Role of an active reserve stem cell subset of enteroendocrine cells in intestinal stem cell dynamics and the genesis of small intestinal neuroendocrine tumors [0.03%]
肠内分泌细胞作为活跃的reserve干细胞在肠道干细胞动力学及小肠神经内分泌肿瘤发生中的作用
Yoshitatsu Sei,Jianying Feng,Xilin Zhao et al.
Yoshitatsu Sei et al.
Small intestinal neuroendocrine tumors (SI-NET) are serotonin-secreting well-differentiated neuroendocrine tumors of putative enterochromaffin (EC) cell origin. Recent studies recognize a subset of EC cells that is label-retaining at the +4...
Inhibition of GSK-3β restores delayed gastric emptying in obesity-induced diabetic female mice [0.03%]
GSK-3β的抑制恢复了肥胖诱导的糖尿病雌性小鼠的胃排空延迟问题
Chethan Sampath,Shanthi Srinivasan,Michael L Freeman et al.
Chethan Sampath et al.
Diabetic gastroparesis (DG) is a clinical syndrome characterized by delayed gastric emptying (DGE). Loss of nuclear factor erythroid 2-related factor 2 (Nrf2) is associated with reduced neuronal nitric oxide synthase-α (nNOSα)-mediated ga...
An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase [0.03%]
非酒精性脂肪肝病中失调的脂质代谢概述，特别关注溶酶体酸脂酶
Simone Carotti,Katia Aquilano,Francesco Valentini et al.
Simone Carotti et al.
Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver steatosis develops as a result of the deregulation of pathway...
Duodenal-jejunal bypass improves nonalcoholic fatty liver disease independently of weight loss in rodents with diet-induced obesity [0.03%]
十二指肠空肠旁路独立于减重而改善饮食引起的肥胖啮齿动物的非酒精性脂肪肝病
Giulia Angelini,Lidia Castagneto-Gissey,James Casella-Mariolo et al.
Giulia Angelini et al.
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver-related mortality. NAFLD is associated with obesity, hepatic fat accumulation, and insulin resistance, all of which contribute to its pathophysiology. Weight-loss is...
Ssu-Chi Chen,Kaori Futaba,Wing Wa Leung et al.
Ssu-Chi Chen et al.
Fecal continence is maintained by several mechanisms including anatomical factors, anorectal sensation, rectal compliance, stool consistency, anal muscle strength, mobility, and psychological factors. The homeostatic balance is easily distu...
Claudio Bernardazzi,Hua Xu,Huan Tong et al.
Claudio Bernardazzi et al.
The loss of the intestinal Na+/H+ exchanger isoform 8 (NHE8) results in an ulcerative colitis-like condition with reduction of mucin production and dysbiosis, indicating that NHE8 plays an important role in intestinal mucosal protection. Th...
Relationship between distension-contraction waveforms during esophageal peristalsis: effect of bolus volume, viscosity, and posture [0.03%]
食管蠕动过程中扩张-收缩波形之间的关系：团体积、粘度和体位的影响
Ravinder K Mittal,Kazumasa Muta,Melissa Ledgerwood-Lee et al.
Ravinder K Mittal et al.
High-resolution esophageal manometry (HRM) in its current form assesses only the contraction phase of peristalsis. Degree of esophageal distension ahead of contraction is a surrogate of relaxation and can be measured from intraluminal esoph...
The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis [0.03%]
美国生活方式引起的肥胖综合征饮食在啮齿类动物的雄性和雌性中再现了非酒精性脂肪肝病和非酒精性脂肪肝炎的临床和转录组特征
Shelley E Harris,Toryn M Poolman,Anastasia Arvaniti et al.
Shelley E Harris et al.
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the progression to nonalcoholic steatohepatitis (NASH) and increased risk of hepatocellular carcinoma remain poorly understood. Additionally, there is increasing recognition o...
Microbiota on biotics: probiotics, prebiotics, and synbiotics to optimize growth and metabolism [0.03%]
生物中的微生物群落：益生菌、益生元和合生元以优化生长和代谢
Price T Edwards,Purna C Kashyap,Geoffrey A Preidis
Price T Edwards
The early stages of the metagenomics era produced countless observational studies linking various human diseases to alterations in the gut microbiota. Only recently have we begun to decipher the causal roles that gut microbes play in many o...
Acetaldehyde suppresses HBV-MHC class I complex presentation on hepatocytes via induction of ER stress and Golgi fragmentation [0.03%]
乙醛通过诱导内质网应激和高尔基体断裂抑制肝细胞上HBV- MHC I类复合物的呈现
Murali Ganesan,Saumi Mathews,Edward Makarov et al.
Murali Ganesan et al.
Alcohol consumption worsens hepatitis B virus (HBV) infection pathogenesis. We have recently reported that acetaldehyde suppressed HBV peptide-major histocompatibility complex I (MHC class I) complex display on hepatocytes, limiting recogni...