Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity [0.03%]
断奶后接触抗生素会破坏控制结肠运动的肠道神经元的神经化学物质和功能
Lin Y Hung,Pavitha Parathan,Prapaporn Boonma et al.
Lin Y Hung et al.
The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regulate the maturation of the enteric nervous system (ENS). Because microbiota-derived signals that modulate ENS ...
Lipopolysaccharides transport during fat absorption in rodent small intestine [0.03%]
小鼠小肠脂肪吸收过程中脂多糖的转运
Yasutada Akiba,Koji Maruta,Takeshi Takajo et al.
Yasutada Akiba et al.
Lipopolysaccharides (LPS) are potent pro-inflammatory molecules that enter the systemic circulation from the intestinal lumen by uncertain mechanisms. We investigated these mechanisms and the effect of exogenous glucagon-like peptide-2 (GLP...
Experimental analysis of T cell epitopes for designing liver cancer vaccine predicted by system-level immunoinformatics approach [0.03%]
系统水平免疫信息学方法预测的肝癌疫苗实验分析研究
Syed Aun Muhammad,Sidra Zafar,Samana Zahra Rizvi et al.
Syed Aun Muhammad et al.
Liver cancer is a worldwide disease, and, currently, due to the poor prognostic and therapeutic options of liver cancer, we investigated the T cell epitopes as potential therapeutic vaccine candidates to get the benefit of experimental proc...
Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model [0.03%]
补充雌二醇联合睾酮对小鼠睾酮缺乏型非酒精性脂肪肝病免疫调节作用的影响
Takuro Okamura,Masahide Hamaguchi,Ryo Bamba et al.
Takuro Okamura et al.
Nonalcoholic fatty liver disease (NAFLD) is associated with testosterone deficiency. However, NAFLD patients generally do not respond to treatment with testosterone alone. We investigated the innate immune mechanisms underlying the effects ...
HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models [0.03%]
HDAC6依赖的纤毛自噬与人类细胞和小鼠模型中的纤毛丢失及胆管癌生长有关
Estanislao Peixoto,Sujeong Jin,Kristen Thelen et al.
Estanislao Peixoto et al.
Reduced ciliary expression is reported in several tumors, including cholangiocarcinoma (CCA). We previously showed primary cilia have tumor suppressor characteristics, and HDAC6 is involved in ciliary loss. However, mechanisms of ciliary di...
Dopamine D2 receptor activator quinpirole protects against trypsinogen activation during acute pancreatitis via upregulating HSP70 [0.03%]
多巴胺D2受体激动剂quinpirole通过上调HSP70对抗急性胰腺炎时的胰蛋白酶激活
Xin Ye,Xiao Han,Bin Li et al.
Xin Ye et al.
Trypsinogen activation is the hallmark of acute pancreatitis (AP) independent of intra-acinar NF-κB activation and inflammation. We previously found that dopamine (DA) receptor 2 (DRD2) activation controls inflammation during AP via PP2A-d...
Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel [0.03%]
应激诱导的肠道菌群-神经免疫互作在内脏高敏感中的作用机制研究
Isabelle A M van Thiel,Wouter J de Jonge,Isaac M Chiu et al.
Isabelle A M van Thiel et al.
Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). Although the pathophysio...