Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn's disease [0.03%]
转录组学鉴定TMIGD1及其与克罗恩病回肠上皮细胞分化的关系
Yamile Zabana,Violeta Lorén,Eugeni Domènech et al.
Yamile Zabana et al.
Crohn's disease (CD) is a complex and multifactorial illness. There are still considerable gaps in our knowledge regarding its pathophysiology. A transcriptomic approach could shed some light on little-known biological alterations of the di...
Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease [0.03%]
SULT2B1b通过抑制LXR信号促进非酒精性脂肪肝病小鼠模型部分肝切除术后肝脏再生
Xin Zhang,Yuyin Xu,Qianming Bai et al.
Xin Zhang et al.
Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) plays a critical role in hepatic energy homeostasis. Liver X receptors (LXRs) are implicated in multiple physiological functions, including the inhibition of hepatocyte proliferation and regul...
Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors [0.03%]
乙酰胆碱通过胆碱能受体对小鼠回肠起搏器活性产生抑制和兴奋作用及胆碱受体的作用
Julia Yuen Hang Liu,Peng Du,John Anthony Rudd
Julia Yuen Hang Liu
The effect of acetylcholine (ACh) on pacemaking and spontaneous contractions in the gastrointestinal tract is not well characterized. The current study aims to profile the effect of several muscarinic and nicotinic receptor agonists and ant...
Alterations in pancreatic islet cell function in response to small bowel resection [0.03%]
小肠切除后胰岛细胞功能的改变
Cathleen M Courtney,Zeenat A Shyr,Zihan Yan et al.
Cathleen M Courtney et al.
After 50% proximal small bowel resection (SBR) in mice, we have demonstrated hepatic steatosis, impaired glucose metabolism without insulin resistance, and increased pancreatic islet area. We sought to determine the consequences of SBR on p...
LiKang Chin,Neil D Theise,Abigail E Loneker et al.
LiKang Chin et al.
Hepatocellular carcinoma (HCC) is the fourth-leading cause of cancer death in the world. Although most cases occur in stiff, cirrhotic livers, and stiffness is a significant risk factor, HCC can also arise in noncirrhotic livers in the sett...
microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa3 [0.03%]
microRNA-382通过抑制Anxa3来抑制PI3K/Akt信号通路从而抑制胰腺癌的发展进展
Xiaohui Wan,Dongrui Guo,Qi Zhu et al.
Xiaohui Wan et al.
Pancreatic cancer (PC) is a lethal cancer in the digestive system. microRNAs (miRNAs) have been demonstrated to participate in PC progression. In this context, we, thus, aimed to explore the mechanism of miR-382 in epithelial mesenchymal tr...
Microbial metabolite indole-3-propionic acid supplementation does not protect mice from the cardiometabolic consequences of a Western diet [0.03%]
微生物代谢产物吲哚-3-丙酸补充不能保护小鼠免受西方饮食引起的 cardio metabolic后果
Dustin M Lee,Kayl E Ecton,S Raj J Trikha et al.
Dustin M Lee et al.
Emerging evidence suggests that intestinal microbes regulate host physiology and cardiometabolic health, although the mechanism(s) by which they do so is unclear. Indoles are a group of compounds produced from bacterial metabolism of the am...
Cellular maps of gastrointestinal organs: getting the most from tissue clearing [0.03%]
透明化技术在胃肠器官细胞图谱绘制中的应用
Cambrian Y Liu,D Brent Polk
Cambrian Y Liu
The development of modern methods to induce optical transparency ("clearing") in biological tissues has enabled the three-dimensional (3D) reconstruction of intact organs at cellular resolution. New capabilities in visualization of rare cel...
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves [0.03%]
GLP-1和葡萄糖依赖性促胰岛素多肽通过TRPV1和TRPA1表达的感觉神经释放SP
Fahima Mayer,Amanda L Gunawan,Patrick Tso et al.
Fahima Mayer et al.
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells (EECs) in response to nutrient ingestion and lower blood glucose levels by stimulation of insulin secretion and t...