Sustained laryngeal transient receptor potential vanilloid 1 activation inhibits mechanically induced swallowing in anesthetized rats [0.03%]
持续的喉部瞬时受体电位香草酸1激活抑制了麻醉大鼠的机械诱导吞咽
Midori Yoshihara,Takanori Tsujimura,Taku Suzuki et al.
Midori Yoshihara et al.
A major component of gastric acid is hydrochloric acid (HCl), which can activate transient receptor potential vanilloid 1 (TRPV1). In the present study, we investigated how sustained laryngeal TRPV1 activation affects the frequency of the s...
Enlightening the frontiers of neurogastroenterology through optogenetics [0.03%]
通过光遗传学照亮神经胃肠病学的前沿领域
Anthony C Johnson,Tijs Louwies,Casey O Ligon et al.
Anthony C Johnson et al.
Neurogastroenterology refers to the study of the extrinsic and intrinsic nervous system circuits controlling the gastrointestinal (GI) tract. Over the past 5-10 yr there has been an explosion in novel methodologies, technologies and approac...
A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood [0.03%]
一种小儿炎症性肠病的小鼠模型导致成年后微生物群-肠道-大脑轴缺陷
Eloisa Salvo,Patricia Stokes,Ciara E Keogh et al.
Eloisa Salvo et al.
Inflammatory bowel diseases (IBDs) are chronic intestinal diseases, frequently associated with comorbid psychological and cognitive deficits. These neuropsychiatric effects include anxiety, depression, and memory impairments that can be see...
Stimulus intensity-dependent recruitment of NaV1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus [0.03%]
支配食道的迷走C纤维末端动作电位起始中NaV1通道亚基募集的刺激强度依赖性
Fei Ru,Nikoleta Pavelkova,Jeffrey L Krajewski et al.
Fei Ru et al.
We investigated voltage-gated sodium channel (NaV1) subunits that regulate action potential initiation in the nerve terminals of vagal nodose C-fibers innervating the esophagus. Extracellular single fiber recordings were made from the nodos...
Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease [0.03%]
硫酸酯酶2基因敲除通过减少非酒精性脂肪肝疾病小鼠模型中的steatohepatitis和纤维化发挥作用
Tae Hyo Kim,Bubu A Banini,Faizal Z Asumda et al.
Tae Hyo Kim et al.
Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes. We used a murine model of diet-induced steatohepatitis to assess the effect of SU...
Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells [0.03%]
胰腺外分泌细胞中microRNA-200a-3p调节硫胺素转运体-1基因翻译后表达的作用机制研究
Kalidas Ramamoorthy,Kasin Yadunandam Anandam,Tomoya Yasujima et al.
Kalidas Ramamoorthy et al.
The water-soluble vitamin B1 (thiamin) plays essential roles in normal metabolism and function of all human/mammalian cells, including the pancreatic acinar cells (PACs). PACs obtain thiamin from their surrounding circulation via transport ...
Defense mechanisms to increasing back pressure for hepatic oxygen transport and venous return in porcine fecal peritonitis [0.03%]
猪粪性腹膜炎时增加肝脏氧运输和静脉回流的防御机制
Shengchen Liu,Pedro Paulo Zanella do Amaral Campos,Daniela Casoni et al.
Shengchen Liu et al.
High central venous pressure (CVP) acutely decreases venous return. How this affects hepatic oxygen transport in sepsis remains unclear. The aim of this study was to evaluate the effects of repeated increases in CVP via standard nursing pro...
TNF-α, IL-17, and IL-22 production in the rectal mucosa of nonceliac wheat sensitivity patients: role of adaptive immunity [0.03%]
非乳糜泻小麦敏感患者直肠粘膜中TNF-α，IL-17和IL-22的产生：适应性免疫的作用
Pasquale Mansueto,Diana Di Liberto,Francesca Fayer et al.
Pasquale Mansueto et al.
In recent years, a new gluten- or wheat-related disease has emerged, a condition labeled "nonceliac gluten sensitivity" (NCGS) or "nonceliac wheat sensitivity" (NCWS). NCWS pathogenesis is still uncertain and attributed to very different me...
Randomized Controlled Trial
American journal of physiology. Gastrointestinal and liver physiology. 2020 Sep 1;319(3):G281-G288. DOI:10.1152/ajpgi.00104.2020 2020
Talk about micromanaging! Role of microRNAs in intestinal barrier function [0.03%]
微管理！microRNA在肠屏障功能中的作用
Rana Al-Sadi,Jessica Engers,Raz Abdulqadir
Rana Al-Sadi
Defective intestinal tight-junction (TJ) barrier has been implicated in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), and other inflammatory conditions of the gut. The role...