Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism [0.03%]
肠特异性删除金属转运蛋白Zip14(Slc39a14)导致锰性脑病相关的行为缺陷及大脑蓄积过度锰离子
Tolunay B Aydemir,Trista L Thorn,Courtney H Ruggiero et al.
Tolunay B Aydemir et al.
Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is dependent on effective Mn elimination. Specific metal transporters contr...
Intestinal epithelial regeneration: active versus reserve stem cells and plasticity mechanisms [0.03%]
肠上皮再生：主动与储备干细胞及转分化机制
Soham Karmakar,Lu Deng,Xi C He et al.
Soham Karmakar et al.
The gastrointestinal system is arguably one of the most complicated developmental systems in a multicellular organism, as it carries out at least four major functions: digestion of food, absorption of nutrients, excretion of hormones, and d...
Pregnancy facilitates maternal liver regeneration after partial hepatectomy [0.03%]
妊娠促进肝脏部分切除术后母体肝再生
Joonyong Lee,Veronica Garcia,Shashank Manohar Nambiar et al.
Joonyong Lee et al.
Liver resection induces robust liver regrowth or regeneration to compensate for the lost tissue mass. In a clinical setting, pregnant women may need liver resection without terminating pregnancy in some cases. However, how pregnancy affects...
Bile acid treatment and FXR agonism lower postprandial lipemia in mice [0.03%]
胆酸治疗和FXR激动作用可降低小鼠餐后高脂血症水平
Sarah Farr,Bogdan Stankovic,Simon Hoffman et al.
Sarah Farr et al.
Postprandial dyslipidemia is a common feature of insulin-resistant states and contributes to increased cardiovascular disease risk. Recently, bile acids have been recognized beyond their emulsification properties as important signaling mole...
Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH [0.03%]
新型猪儿童NASH模型中的FXR-FGF19信号失调和胆碱代谢与肠道菌群失调和增生有关
Gabriella V Hernandez,Victoria A Smith,Megan Melnyk et al.
Gabriella V Hernandez et al.
To investigate the role of bile acids (BAs) in the pathogenesis of diet-induced nonalcoholic steatohepatitis (NASH), we fed a "Western-style diet" [high fructose, high fat (HFF)] enriched with fructose, cholesterol, and saturated fat for 10...
Vitamin D signaling maintains intestinal innate immunity and gut microbiota: potential intervention for metabolic syndrome and NAFLD [0.03%]
维生素D信号传导维系肠内固有免疫和肠道菌群：代谢综合征和NAFLD的潜在干预手段
Yilan Zeng,Mei Luo,Liwei Pan et al.
Yilan Zeng et al.
A lack of sunlight exposure, residence in the northern latitudes, and dietary vitamin D insufficiency are coprevalent with metabolic syndrome (MetS), Type 2 diabetes (T2D), and nonalcoholic fatty liver diseases (NAFLD), implying a potential...
Group II p21-activated kinase, PAK4, is needed for activation of focal adhesion kinases, MAPK, GSK3, and β-catenin in rat pancreatic acinar cells [0.03%]
胰泌酶原激活小鼠胰腺外分泌细胞中PAK4对于斑点黏着蛋白激酶、MAPK、GSK3和β-连环素活化的作用
Irene Ramos-Álvarez,Lingaku Lee,Robert T Jensen
Irene Ramos-Álvarez
PAK4 is the only member of the Group II p21-activated kinases (PAKs) present in rat pancreatic acinar cells and is activated by gastrointestinal hormones/neurotransmitters stimulating PLC/cAMP and by various pancreatic growth factors. Howev...
In Barrett's epithelial cells, weakly acidic bile salt solutions cause oxidative DNA damage with response and repair mediated by p38 [0.03%]
巴雷特食管上皮细胞中弱酸性胆盐溶液导致氧化DNA损伤及p38介导的应答和修复反应
Xiaofang Huo,Kerry B Dunbar,Xi Zhang et al.
Xiaofang Huo et al.
The frequency of esophageal adenocarcinoma is rising despite widespread use of proton pump inhibitors (PPIs), which heal reflux esophagitis but do not prevent reflux of weakly acidic gastric juice and bile in Barrett's esophagus patients. W...
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy [0.03%]
胆汁酸受体FXR和TGR5在脂肪性肝病中的作用及治疗靶点效应研究进展
John Y L Chiang,Jessica M Ferrell
John Y L Chiang
Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for maintenance of whole body cholesterol homeostasis. Bile acids are physiological detergents that absorb, distribute, metabolize, and excrete nutrients,...
Sacral nerve stimulation increases gastric accommodation in rats: a spinal afferent and vagal efferent pathway [0.03%]
骶神经刺激可增加大鼠胃容积：一种脊髓传入和迷走传出途径
Feng Ye,Yi Liu,Shiying Li et al.
Feng Ye et al.
Impaired gastric accommodation (GA) has been frequently reported in various gastrointestinal diseases. No standard treatment strategy is available for treating impaired GA. We explored the possible effect of sacral nerve stimulation (SNS) o...