Targeted metabolomics analysis of maternal-placental-fetal metabolism in pregnant swine reveals links in fetal bile acid homeostasis and sulfation capacity [0.03%]
母体-胎盘-胎儿代谢组学分析揭示了胎儿胆汁酸稳态和硫酸化能力之间的联系
Peng Wang,Heju Zhong,Yumo Song et al.
Peng Wang et al.
Cholestasis of pregnancy endangers fetal and neonatal survival, yet systematic knowledge of the cause and effect of disrupted bile acid (BA) homeostasis in pregnancy is limited. Here we show that gestation stage-associated BA dysregulation ...
Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2/STAT pathway [0.03%]
肾素血管紧张素系统通过JAK2/STAT信号通路诱导TH17活化从而促进结肠炎症
Lei He,Jie Du,Yinyin Chen et al.
Lei He et al.
Previous studies suggest that the renin-angiotensin system (RAS) is a pathogenic factor for colitis. The goal of this study was to elucidate the molecular mechanism whereby angiotensin II (ANG II) promotes colonic inflammation. We found tha...
Xenin-25 induces anion secretion by activating noncholinergic secretomotor neurons in the rat ileum [0.03%]
Xenin-25通过激活回肠非胆碱能分泌神经元诱导阴离子分泌
Atsukazu Kuwahara,Yuko Kuwahara,Ikuo Kato et al.
Atsukazu Kuwahara et al.
Xenin-25 is a neurotensin-like peptide that is secreted by enteroendocrine cells in the small intestine. Xenin-8 is reported to augment duodenal anion secretion by activating afferent neural pathways. The intrinsic neuronal circuits mediati...
Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model [0.03%]
绿脓杆菌所致猪感染性休克模型中的空肠蛋白质合成与分解代谢的影响研究
Gabriëlla A M Ten Have,Mariëlle P K J Engelen,Robert R Wolfe et al.
Gabriëlla A M Ten Have et al.
Maintenance of gut integrity has long been recognized as crucial for survival in sepsis, but alterations in protein metabolism have not previously been documented. Therefore, in the present study, we measured in a Pseudomonas aeruginosa-ind...
Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice [0.03%]
小鼠细胞内胰蛋白酶活化加剧急性及慢性胰腺炎病情
Xianbao Zhan,Jianhua Wan,Guowei Zhang et al.
Xianbao Zhan et al.
Intra-acinar trypsinogen activation occurs in the earliest stages of pancreatitis and is believed to play important roles in pancreatitis pathogenesis. However, the exact role of intra-acinar trypsin activity in pancreatitis remains elusive...
microRNA-33a prevents epithelial-mesenchymal transition, invasion, and metastasis of gastric cancer cells through the Snail/Slug pathway [0.03%]
微小核糖核酸-33a通过Snail/Slug途径阻止胃癌细胞的上皮间质转化、侵袭和转移
Di-Di Chen,Jiang-Ting Cheng,Arvine Chandoo et al.
Di-Di Chen et al.
Invasion and metastasis are responsible for the majority of deaths in gastric cancer (GC). microRNA-33a (miR-33a) might function as a tumor suppressor in multiple cancers. Here, we describe the regulation and function of miR-33a in GC and m...
Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice [0.03%]
肠道蛋白酶抑制增加FGF21并改善肥胖小鼠代谢状况
Kamal Albarazanji,Matthew Jennis,Cassandre R Cavanaugh et al.
Kamal Albarazanji et al.
Trypsin is the major serine protease responsible for intestinal protein digestion. An inhibitor, camostat (CS), reduced weight gain, hyperglycemia, and dyslipidemia in obese rats; however, the mechanisms for these are largely unknown. We re...
TCF21 inhibits tumor-associated angiogenesis and suppresses the growth of cholangiocarcinoma by targeting PI3K/Akt and ERK signaling [0.03%]
TCF21通过靶向PI3K/Akt和ERK信号抑制肿瘤相关血管生成及肝内胆管癌生长
Hua-Xin Duan,Bo-Wen Li,Xin Zhuang et al.
Hua-Xin Duan et al.
Tumor-associated angiogenesis plays a critical role in the pathogenesis of cholangiocarcinoma (CCA). In this study, we examined the biological effects and molecular mechanisms of transcription factor 21 (TCF21) on CCA-associated angiogenesi...
Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model [0.03%]
TGR5激动剂对GLP-2分泌及促进短肠仔猪模型肠道适应的作用差异性研究
Sen Lin,Barbara Stoll,Jason Robinson et al.
Sen Lin et al.
Enteroendocrine L cells and glucagon-like peptide 2 (GLP-2) secretion are activated in the intestinal adaptation process following bowel resection in patients with short bowel syndrome. We hypothesized that enteral activation of Takeda G pr...
FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection [0.03%]
FXR激动剂GW4064改善小肠切除大鼠的肝肠病理改变及胆汁酸代谢
Yi Cao,Yongtao Xiao,KeJun Zhou et al.
Yi Cao et al.
Mortality associated with liver disease has been observed in patients with short bowel syndrome (SBS); however, its mechanism remains unclear, but bile acid (BA) dysmetabolism has been proposed as a possible cause. The farnesoid X receptor ...