Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p [0.03%]
长链非编码RNA PVT1通过上调microRNA-214-3p抑制结直肠癌的细胞增殖和侵袭
An-Quan Shang,Wei-Wei Wang,Yi-Bao Yang et al.
An-Quan Shang et al.
Long noncoding RNAs (lncRNAs) have been reported to be involved in the occurrence and tumorigenesis of numerous malignant cancers. Microarray expression profiles were used to screen colorectal cancer (CRC)-related differentially expressed g...
Role for diet in normal gut barrier function: developing guidance within the framework of food-labeling regulations [0.03%]
饮食在正常肠道屏障功能中的作用：在食品标签监管框架内制定指导原则
Michael Camilleri,Barbara J Lyle,Karen L Madsen et al.
Michael Camilleri et al.
A reduction in intestinal barrier function is currently believed to play an important role in pathogenesis of many diseases, as it facilitates passage of injurious factors such as lipopolysaccharide, peptidoglycan, whole bacteria, and other...
Gut and immune effects of bioactive milk factors in preterm pigs exposed to prenatal inflammation [0.03%]
生物活性牛奶因子对宫内炎症早产猪肠道和免疫的影响
Shuqiang Ren,Yan Hui,Sandra Goericke-Pesch et al.
Shuqiang Ren et al.
Prenatal inflammation may predispose to preterm birth and postnatal inflammatory disorders such as necrotizing enterocolitis (NEC). Bioactive milk ingredients may help to support gut maturation in such neonates, but mother's milk is often i...
Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon [0.03%]
氯筒箭毒碱和GRK2/3抑制剂可阻断回肠肌间神经元中δ型阿片受体的内陷并抑制小鼠结肠的神经肌肉传递作用
Jesse J DiCello,Pradeep Rajasekhar,Emily M Eriksson et al.
Jesse J DiCello et al.
Endocytosis is a major mechanism through which cellular signaling by G protein-coupled receptors (GPCRs) is terminated. However, recent studies demonstrate that GPCRs are internalized in an active state and continue to signal from within en...
Xiaomei Guo,Bhavesh Patel,Ling Han et al.
Xiaomei Guo et al.
The pathophysiology of colonic diverticulosis has not been completely understood. The development of appropriate animal models is essential to study diverticular disease. To date, no large animal models are available for this disease condit...
AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species [0.03%]
ROS抑制电解质转运和NKCC1活性的机制研究 AMPK的介导作用
Stephanie J King,Michael Bunz,Alfred Chappell et al.
Stephanie J King et al.
Reactive oxygen species such as H2O2 are believed to play a prominent role in the injury and loss of transport function that affect the intestinal epithelium in inflammatory conditions such as inflammatory bowel diseases. Defects in intesti...
Hypoxia-inducible factor hydroxylase inhibition enhances the protective effects of cyclosporine in colitis [0.03%]
缺氧诱导因子羟化酶抑制增强环孢素在结肠炎中的保护作用
Doug N Halligan,Mohammed N Khan,Eric Brown et al.
Doug N Halligan et al.
Inflammatory bowel disease (IBD) is characterized by epithelial barrier dysfunction with resultant inflammation as the mucosal immune system becomes exposed to luminal antigens. The hydroxylase inhibitor dimethyloxalylglycine (DMOG) reduces...
Perinatal high-fat diet alters development of GABAA receptor subunits in dorsal motor nucleus of vagus [0.03%]
孕期高脂饮食会改变迷走神经背核中GABA受体亚单位的发育
Courtney Clyburn,Caitlin A Howe,Amy C Arnold et al.
Courtney Clyburn et al.
Perinatal high-fat diet (pHFD) exposure increases the inhibition of dorsal motor nucleus of the vagus (DMV) neurons, potentially contributing to the dysregulation of gastric functions. The aim of this study was to test the hypothesis that p...
Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism [0.03%]
帕金森病大鼠模型脑干多巴胺能系统胃张力及运动反应的改变
Cecilia Bove,Laura Anselmi,R Alberto Travagli
Cecilia Bove
The majority of patients with Parkinson's disease (PD) experience gastrointestinal dysfunction. Recently, we described a nigro-vagal pathway that uses dopaminergic (DA) inputs to the dorsal motor nucleus of the vagus (DMV) and A2 area neuro...
LINC01018 confers a novel tumor suppressor role in hepatocellular carcinoma through sponging microRNA-182-5p [0.03%]
长链非编码RNA LINC01018通过海绵吸附microRNA-182-5p在肝细胞癌中发挥新型的抑癌作用
Shuai Wang,Mingfang Xu,Zhengang Sun et al.
Shuai Wang et al.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Emerging evidence has demonstrated that some long noncoding RNAs (lncRNAs) are involved in the development and progression of HCC. Herein, the current s...