Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease [0.03%]
线粒体氧化损伤在非酒精性脂肪肝病中的关键作用
Waleska Dornas,Detlef Schuppan
Waleska Dornas
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease worldwide. NAFLD is tightly linked to the metabolic syndrome, insulin resistance, and oxidative stress. Globally, its inflammatory form, nonalcoholic steat...
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone [0.03%]
FXR-OATP1A2调节的胆汁酸重吸收是胆固醇结石形成的主要因素
Jingli Cai,Zhaowen Wang,Guiming Chen et al.
Jingli Cai et al.
The purpose of this study was to demonstrate the aberrant metabolism of bile acids in patients with cholesterol gallstone and explore for its underlying mechanisms. The composition of bile acids collected from the patients with cholelithias...
Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea [0.03%]
糖皮质激素和由血液及糖皮质激素诱导的激酶1是CFTR在天然肠中的强力调节因子：对压力引起的腹泻的意义
Md Kaimul Ahsan,Leandra Figueroa-Hall,Vanessa Baratta et al.
Md Kaimul Ahsan et al.
Nongenomic glucocorticoid (GC) and serum- and glucocorticoid-inducible kinase 1 (SGK1) signaling regulate ion transport, but CFTR has not been investigated in the intestine. We examined GC, SGK1, and phosphatidylinositol 3-kinase (PI3K) kin...
Parallel intermediate conductance K+ and Cl- channel activity mediates electroneutral K+ exit across basolateral membranes in rat distal colon [0.03%]
大鼠远端结肠中介导经侧膜电中性钾转运的平行中间钾通道和氯通道活性
Shabina Rehman,Karthikeyan Narayanan,Andrew J Nickerson et al.
Shabina Rehman et al.
Transepithelial K+ absorption requires apical K+ uptake and basolateral K+ exit. In the colon, apical H+-K+-ATPase mediates cellular K+ uptake, and it has been suggested that electroneutral basolateral K+ exit reflects K+-Cl- cotransporter-...
Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs [0.03%]
健康清醒猪的肠道、肝脏、肌肉和肾脏组织床外源代谢物的净释放和摄取
Kelly E Mercer,Gabriella A M Ten Have,Lindsay Pack et al.
Kelly E Mercer et al.
Xenometabolites from microbial and plant sources are thought to confer beneficial as well as deleterious effects on host physiology. Studies determining absorption and tissue uptake of xenometabolites are limited. We utilized a conscious ca...
Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer [0.03%]
胃癌中通过糖皮质激素反应性增强子损伤导致GKN1和GKN2表达丢失协调发生
Sharleen Chung Nien Chin,Louise O&#x;Connor,Michelle Scurr et al.
Sharleen Chung Nien Chin et al.
Gastrokines (GKNs) are anti-inflammatory proteins secreted by gastric epithelial (surface mucous and pit) cells, with their aberrant loss of expression causally linked to premalignant inflammation and gastric cancer (GC). Transcriptional me...
Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR [0.03%]
透明质酸通过TLR4和PGE2转激活EGFR促进Lgr5+干细胞增殖和隐窝分裂
Terrence E Riehl,David Alvarado,Xueping Ee et al.
Terrence E Riehl et al.
Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously demonstrated that both CD44 and TLR4, but predominately TLR4, mediated HA stimulation of Lgr5+ stem cell pro...
Switching of cargo sorting from the constitutive to regulated secretory pathway by the addition of cystatin D sequence in salivary acinar cells [0.03%]
唾液腺导管细胞中添加半胱氨酸蛋白酶抑制剂D序列能使胞内运输方式从组成型转换为调节型分泌路径
Junko Fujita-Yoshigaki,Megumi Yokoyama,Osamu Katsumata-Kato
Junko Fujita-Yoshigaki
The mechanism for segregation of cargo proteins into the regulated and constitutive secretory pathways in exocrine cells remains to be elucidated. We examined the transport of HaloTag proteins fused with full-length cystatin D (fCst5-Halo) ...
Hyperthermia-induced changes in liver physiology and metabolism: a rationale for hyperthermic machine perfusion [0.03%]
肝脏生理和代谢在高温下的改变以及其对高温灌注的指导意义
Adam M Thorne,Rinse Ubbink,Isabel M A Brüggenwirth et al.
Adam M Thorne et al.
Liver transplantation is the standard treatment for end-stage liver disease. However, due to the ongoing disparity between supply and demand for optimal donor organs, there is increasing usage of extended criteria donor organs, including st...
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites [0.03%]
基于丰富微生物衍生代射物的代谢组平台发现UC Davis 2型糖尿病模型大鼠的 Xenometabolite标志物
Kelly E Mercer,Laxmi Yeruva,Lindsay Pack et al.
Kelly E Mercer et al.
The gut microbiome has the potential to create or modify xenometabolites (i.e., nonhost-derived metabolites) through de novo synthesis or modification of exogenous and endogenous compounds. While there are isolated examples of xenometabolit...