Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy [0.03%]
心房特异性过表达 Caveolin-3 在肝硬化心肌病中的保护作用
So Yeon Kim,Kang Ho Kim,Jan M Schilling et al.
So Yeon Kim et al.
Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critica...
Keap1 deletion accelerates mutant K-ras/ p53-driven cholangiocarcinoma [0.03%]
Keap1缺失加速突变K-ras/p53驱动的胆管癌发展
Tatsuhide Nabeshima,Shin Hamada,Keiko Taguchi et al.
Tatsuhide Nabeshima et al.
The activation of the Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) pathway contributes to cancer progression in addition to oxidative stress responses. Loss-of-function Keap1 mutations were reported to activate ...
Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome [0.03%]
蛋氨酸饮食补充增强电离辐射引起的胃肠综合症
Isabelle R Miousse,Laura E Ewing,Charles M Skinner et al.
Isabelle R Miousse et al.
Methionine is an essential amino acid needed for a variety of processes in living organisms. Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA methylation and decreased synthesis of glutathione. In th...
Takanori Konishi,Rebecca M Schuster,Holly S Goetzman et al.
Takanori Konishi et al.
Hepatic ischemia-reperfusion (I/R) is a major complication of liver resection, trauma, and liver transplantation; however, liver repair after I/R in diseased liver has not been studied. The present study sought to determine the manner in wh...
Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver [0.03%]
纳米配方SOD1通过调节脂肪组织和肝脏中的CYP2E1表达在一定程度上改善了非酒精性脂肪肝病和酒精相关性肝病的联合损伤
Thiyagarajan Gopal,Narendra Kumar,Curtis Perriotte-Olson et al.
Thiyagarajan Gopal et al.
Enhanced free fatty acid (FFA) flux from adipose tissue (AT) to liver plays an important role in the development of nonalcoholic steatohepatitis (NASH) and alcohol-associated liver disease (AALD). We determined the effectiveness of nanoform...
Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis [0.03%]
肌球蛋白调节因子和肌球蛋白相关转录因子A协同介导肌动蛋白细胞质骨架依赖性抑制肝纤维化的作用机制研究
Zengdun Shi,Mudan Ren,Don C Rockey
Zengdun Shi
Activation of hepatic stellate cells (HSCs), characterized by development of a robust actin cytoskeleton and expression of abundant extracellular matrix (ECM) proteins, such as type 1 collagen (COL.1), is a central cellular and molecular ev...
Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor-γ system in experimental rat Barrett's esophagus [0.03%]
表皮生长因子与环氧合酶-2产物及过氧化物酶体增殖激活受体-γ系统在实验性大鼠巴雷特食管中的相互作用
Jolanta Majka,Mateusz Wierdak,Aleksandra Szlachcic et al.
Jolanta Majka et al.
Mixed acidic-alkaline refluxate is a major pathogenic factor in chronic esophagitis progressing to Barrett's esophagus (BE). We hypothesized that epidermal growth factor (EGF) can interact with COX-2 and peroxisome proliferator-activated re...
Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis [0.03%]
反式脂肪和酒精对啮齿动物非酒精性 steatohepatitis 模型中动脉粥样genic饮食诱导的肝损伤的影响不同
Samuel J Daniels,Diana J Leeming,Sönke Detlefsen et al.
Samuel J Daniels et al.
Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are common causes of chronic liver disease. The overlap between ALD and NAFLD suggests the existence of metabolic steatohepatitis. Development of in vivo models that...
Investigating fibrosis and inflammation in an ex vivo NASH murine model [0.03%]
在体外的NASH小鼠模型中研究纤维化和炎症
Emilia Gore,Emilia Bigaeva,Anouk Oldenburger et al.
Emilia Gore et al.
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, characterized by excess fat accumulation (steatosis). Nonalcoholic steatohepatitis (NASH) develops in 15-20% of NAFLD patients and frequently progresses to liver fib...
Role of microRNA-210-3p in hepatitis B virus-related hepatocellular carcinoma [0.03%]
microRNA-210-3p在乙型肝炎病毒相关性肝癌中的作用研究进展
Asahiro Morishita,Koji Fujita,Hisakazu Iwama et al.
Asahiro Morishita et al.
Hepatitis B virus (HBV)-related hepatocarcinogenesis is not necessarily associated with the liver fibrotic stage and is occasionally seen at early fibrotic stages. MicroRNAs (miRNAs) are essentially 18- to 22-nucleotide-long endogenous nonc...