Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis [0.03%]
高脂饮食和肠道芳香烃受体缺失对结肠致癌的影响
Erika L Garcia-Villatoro,Jennifer A A DeLuca,Evelyn S Callaway et al.
Erika L Garcia-Villatoro et al.
Consumption of a high-fat diet has been associated with an increased risk of developing colorectal cancer (CRC). However, the effects of the interaction between dietary fat content and the aryl hydrocarbon receptor (AhR) on colorectal carci...
Kent A Willis,Charles K Gomes,Prahlad Rao et al.
Kent A Willis et al.
Bile acid receptors regulate the metabolic and immune functions of circulating enterohepatic bile acids. This process is disrupted by administration of parenteral nutrition (PN), which may induce progressive hepatic injury for unclear reaso...
Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice [0.03%]
肠脂肪酸结合蛋白（IFABP）基因敲除小鼠体重增长降低的机制研究
Atreju I Lackey,Tina Chen,Yin X Zhou et al.
Atreju I Lackey et al.
Intestinal-fatty acid binding protein (IFABP; FABP2) is a 15-kDa intracellular protein abundantly present in the cytosol of the small intestinal (SI) enterocyte. High-fat (HF) feeding of IFABP-/- mice resulted in reduced weight gain and fat...
Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit [0.03%]
结肠传输缓慢的患者远端结肠传输与肠道微生物多样性和微生物发酵有关
Mattea Müller,Gerben D A Hermes,Emanuel E Canfora et al.
Mattea Müller et al.
Longer colonic transit time and hard stools are associated with increased gut microbiota diversity. Here, we investigate to what extent quantitative measures of (segmental) colonic transit time were related to gut microbiota composition, mi...
RYK, a receptor of noncanonical Wnt ligand Wnt5a, is positively correlated with gastric cancer tumorigenesis and potential of liver metastasis [0.03%]
RYK非经典的Wnt配体Wnt5a的受体，与胃癌发生及肝转移潜能呈正相关
Yongan Fu,Yilin Chen,Jinghua Huang et al.
Yongan Fu et al.
Gastric cancer (GC) is the most prevalent human cancer around the globe. In GC, Wnt signaling is deregulated, and receptor-like tyrosine kinase (RYK) coreceptors have been identified to interact with noncanonical Wnt ligand Wnt5a. We, there...
Dobutamine reverses the cardio-suppressive effects of terlipressin without improving renal function in cirrhosis and ascites: a randomized controlled trial [0.03%]
多巴胺逆转特立普利森在肝硬化和腹水中的心脏抑制作用而不改善肾功能：一项随机对照试验
Mads Israelsen,Emilie Kristine Dahl,Bjørn Stæhr Madsen et al.
Mads Israelsen et al.
Acute kidney injury and hepatorenal syndrome (HRS) are frequent complications in patients with cirrhosis and ascites. First-line treatment is terlipressin, which reverses HRS in ~40% of patients but also lowers cardiac output (CO). We aimed...
Randomized Controlled Trial
American journal of physiology. Gastrointestinal and liver physiology. 2020 Feb 1;318(2):G313-G321. DOI:10.1152/ajpgi.00328.2019 2020
A myogenic motor pattern in mice lacking myenteric interstitial cells of Cajal explained by a second coupled oscillator network [0.03%]
卡哈尔(myenteric)间质细胞缺乏小鼠的肌源性运动模式可由第二个耦合振荡器网络解释
Sean P Parsons,Jan D Huizinga
Sean P Parsons
The interstitial cells of Cajal associated with the myenteric plexus (ICC-MP) are a network of coupled oscillators in the small intestine that generate rhythmic electrical phase waves leading to corresponding waves of contraction, yet rhyth...
Mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis in cirrhotic rats [0.03%]
线粒体靶向抗氧化剂辅酶Q局部肝动脉给药可减轻肝硬化大鼠肝炎症及纤维化
Saadet Turkseven,Massimo Bolognesi,Alessandra Brocca et al.
Saadet Turkseven et al.
In liver cirrhosis, oxidative stress plays a major role in promoting liver inflammation and fibrosis. Mitochondria dysregulation is responsible for excessive reactive oxygen species production. Therefore, in an experimental model of cirrhos...
IFN-γ and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon [0.03%]
IFN-γ和IL-17A调节健康结肠和炎症结肠隐窝CXCL10的产生
Travis Walrath,Robert A Malizia,Xinjun Zhu et al.
Travis Walrath et al.
During intestinal inflammation, immature cells within the intestinal crypt are called upon to replenish lost epithelial cell populations, promote tissue regeneration, and restore barrier integrity. Inflammatory mediators including TH1/TH17-...
Diversity of neurogenic smooth muscle electrical rhythmicity in mouse proximal colon [0.03%]
小鼠近端结肠神经源性平滑肌电节律多样性的研究
Nick J Spencer,Lee Travis,Lukasz Wiklendt et al.
Nick J Spencer et al.
The mechanisms underlying electrical rhythmicity in smooth muscle of the proximal colon are incompletely understood. Our aim was to identify patterns of electrical rhythmicity in smooth muscle of the proximal region of isolated whole mouse ...