Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice [0.03%]
N-羧基谷氨酰胺和L-瓜氨酸诱导的尿素生成不需要胰高血糖素受体信号通路：小鼠模型研究
Katrine D Galsgaard,Jens Pedersen,Sasha A S Kjeldsen et al.
Katrine D Galsgaard et al.
Glucagon regulates the hepatic amino acid metabolism and increases ureagenesis. Ureagenesis is activated by N-acetylglutamate (NAG), formed via activation of N-acetylglutamate synthase (NAGS). With the aim to identify the steps whereby gluc...
A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature [0.03%]
肝肠道微生物的故事——肠道菌群影响肝脏疾病机制的研究进展
Mauro Giuffrè,Michele Campigotto,Giuseppina Campisciano et al.
Mauro Giuffrè et al.
Each individual is endowed with a unique gut microbiota (GM) footprint that mediates numerous host-related physiological functions, such as nutrient metabolism, maintenance of the structural integrity of the gut mucosal barrier, immunomodul...
Numb negatively regulates the epithelial-to-mesenchymal transition in colorectal cancer through the Wnt signaling pathway [0.03%]
NUMB通过WNT信号传导通路在结直肠癌中负向调节上皮间质转化
Chi Cheng,Zhenfeng Huang,Ruiyao Zhou et al.
Chi Cheng et al.
Colorectal cancer (CRC) is one of the most common malignant tumors and is associated with a high mortality rate due to the lack of specific biomarkers available for early diagnosis, targeted therapies, and prognostic surveillance. In the pr...
Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin [0.03%]
宿主和环境因素对β-葡萄糖醛酸酶活性的影响及其对肠嗜络胺的含义
Jacinta Walsh,Loreto Olavarria-Ramirez,Gilliard Lach et al.
Jacinta Walsh et al.
The gastrointestinal tract houses a reservoir of bacterial-derived enzymes that can directly catalyze the metabolism of drugs, dietary elements and endogenous molecules. Both host and environmental factors may influence this enzymatic activ...
SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells [0.03%]
SNX27通过与AP-1结合调节DRA活性并介导其在Caco2细胞顶端早期胞内体上的直接回收作用
Karen Bannert,Peggy Berlin,Johannes Reiner et al.
Karen Bannert et al.
DRA (downregulated in adenoma, SLC26A3) and NHE3 (Na+/H+ exchanger 3, SLC9A3) together mediate intestinal electroneutral NaCl absorption. Both transporters contain PDZ (postsynaptic density 95, disc large, zonula occludens 1) binding motifs...
Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice [0.03%]
乙醇喂养加速CPA1 N256K突变小鼠胰腺炎进展
Anna Orekhova,Andrea Geisz,Miklós Sahin-Tóth
Anna Orekhova
Alcoholic pancreatitis is a multifactorial, progressive, inflammatory disorder of the pancreas. Alcohol initiates pancreatitis and promotes its progression in the context of genetic susceptibility and/or other environmental risk factors suc...
Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization [0.03%]
解析肝窦内皮细胞特化的转录决定因素
Willeke de Haan,Cristina Øie,Mohammed Benkheil et al.
Willeke de Haan et al.
Liver sinusoidal endothelial cells (LSECs) are the first liver cells to encounter waste macromolecules, pathogens, and toxins in blood. LSECs are highly specialized to mediate the clearance of these substances via endocytic scavenger recept...
Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions [0.03%]
扰动的线粒体动力学，上皮细胞-微生物相互作用的新方面
Derek M McKay,Nicole L Mancini,Jane Shearer et al.
Derek M McKay et al.
Mitochondria exist in a complex network that is constantly remodeling via the processes of fission and fusion in response to intracellular conditions and extracellular stimuli. Excessive fragmentation of the mitochondrial network because of...
ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis [0.03%]
ROCK1抑制剂稳定E-钙黏着蛋白并改善实验性坏死性小肠结肠炎的屏障功能
Christie Buonpane,Carrie Yuan,Douglas Wood et al.
Christie Buonpane et al.
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of newborns. Although incompletely understood, NEC is associated with intestinal barrier dysfunction. E-cadherin, an adherens junction, is a protein complex integral ...