Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice [0.03%]
肠道TGR5激动剂改善西方饮食喂养小鼠的肝脂肪变性和胰岛素抵抗
Patricia D Finn,David Rodriguez,Jill Kohler et al.
Patricia D Finn et al.
Takeda G protein-coupled receptor 5 (TGR5) agonists induce systemic release of glucagon-like peptides (GLPs) from intestinal L cells, a potentially therapeutic action against metabolic diseases such as nonalcoholic steatohepatitis (NASH), n...
Åke Nilsson,Rui-Dong Duan
Åke Nilsson
The digestion of choline phospholipids is important for choline homeostasis, lipid signaling, postprandial lipid and energy metabolism, and interaction with intestinal bacteria. The digestion is mediated by the combined action of pancreatic...
Ghrelin acylation by ghrelin- O-acyltransferase can occur in healthy part of oncological liver in humans [0.03%]
人癌肝组织中健康部分可以发生胃泌素肽的酰化作用
Natacha Germain,Joyceline Cuenco,Yiin Ling et al.
Natacha Germain et al.
Activation of ghrelin is controlled by the enzyme ghrelin- O-acyl transferase (GOAT). In humans, localization of this acylation is poorly understood. The aim of this study is to explore GOAT localization and activation in the human liver by...
Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium [0.03%]
主题系列介绍：肠道干细胞与美国国立糖尿病、消化病和肾脏病研究所的肠道干细胞联盟
Timothy C Wang,Martin G Martin,Calvin J Kuo et al.
Timothy C Wang et al.
Provocative testing in patients with jackhammer esophagus: evidence for altered neural control [0.03%]
杰克锤样失弛缓症患者的功能检查结果提示其存在神经调节异常
Aurelio Mauro,Farhan Quader,Salvatore Tolone et al.
Aurelio Mauro et al.
Jackhammer esophagus (JE) is a hypercontractile disorder, the pathogenesis of which is incompletely understood. Multiple rapid swallows (MRS) and rapid drink challenge (RDC) are complementary tests used during high-resolution manometry (HRM...
Liver repair and regeneration after ischemia-reperfusion injury is associated with prolonged fibrosis [0.03%]
缺血再灌注损伤后肝脏修复和再生与纤维化持续产生有关
Takanori Konishi,Rebecca M Schuster,Alex B Lentsch
Takanori Konishi
Liver recovery after hepatic ischemia-reperfusion (I/R) injury is characterized by clearance of dead tissue and its replacement with functional liver parenchyma. Previous reports have observed fibrosis after liver I/R. To determine whether ...
MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene [0.03%]
基质金属蛋白酶-9通过活化MLCK基因的p38激酶信号途径增加肠上皮通透性
Rana Al-Sadi,Moustafa Youssef,Manmeet Rawat et al.
Rana Al-Sadi et al.
Matrix metalloproteinase-9 (MMP-9) has been implicated as being an important pathogenic factor in inflammatory bowel disease (IBD). MMP-9 is markedly elevated in intestinal tissue of patients with IBD, and IBD patients have a defective inte...
Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila [0.03%]
动物界的肠道更新：比较小鼠和果蝇的干细胞活性
Rachel K Zwick,Benjamin Ohlstein,Ophir D Klein
Rachel K Zwick
The gastrointestinal (GI) tract renews frequently to sustain nutrient digestion and absorption in the face of consistent tissue stress. In many species, proliferative intestinal stem cells (ISCs) are responsible for the repair of the damage...
Pharyngoesophageal and cardiorespiratory interactions: potential implications for premature infants at risk of clinically significant cardiorespiratory events [0.03%]
咽食管和心肺相互作用：对有临床重大心肺事件风险的早产儿的意义
Kathryn A Hasenstab,Saira Nawaz,Ivan M Lang et al.
Kathryn A Hasenstab et al.
The aims of this study were to 1) examine pharyngoesophageal and cardiorespiratory responses to provoking pharyngeal stimuli, and 2) to determine potential contributory factors impacting heart rate (HR) changes to provide insight into cardi...
Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions [0.03%]
组胺通过T型电压门控钙通道诱导肠嗜铬肿瘤细胞系中的钙离子内流：不良食物反应的潜在治疗靶点
Beatrix Pfanzagl,Victor F Zevallos,Detlef Schuppan et al.
Beatrix Pfanzagl et al.
The P-STS human ileal neuroendocrine tumor cells, as a model for gut enterochromaffin cells, are strongly and synergistically activated by histamine plus acetylcholine (ACh), presumably via histamine 4 receptors, and weakly activated by his...