Gastrointestinal organoids: a next-generation tool for modeling human development [0.03%]
胃肠器官体：模拟人类发育的下一代工具
Akaljot Singh,Holly M Poling,Jason R Spence et al.
Akaljot Singh et al.
Gastrointestinal organoids are an exciting new tool for modeling human development, physiology, and disease in human tissue. Derived from pluripotent stem cells, gastrointestinal organoids consist of epithelial and mesenchymal cells organiz...
The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19 [0.03%]
新型冠状病毒肺炎患者的胃肠症状的发生机制及处理原则
Qing Ye,Bili Wang,Ting Zhang et al.
Qing Ye et al.
In addition to the typical respiratory response, new coronavirus disease 2019 (COVID-19) is also associated with very common gastrointestinal symptoms. Cases with gastrointestinal symptoms are more likely to be complicated by liver injury a...
Associations of gastric volumes, ingestive behavior, calorie and volume intake, and fullness in obesity [0.03%]
胃体积、进食行为、肥胖患者摄入的卡路里和体积与其饱腹感之间的关系
Priya Vijayvargiya,Victor Chedid,Xiao Jing Wang et al.
Priya Vijayvargiya et al.
Whereas gastric emptying significantly predicts calorie intake, the association between gastric capacity and satiation and satiety is unclear. To study the associations between gastric volumes and ingestive behaviors with satiation and sati...
Role of glucuronidated 25-hydroxyvitamin D on colon gene expression in mice [0.03%]
小鼠结肠基因表达中葡萄糖醛酸化25-羟基维生素D的作用
Carmen J Reynolds,Nicholas J Koszewski,Ronald L Horst et al.
Carmen J Reynolds et al.
25-Hydroxyvitamin D3-3β-glucuronic acid (25OHD-Gluc) is produced in the liver and is a constituent of human blood and bile. Bacterial glucuronidases (GUS) in mammalian digestive microbiota cleave glucuronide conjugates, such as 25OHD-Gluc,...
Michael P Verzi,Ramesh A Shivdasani
Michael P Verzi
To fulfill the lifelong need to supply diverse epithelial cells, intestinal stem cells (ISCs) rely on executing accurate transcriptional programs. This review addresses the mechanisms that control those programs. Genes that define cell beha...
Grading TESI: Crypt and villus formation in tissue-engineered small intestine alters with stem/progenitor cell source [0.03%]
基于不同干细胞来源的组织工程小肠中隐窝和绒毛结构的构建规律不同
Elizabeth A Gilliam,Christopher R Schlieve,Kathryn L Fowler et al.
Elizabeth A Gilliam et al.
The small intestine has a remarkable ability to enhance its absorptive and digestive surface area through the formation of villi, a process known as villification. We sought to learn whether developing mouse and human tissue-engineered smal...
Broad-spectrum antibiotics alter the microbiome, increase intestinal fxr, and decrease hepatic steatosis in zebrafish short bowel syndrome [0.03%]
广谱抗生素通过改变肠道菌群增加FXR活性减少小肠综合征斑马鱼的肝脂肪变性
Kathryn M Maselli,Kristin Gee,Mubina Isani et al.
Kathryn M Maselli et al.
Short bowel syndrome (SBS) is associated with changes in the intestinal microbiome and marked local and systemic inflammation. There is also a late complication of SBS, intestinal failure associated liver disease (IFALD) in which hepatic st...
Early normalization of reduced urea synthesis capacity after direct-acting antiviral therapy in hepatitis C cirrhosis [0.03%]
直接抗病毒治疗后肝硬化患者尿素合成能力下降的早期恢复正常化现象
Tea Lund Laursen,Thomas Damgaard Sandahl,Konstantin Kazankov et al.
Tea Lund Laursen et al.
Laursen TL, Sandahl TD, Kazankov K, Eriksen PL, Kristensen LH, Holmboe CH, Laursen AL, Vilstrup H, Grønbæk H. Early normalization of reduced urea synthesis capacity after direct-acting antiviral therapy in hepatitis C cirrhosis. Am J Phys...
Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia [0.03%]
奥贝胆酸改善妊娠高胆汁淤积症小鼠模型的胎儿胆汁酸谱
Vanessa Pataia,Saraid McIlvride,Georgia Papacleovoulou et al.
Vanessa Pataia et al.
Intrahepatic cholestasis of pregnancy (ICP) is characterized by elevated maternal circulating bile acid levels and associated dyslipidemia. ICP leads to accumulation of bile acids in the fetal compartment, and the elevated bile acid concent...
Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids [0.03%]
窄谱抗菌药利尼唑胺用于治疗难辨梭菌感染可增强依赖微生物群的胆汁酸的保存
Xi Qian,Karin Yanagi,Anne V Kane et al.
Xi Qian et al.
Antibiotic treatment is a standard therapy for Clostridioides difficile infection, but dysbiosis of the gut microbiota due to antibiotic exposure is also a major risk factor for the disease. Following an initial episode of C. difficile infe...