Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice [0.03%]
药理激活TGR5通过GLP-2依赖性途径促进小鼠肠道生长
Jenna Elizabeth Hunt,Anna Billeschou,Johanne Agerlin Windeløv et al.
Jenna Elizabeth Hunt et al.
Glucagon-like peptide (GLP)-1 and -2-secreting L cells have been shown to express the bile acid receptor Takeda G protein-receptor-5 (TGR5) and increase secretion upon receptor activation. Previous studies have explored GLP-1 secretion foll...
Gut leakage enhances sepsis susceptibility in iron-overloaded β-thalassemia mice through macrophage hyperinflammatory responses [0.03%]
肠道渗漏通过巨噬细胞的过度炎症反应增强铁过载β-地中海贫血小鼠的脓毒症易感性
Peerapat Visitchanakun,Wilasinee Saisorn,Jutamas Wongphoom et al.
Peerapat Visitchanakun et al.
Iron overload induces intestinal-permeability defect (gut leakage), and gut translocation of organismal molecules might enhance systemic inflammation and sepsis severity in patients with thalassemia (Thal). Hence, iron administration in Hbb...
Changes in specific esophageal neuromechanical wall states are associated with conscious awareness of a solid swallowed bolus in healthy subjects [0.03%]
健康受试者中特定食管神经机械壁状态的变化与固体吞咽团块的意识感知相关
Charles Cock,Richard E Leibbrandt,Phil G Dinning et al.
Charles Cock et al.
Esophageal neuromechanical wall states are the physical manifestations of circular muscle inhibition and contraction resulting from neural inputs and leading to bolus propulsion. A novel method infers esophageal neuromechanical wall states ...
Mechanical roles of anterograde and retrograde intestinal peristalses after feeding in a larval fish (Danio rerio) [0.03%]
丹尼氏зи鱼仔鱼摄食后正蠕动和反蠕动对肠机械作用的影响
Kenji Kikuchi,Hyeongtak Noh,Keiko Numayama-Tsuruta et al.
Kenji Kikuchi et al.
Transport in gut is important, not only for digestion, metabolism, and nutrient uptake, but also for microbiotic circumstance in the digestive tract; however, the effects of mixing and pumping in the intestine have not been fully clarified....
Small molecules, big effects: microbial metabolites in intestinal immunity [0.03%]
小分子大作用：肠黏膜免疫中的微生物代谢产物
Lila G Glotfelty,Andrea C Wong,Maayan Levy
Lila G Glotfelty
The mammalian intestine is host to a vast number of microbial organisms. The immune system must balance tolerance with innate and adaptive defense mechanisms to maintain homeostasis with the microbial community. Interestingly, microbial met...
Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis [0.03%]
用于研究艰难梭状芽胞杆菌所致肠炎的类器官模型
Melinda A Engevik,Heather A Danhof,Alexandra L Chang-Graham et al.
Melinda A Engevik et al.
Clostridioides difficile is an important nosocomial pathogen that produces toxins to cause life-threatening diarrhea and colitis. Toxins bind to epithelial receptors and promote the collapse of the actin cytoskeleton. C. difficile toxin act...
Fermentable fibers induce rapid macro- and micronutrient depletion in Toll-like receptor 5-deficient mice [0.03%]
toll-like受体5缺陷小鼠中可发酵纤维引起肠道宏元素除 depleted 微元素的快速消耗
Rachel M Golonka,Beng San Yeoh,Yaqi Li et al.
Rachel M Golonka et al.
Functional fermentable fibers are considered essential for a healthy diet. Recently, we demonstrated that gut microbiota dysbiotic mice fed an inulin-containing diet (ICD) developed hepatocellular carcinoma (HCC) within 6 mo. In particular,...
Helicobacter pylori infection impairs chaperone-assisted maturation of Na-K-ATPase in gastric epithelium [0.03%]
幽门螺杆菌感染会损害胃上皮Na-K-ATP酶的分子伴侣辅助成熟作用
Elizabeth A Marcus,Elmira Tokhtaeva,Jossue L Jimenez et al.
Elizabeth A Marcus et al.
Helicobacter pylori infection always induces gastritis, which may progress to ulcer disease or cancer. The mechanisms underlying mucosal injury by the bacteria are incompletely understood. Here, we identify a novel pathway for H. pylori-ind...
Gabrio Bassotti
Gabrio Bassotti
miR-524-5p inhibits angiogenesis through targeting WNK1 in colon cancer cells [0.03%]
miR-524-5p通过靶向结直肠癌细胞中的WNK1抑制血管生成
Xiang Li,Zitao Li,Ye Zhu et al.
Xiang Li et al.
There is increasing evidence that microRNA (miRNA) abnormity is involved in the occurrence and the development of various malignancies, including colon cancer. MiRNA-524-5p has been reported to possess anticancer activity in various tumors,...