Cristian Ciobanu,Patricia Outeda,William B Guggino et al.
Cristian Ciobanu et al.
Autosomal recessive polycystic kidney disease is associated with cysts derived from abnormal bile ducts. We focused on targeting the cysts and show that a gene therapy for ARPKD that targets the abnormal bile ducts is feasible. We injected ...
Armillariella tabescens polysaccharides alleviate ER stress in 5-FU-induced intestinal epithelial injury and mucositis via ARRB1 modulation [0.03%]
Armillariella tabescens 多糖通过调节ARRB1缓解放线菌素D致肠上皮损伤及黏膜炎引起的内质网应激
Zhongxuan Gui,Yingquan Ye,Mengru Yuan et al.
Zhongxuan Gui et al.
Armillariella tabescens polysaccharides (ATPS) were investigated for their protective effects against 5-Fluorouracil (5-FU)-induced intestinal mucositis in IEC-6 cells and a murine model, with a focus on the role of β-arrestin1 (ARRB1) in ...
Precious Adedayo Adesina,Masato Ooka,Charlotte TeKrony et al.
Precious Adedayo Adesina et al.
Traditional in vitro intestinal model systems frequently fail to accurately replicate human intestinal physiology for absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessments. These limitations, coupled with the gro...
Genetic Disruption of hnRNPI Reveals a Microbial-Metabolic Axis in Colitis-Associated Cancer [0.03%]
基因hnRNPI的遗传干扰揭示了 colitis-相关癌症中的微生物-代谢轴
Yohannes Gemechu,Mengistu Lemecha
Yohannes Gemechu
Female ethanolamine phosphate phospholyase knockout mice resisted high-fat diet-induced obesity with attenuated hepatic cholesterol deposition [0.03%]
乙醇胺磷酸酶敲除小鼠因高脂饮食导致的肥胖和肝脏胆固醇沉积减少现象
Kholoud Alaa Elmihi,Kelly-Ann Leonard,Randy Nelson et al.
Kholoud Alaa Elmihi et al.
Ethanolamine phosphate phospholyase (ETNPPL) is an enzyme that irreversibly degrades phospho-ethanolamine (p-ETN), an intermediate in the Kennedy pathway of phosphatidylethanolamine (PE) synthesis. Whole-body knockout Etnppl mice were fed a...
Naomi Chege,Constance A M Finney
Naomi Chege
The intestinal epithelium is in continual flux. It must balance maintaining a healthy microbiota with detecting and destroying intestinal pathogens. Intestinal stem cells (ISCs), which sit in the crypts below the intestinal villi, control t...
Energy status alters intestinal function and the gut microbiota during consecutive days of high energy demands [0.03%]
能量状态改变连续高能耗需求下的肠功能和肠道微生物群
Cassandra Suther,Adrienne Hatch-McChesney,Jillian T Allen et al.
Cassandra Suther et al.
Host-gut microbiota interactions may impact intestinal function during sustained periods of high energy demands. Whether energy status, reflecting the balance between energy intake and expenditure, impacts those interactions is unknown. Thi...
Maternal Western Diet Increases Inflammatory Markers and Decreases Barrier Function of Offspring in Papio Anubis [0.03%]
母体西式饮食增加雌性非洲绿猴后代的炎症标志物并降低其屏障功能
Grant H Gershner,Alena Golubkova,Cody Dalton et al.
Grant H Gershner et al.
Introduction: The Western diet (WD) has been associated with various pathologies, largely due to chronic inflammatory responses triggered by insulin spikes and excess cholesterol. However, the effects of maternal WD on offspring are current...