Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity [0.03%]
二甲双胍通过改变十二指肠菌群减少饮食诱导肥胖小鼠的胰腺导管腺癌发生率
Tien S Dong,Hui-Hua Chang,Meg Hauer et al.
Tien S Dong et al.
Pancreatic ductal adenocarcinoma (PDAC)'s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have shown that metformin can prevent the increased incidence of PDAC in a KrasG12D mouse ...
MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells [0.03%]
substance P诱导的外泌体中的mir-21促进人类结肠上皮细胞增殖和迁移
Kyriaki Bakirtzi,Ivy Ka Man Law,Kai Fang et al.
Kyriaki Bakirtzi et al.
Exosomes are cellular vesicles involved in intercellular communication via their specialized molecular cargo, such as miRNAs. Substance P (SP), a neuropeptide/hormone, and its high-affinity receptor, NK-1R, are highly expressed during colon...
The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation [0.03%]
长非编码RNA IFNG-AS1调控IBD中T细胞活化后的炎症与抗炎细胞因子平衡
Carl Robert Rankin,Ling Shao,Julie Elliott et al.
Carl Robert Rankin et al.
The inflammatory bowel diseases (IBD) are a complex set of chronic gastrointestinal inflammatory conditions arising from the interplay of genetic and environmental factors. This study focuses on noncoding RNA transcripts as potential mediat...
Harmeet Malhi
Harmeet Malhi
Extracellular vesicles (EVs) are membrane-defined nanoparticles released by most cell types. The EVs released by cells may differ quantitatively and qualitatively from physiological states to disease states. There are several unique propert...
NSAID-induced injury of gastric epithelial cells is reversible: roles of mitochondria, AMP kinase, NGF, and PGE2 [0.03%]
非甾体抗炎药所致胃上皮细胞损伤是可逆的：线粒体、AMP活化蛋白激酶、NGF和PGE2的作用
Amrita Ahluwalia,Neil Hoa,Michael K Jones et al.
Amrita Ahluwalia et al.
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DFN) and indomethacin (INDO) are extensively used worldwide. Their main side effects are injury of the gastrointestinal tract, including erosions, ulcers, and bleeding. Since...
Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases [0.03%]
基于MC38实验性肝转移小鼠的基质组蛋白质组分析
Arseniy E Yuzhalin,Su Yin Lim,Alex N Gordon-Weeks et al.
Arseniy E Yuzhalin et al.
Dissemination of primary tumors to distant anatomical sites has a substantial negative impact on patient prognosis. The liver is a common site for metastases from colorectal cancer, and patients with hepatic metastases have generally much s...
OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids [0.03%]
OATP1B3-1B7是一种新的有机阴离子转运多肽，受FXR配体调节并运输胆汁酸
Vanessa Malagnino,Janine Hussner,Ali Issa et al.
Vanessa Malagnino et al.
Organic anion transporting polypeptide (OATP) 1B3-1B7 (LST-3TM12) is a member of the OATP1B [solute carrier organic anion transporter (SLCO) 1B] family. This transporter is not only functional but also expressed in the membrane of the smoot...
Nod2 deficiency functionally impairs adaptation to short bowel syndrome via alterations of the epithelial barrier function [0.03%]
Nod2缺陷通过上皮屏障功能的改变在功能上损害了对短肠综合征的适应能力
Peggy Berlin,Johannes Reiner,Maria Witte et al.
Peggy Berlin et al.
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene mutations are a risk factor for Crohn's disease and also associated with worse outcome in short bowel syndrome (SBS) patients independent of the underlying disease. ...
Ursodeoxycholic acid: a promising therapeutic target for inflammatory bowel diseases? [0.03%]
乌索熊去氧胆酸：炎症性肠病的潜在治疗靶点？
Stephen J Keely,Clifford J Steer,Natalia K Lajczak-McGinley
Stephen J Keely
The secondary bile acid ursodeoxycholic acid (UDCA) has long been known to have medicinal properties. As the therapeutically active component of bear bile, it has been used for centuries in traditional Chinese medicine to treat a range of c...
Possible application of melatonin treatment in human diseases of the biliary tract [0.03%]
褪黑素治疗人类胆道疾病的应用 возможен ли использовать мелатонин в лечении заболеваний желчных путей у человека？
Leonardo Baiocchi,Tianhao Zhou,Suthat Liangpunsakul et al.
Leonardo Baiocchi et al.
Melatonin was discovered in 1958 by Aaron Lerner. Its name comes from the ability of melatonin to change the shape of amphibian melanophores from stellate to roundish. Starting from the 1980s, the role of melatonin in the regulation of mamm...