Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis [0.03%]
酒精和代谢损伤联合四氯化碳诱导的肝纤维化模型小鼠的研究
Maximilian Joseph Brol,Felicitas Rösch,Robert Schierwagen et al.
Maximilian Joseph Brol et al.
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or alcoholic (ALD) fatty liver disease, respectively. In particular, presence of fibrosis in NAFLD and ALD requires treatment, but development of drugs is hampered by the...
Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord [0.03%]
胸腰段和腰骶段脊髓的结肠传入输入和背角神经元激活有所不同
Andrea M Harrington,Sonia Garcia Caraballo,Jessica E Maddern et al.
Andrea M Harrington et al.
The distal colon is innervated by the splanchnic and pelvic nerves, which relay into the thoracolumbar and lumbosacral spinal cord, respectively. Although the peripheral properties of the colonic afferent nerves within these pathways are we...
NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis [0.03%]
NTPDase1和-N2在小鼠结肠中的表达细胞区室不同，并且在DSS结肠炎后对结肠生理和功能的影响不同
Vladimir Grubišić,Alberto L Perez-Medina,David E Fried et al.
Vladimir Grubišić et al.
ATP is both an important mediator of physiological gut functions such as motility and epithelial function, and a key danger signal that mediates cell death and tissue damage. The actions of extracellular ATP are regulated through the cataly...
Thomas Knöpfel,Nina Himmerkus,Dorothee Günzel et al.
Thomas Knöpfel et al.
Inorganic phosphate (Pi) is crucial for many biological functions, such as energy metabolism, signal transduction, and pH buffering. Efficient systems must exist to ensure sufficient supply for the body of Pi from diet. Previous experiments...
Slow-wave coupling across a gastroduodenal anastomosis as a mechanism for postsurgical gastric dysfunction: evidence for a "gastrointestinal aberrant pathway" [0.03%]
胃空肠吻合术后胃肠慢波耦联异常导致的胃功能障碍及“胃肠异病途径”学说证据
Tim H-H Wang,Timothy R Angeli,Grant Beban et al.
Tim H-H Wang et al.
Postsurgical gastric dysfunction is common, but the mechanisms are varied and poorly understood. The pylorus normally acts as an electrical barrier isolating gastric and intestinal slow waves. In this report, we present an aberrant electric...
Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes [0.03%]
乙醛通过抑制HBV-MHCI复合物的产生从而促进慢性乙肝病毒感染
Murali Ganesan,Vjaceslav M Krutik,Edward Makarov et al.
Murali Ganesan et al.
Hepatitis B virus (HBV) infection and alcoholism are major public health problems worldwide, contributing to the development of end-stage liver disease. Alcohol intake affects HBV infection pathogenesis and treatment outcomes. HBV-specific ...
Protective effects of maresin 1 against inflammation in experimentally induced acute pancreatitis and related lung injury [0.03%]
maresin 1对实验性急性胰腺炎及其相关肺损伤的抗炎保护作用
Fahad Munir,Muhammad Babar Jamshed,Numan Shahid et al.
Fahad Munir et al.
Severe acute pancreatitis (SAP) is an inflammatory disorder that progresses with local and systemic difficulties accompanied by a relatively high mortality rate. In recent years, maresin 1 (MaR1) has been shown to be a macrophage mediator w...
Prenatal inflammation impairs intestinal microvascular development through a TNF-dependent mechanism and predisposes newborn mice to necrotizing enterocolitis [0.03%]
宫内炎症通过依赖TNF的机制损害肠微血管发育并使小鼠易患坏死性小肠结肠炎
Xiaocai Yan,Elizabeth Managlia,Xiao-Di Tan et al.
Xiaocai Yan et al.
Prenatal inflammation is a risk factor for necrotizing enterocolitis (NEC), and it increases intestinal injury in a rat NEC model. We previously showed that maldevelopment of the intestinal microvasculature and lack of vascular endothelial ...
Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p [0.03%]
长链非编码RNA PVT1通过上调microRNA-214-3p抑制结直肠癌的细胞增殖和侵袭
An-Quan Shang,Wei-Wei Wang,Yi-Bao Yang et al.
An-Quan Shang et al.
Long noncoding RNAs (lncRNAs) have been reported to be involved in the occurrence and tumorigenesis of numerous malignant cancers. Microarray expression profiles were used to screen colorectal cancer (CRC)-related differentially expressed g...
Role for diet in normal gut barrier function: developing guidance within the framework of food-labeling regulations [0.03%]
饮食在正常肠道屏障功能中的作用：在食品标签监管框架内制定指导原则
Michael Camilleri,Barbara J Lyle,Karen L Madsen et al.
Michael Camilleri et al.
A reduction in intestinal barrier function is currently believed to play an important role in pathogenesis of many diseases, as it facilitates passage of injurious factors such as lipopolysaccharide, peptidoglycan, whole bacteria, and other...