Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions [0.03%]
重症新生儿贫血通过破坏上皮粘附带增加肠道通透性
Krishnan MohanKumar,Kopperuncholan Namachivayam,Nithya Sivakumar et al.
Krishnan MohanKumar et al.
Anemia is a frequent diagnosis in critically ill infants, but the clinical implications of severe anemia in these patients remain unclear. In this study, we examined preweaned mice to investigate the effects of severe anemia during early in...
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels [0.03%]
衰老相关肝退化与体内细菌内毒素及脂多糖结合蛋白水平升高有关
Cheng Jun Jin,Anja Baumann,Annette Brandt et al.
Cheng Jun Jin et al.
Aging is a risk factor in the development of many diseases, including liver-related diseases. The two aims of the present study were 1) to determine how aging affects liver health in mice in the absence of any interventions and 2) if degene...
Signaling through the interleukin-4 and interleukin-13 receptor complexes regulates cholangiocyte TMEM16A expression and biliary secretion [0.03%]
通过白细胞介素-4和白细胞介素-13受体复合物的信号传导调节胆管细胞TMEM16A表达及胆汁分泌
Amal K Dutta,Kristy Boggs,Al-Karim Khimji et al.
Amal K Dutta et al.
TMEM16A is a Ca2+-activated Cl- channel in the apical membrane of biliary epithelial cells, known as cholangiocytes, which contributes importantly to ductular bile formation. Whereas cholangiocyte TMEM16A activity is regulated by extracellu...
On the nature of high-amplitude propagating pressure waves in the human colon [0.03%]
人结肠高压传播压力波的特征及其产生机制研究
Natalija Milkova,Sean P Parsons,Elyanne Ratcliffe et al.
Natalija Milkova et al.
Characterization of high-amplitude propagating pressure waves (HAPWs or HAPCs) plays a key role in diagnosis of colon dysmotility using any type of colonic manometry. With the introduction of high-resolution manometry, more insight is gaine...
Anti-inflammatory effects of sacral nerve stimulation: a novel spinal afferent and vagal efferent pathway [0.03%]
骶神经刺激的抗炎作用：一种新颖的脊髓传入和迷走传出通路
Lei Tu,Payam Gharibani,Nina Zhang et al.
Lei Tu et al.
Sacral nerve stimulation (SNS) was reported to improve 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. The aim of this study was to investigate whether the SNS anti-inflammatory effect is mediated via the local sacral spl...
Organ-specific lymphatics play distinct roles in regulating HDL trafficking and composition [0.03%]
器官特异性淋巴管在调节HDL转运和组成中发挥不同的作用
Gracia Gracia,Enyuan Cao,Angus P R Johnston et al.
Gracia Gracia et al.
Recently, peripheral lymphatic vessels were found to transport high-density lipoprotein (HDL) from interstitial tissues to the blood circulation during reverse cholesterol transport. This function is thought to be critical to the clearance ...
Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery [0.03%]
胃旁路术后对摄入葡萄糖、蛋白质和脂肪后肠促胰素、胆汁酸及成纤维细胞生长因子-21的反应不同
Christian Zinck Jensen,Kirstine N Bojsen-Møller,Maria S Svane et al.
Christian Zinck Jensen et al.
Postprandial gut hormone responses change after Roux-en-Y gastric bypass (RYGB), and we investigated the impact of glucose, protein, and fat (with and without pancreas lipase inhibition) on plasma responses of gut and pancreas hormones, bil...
Patrick Lundgren,Christoph A Thaiss
Patrick Lundgren
The intestinal commensal microbiome is an important component of host health, in part by contributing an abundance of metabolites that gain access to the systemic circulation. The microbiome thereby influences the physiology of numerous org...
Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus [0.03%]
左旋苯甲硫酸酯对猪食管酸损伤的保护作用
Leandi Krüger,Tiffany A Pridgen,Ellie R Taylor et al.
Leandi Krüger et al.
Esophageal injury from acid exposure related to gastroesophageal reflux disease is a common problem and a risk factor for development of Barrett's esophagus and esophageal adenocarcinoma. Our previous work highlights the benefits of using p...
Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial [0.03%]
分泌素对功能性消化不良和健康胃功能、激素和症状的影响：随机交叉试验
Justin Brandler,Laurence J Miller,Xiao Jing Wang et al.
Justin Brandler et al.
Abnormal gastric accommodation (GA) and gastric emptying contribute to pathophysiology in functional dyspepsia (FD). Secretin is a key regulator of GA in animal studies. Our aim was to study the effects of secretin on gastric motility, sati...
Randomized Controlled Trial
American journal of physiology. Gastrointestinal and liver physiology. 2020 Apr 1;318(4):G635-G645. DOI:10.1152/ajpgi.00371.2019 2020