC and by a number of growth factors. However, little is kno...
Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations [0.03%]
IL-11过表达通过与遗传小鼠的gp130-JAK-STAT驱动突变隔离开来促进前癌胃上皮增生
Jon N Buzzelli,Louise O&#x;Connor,Michelle Scurr et al.
Jon N Buzzelli et al.
Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gastric pathology. Additionally, IL-11 is required for tumor development in STAT3-dependent murine models of gast...
Louis R Parham,Patrick A Williams,Priya Chatterji et al.
Louis R Parham et al.
Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different subtypes of epithelial cells, each with unique functional roles in responding to the ever-changing environment. T...
Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity [0.03%]
甘油三酯和脂肪酸对男性能量摄入、胃肠道转运及肠激素释放的影响（肥胖与非肥胖）
Carsten Dirksen,Jesper Graff,Stefan Fuglsang et al.
Carsten Dirksen et al.
Dietary fat, and particularly fatty acids (FAs) from hydrolyzed triglycerides (TGs), reduces appetite, whereas paradoxically, a high-fat diet leads to excess calorie intake. We therefore hypothesized that the appetite-regulating effects of ...
Factors influencing longitudinal changes of circulating liver enzyme concentrations in subjects randomized to placebo in four clinical trials [0.03%]
四项临床试验中接受安慰剂治疗的患者循环肝酶浓度纵向变化的影响因素分析
Derek J Nunez,Myriam Alexander,Laura Yerges-Armstrong et al.
Derek J Nunez et al.
Liver enzyme concentrations are measured as safety end points in clinical trials to detect drug-related hepatotoxicity, but little is known about the epidemiology of these biomarkers in subjects without hepatic dysfunction who are enrolled ...
Randomized Controlled Trial
American journal of physiology. Gastrointestinal and liver physiology. 2019 Mar 1;316(3):G372-G386. DOI:10.1152/ajpgi.00051.2018 2019
Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome [0.03%]
长期服用地洛他定导致肠系膜淋巴管功能障碍及肥胖/代谢综合征的发生发展
Olga Y Gasheva,Irina Tsoy Nizamutdinova,Laura Hargrove et al.
Olga Y Gasheva et al.
This study aimed to establish mechanistic links between the prolonged intake of desloratadine, a common H1 receptor blocker (i.e., antihistamine), and development of obesity and metabolic syndrome. Male Sprague-Dawley rats were treated for ...
Distinct roles of histamine H1- and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis [0.03%]
组胺H1和H2受体信号途径在炎症相关结肠肿瘤发生中的不同作用
Zhongcheng Shi,Robert S Fultz,Melinda A Engevik et al.
Zhongcheng Shi et al.
Inflammatory bowel disease (IBD) is a well-known risk factor for the development of colorectal cancer. Prior studies have demonstrated that microbial histamine can ameliorate intestinal inflammation in mice. We tested the hypothesis whether...
A novel role for programmed cell death receptor ligand 2 in sepsis-induced hepatic dysfunction [0.03%]
程序性死亡配体2在脓毒症诱导的肝功能障碍中的新作用
Anne-Lise Rossi,Marilyn Le,Chun-Shiang Chung et al.
Anne-Lise Rossi et al.
The liver is an organ that, when dysfunctional in a septic patient, is strongly associated with morbidity and mortality. Understanding the pathophysiology of liver failure during sepsis may lead to improved diagnostics and potential therape...
Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: new concept of absorption in jejunum [0.03%]
饮水通过增加肠系膜淋巴流量促进大鼠回肠营养物质转运的新概念：以蛋白质、脂肪和细胞因子为代表
Sachiho Nagashio,Kumiko Ajima,Daisuke Maejima et al.
Sachiho Nagashio et al.
The traditional Japanese health care custom recommends that a suitable volume of water is consumed. However, physiological and immunological mechanisms in support of this practice are unknown. Therefore, we conducted rat and rabbit in vivo ...