Translational and transcriptional responses in human primary hepatocytes under hypoxia [0.03%]
人类原代肝细胞缺氧条件下的转录与翻译反应
Gaya K Hettiarachchi,Upendra K Katneni,Ryan C Hunt et al.
Gaya K Hettiarachchi et al.
The liver is the primary source of a large number of plasma proteins and plays a critical role in multiple biological processes. Inadequate oxygen supply characterizing various clinical settings such as liver transplantation exposes the liv...
Multitranscriptome analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology [0.03%]
多转录组分析揭示了与肝纤维化进展特异性相关的优先基因（独立于病因）
Wei Chen,Xiaoning Wu,Xuzhen Yan et al.
Wei Chen et al.
Elimination or suppression of causative factors can raise the possibility of liver fibrosis regression. However, different injurious stimuli will give fibrosis from somewhat different etiologies, which, in turn, may hamper the discovery of ...
Intrapancreatic fat deposition and visceral fat volume are associated with the presence of diabetes after acute pancreatitis [0.03%]
急性胰腺炎后院内新发糖尿病与腹腔内脂肪沉积及内脏脂肪体积增加有关
Ruma G Singh,Aya Cervantes,Jin Uk Kim et al.
Ruma G Singh et al.
Ectopic fat and abdominal adiposity phenotypes have never been studied holistically in individuals after acute pancreatitis (AP). The aim of the study was to investigate phenotypical differences in ectopic fat and abdominal fat between indi...
Portal milieu and the interplay of multiple antidiabetic effects after gastric bypass surgery [0.03%]
胃旁路术后“通道”微环境与多重降糖效应的交互作用
Atanu Pal,David B Rhoads,Ali Tavakkoli
Atanu Pal
Diabetes is a worldwide health problem. Roux-en-Y gastric bypass (RYGB) leads to rapid resolution of type 2 diabetes (T2D). Decreased hepatic insulin resistance is key, but underlying mechanisms are poorly understood. We hypothesized that c...
Wnt signaling inhibition by monensin results in a period of Hippo pathway activation during intestinal adaptation in zebrafish [0.03%]
环孢素通过抑制Wnt信号通路在斑马鱼肠适应过程中激活Hippo信号通路
Mubina A Isani,Kristin Gee,Kathy Schall et al.
Mubina A Isani et al.
Intestinal adaptation (IA) is a critical response to increase epithelial surface area after intestinal loss. Short bowel syndrome (SBS) may follow massive intestinal resection in human patients, particularly without adequate IA. We previous...
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis [0.03%]
肝肿瘤中的肝CYP1A2活性及术前体积-功能分析的意义
Tilo Wuensch,Niklas Heucke,Jonas Wizenty et al.
Tilo Wuensch et al.
Dynamic liver function assessment by the [13C]methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic cytochrome P-450 (CYP) 1A2 activity. One proven strategy for preoperative risk assessment in liver surgery in...
Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer [0.03%]
全反式维甲酸的抗肿瘤作用及其与吉西他滨的协同作用与胰腺癌中p21激活激酶的下调有关
Kai Wang,Graham S Baldwin,Mehrdad Nikfarjam et al.
Kai Wang et al.
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies worldwide. All-trans retinoic acid (ATRA) has been used as an antistromal agent in PDA, and its antitumor effect has also been reported in various kinds of cancer...
TO901317 inhibits the development of hepatocellular carcinoma by LXRα/Glut1 decreasing glycometabolism [0.03%]
TO901317通过LXRα/Glut1减少糖代谢来抑制肝癌的发展
Ting Xiong,Zihan Li,Xuelong Huang et al.
Ting Xiong et al.
This study was conducted to observe the effect and possible mechanism of TO901317 in vivo and in vitro to provide a new basis for the targeted therapy of hepatocellular carcinoma (HCC). The expressions of liver X receptor (LXR)-α, glucose ...
Interplay of spinal and vagal pathways on esophageal acid-related anterior cingulate cortex functional networks in rats [0.03%]
脊髓和迷走神经通路在大鼠食管酸相关前扣带回功能网络中的交互作用
Patrick Sanvanson,Zhixin Li,Ling Mei et al.
Patrick Sanvanson et al.
Esophageal acid sensory signals are transmitted by both vagal and spinal pathways to the cerebral cortex. The influence and interplay of these pathways on esophageal acid-related functional connectivity has been elusive. Our aim was to eval...
Intestinal iNKT cells migrate to liver and contribute to hepatocyte apoptosis during alcoholic liver disease [0.03%]
肠驻留的iNKT细胞迁移到肝脏并参与酒精性肝病中的肝细胞凋亡
Kuei-Chuan Lee,Peng Chen,Igor Maricic et al.
Kuei-Chuan Lee et al.
We investigated the migration of intestinal immune cells to the liver and their contribution to alcoholic liver disease. In mice fed ethanol, we found that an increased number of invariant natural killer T (iNKT) cells, which respond to the...