Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis [0.03%]
慢性酒精暴露会改变循环中的胰岛素和胃促生长素水平：胃促生长素在肝脂肪变性中发挥的作用
Karuna Rasineni,Paul G Thomes,Jacy L Kubik et al.
Karuna Rasineni et al.
Fatty liver is the earliest response of the liver to excessive ethanol consumption. Central in the development of alcoholic steatosis is increased mobilization of nonesterified free fatty acids (NEFAs) to the liver from the adipose tissue. ...
Differential biomechanical properties of mouse distal colon and rectum innervated by the splanchnic and pelvic afferents [0.03%]
脾神经和盆腔神经支配的远端结肠和直肠的生物力学性质差异性研究
Saeed Siri,Franz Maier,Longtu Chen et al.
Saeed Siri et al.
Visceral pain is one of the principal complaints of patients with irritable bowel syndrome, and this pain is reliably evoked by mechanical distension and stretch of distal colon and rectum (colorectum). This study focuses on the biomechanic...
G protein-coupled receptor trafficking and signaling: new insights into the enteric nervous system [0.03%]
G蛋白偶联受体的转运和信号转导：肠神经系统的新见解
Simona E Carbone,Nicholas A Veldhuis,Arisbel B Gondin et al.
Simona E Carbone et al.
G protein-coupled receptors (GPCRs) are essential for the neurogenic control of gastrointestinal (GI) function and are important and emerging therapeutic targets in the gut. Detailed knowledge of both the distribution and functional express...
Topographical plots of esophageal distension and contraction: effects of posture on esophageal peristalsis and bolus transport [0.03%]
食管扩张和收缩的地形图：体位对食管蠕动和团块运输的影响
Ali Zifan,Hyun Joo Song,Young-Hoon Youn et al.
Ali Zifan et al.
Each swallow induces a wave of inhibition followed by contraction in the esophagus. Unlike contraction, which can easily be measured in humans using high-resolution manometry (HRM), inhibition is difficult to measure. Luminal distension is ...
Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals [0.03%]
不同程度的非酒精性脂肪肝病患者与健康正常体重个体肝脏转录组特征比较研究
Malte P Suppli,Kristoffer T G Rigbolt,Sanne S Veidal et al.
Malte P Suppli et al.
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of conditions ranging from simple steatosis (NAFL), over nonalcoholic steatohepatitis (NASH) with or without fibrosis, to cirrhosis with end-stage disease. The hepatic molecular...
Defective FXR-FGF15 signaling and bile acid homeostasis in cystic fibrosis mice can be restored by the laxative polyethylene glycol [0.03%]
囊性纤维病小鼠的FXR-FGF15信号传导和胆汁酸稳态异常可通过导泻剂聚乙二醇恢复
Anna Bertolini,Ivo P van de Peppel,Marcela Doktorova-Demmin et al.
Anna Bertolini et al.
The gastrointestinal phenotype of cystic fibrosis (CF) features intestinal bile acid (BA) malabsorption, impaired intestinal farnesoid X receptor (FXR) activation, and consequently reduced fibroblast growth factor 19 (FGF19, FGF15 in mice) ...
AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury [0.03%]
AKT激活剂SC79可保护肝细胞免于TNF-α介导的凋亡及改善d- GAL / LPS诱导的肝损伤
Zhen-Tang Jing,Wei Liu,Chao-Rong Xue et al.
Zhen-Tang Jing et al.
Tumor necrosis factor-α (TNF-α) is a highly pleiotropic cytokine executing biological functions as diverse as cell proliferation, metabolic activation, inflammatory responses, and cell death. TNF-α can induce multiple mechanisms to initi...
Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome [0.03%]
组胺介导的瞬时受体电位锚定1和瞬时受体电位香草酸4在ibs患者肠黏膜神经元中的信号转导增强现象研究
D Balemans,J Aguilera-Lizarraga,M V Florens et al.
D Balemans et al.
Previously, we showed histamine-mediated sensitization of transient receptor potential (TRP) vanilloid 1 (TRPV1) in patients with irritable bowel syndrome (IBS). Sensitization of TRP ankyrin 1 (TRPA1) and TRP vanilloid 4 (TRPV4) are also in...
Decreased electrogenic anionic secretory response in the porcine colon following in vivo challenge with Brachyspira spp. supports an altered mucin environment [0.03%]
暴露于Brachyspira菌株后猪结肠电中性阴离子分泌反应降低支持黏蛋白环境发生改变
Cole B Enns,John C S Harding,Matthew E Loewen
Cole B Enns
Brachyspira spp. cause diarrheal disease in multiple animal species by colonization of the colon, resulting in colitis, mucus induction, and disrupted ion transport. Unique to spirochete pathogenesis is the immense production of mucus, resu...
Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine [0.03%]
dietary胆固醇和载脂蛋白A-I在活体斑马鱼肠道内陷囊和溶酶体中的转运
Jessica P Otis,Meng-Chieh Shen,Blake A Caldwell et al.
Jessica P Otis et al.
Difficulty in imaging the vertebrate intestine in vivo has hindered our ability to model nutrient and protein trafficking from both the lumenal and basolateral aspects of enterocytes. Our goal was to use live confocal imaging to increase un...