Effects of dietary components on intestinal permeability in health and disease [0.03%]
饮食成分对健康和疾病状态下肠道通透性的影响
Katayoun Khoshbin,Michael Camilleri
Katayoun Khoshbin
Altered intestinal permeability plays a role in many pathological conditions. Intestinal permeability is a component of the intestinal barrier. This barrier is a dynamic interface between the body and the food and pathogens that enter the g...
Early life interaction between the microbiota and the enteric nervous system [0.03%]
微生物群与肠神经系统早期生活的相互作用
Jaime P P Foong,Lin Y Hung,Sabrina Poon et al.
Jaime P P Foong et al.
Recent studies on humans and their key experimental model, the mouse, have begun to uncover the importance of gastrointestinal (GI) microbiota and enteric nervous system (ENS) interactions during developmental windows spanning from concepti...
hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223 [0.03%]
hsa_circRNA_001587通过结合microRNA-223上调SLC4A4表达以抑制胰腺癌细胞的迁移，侵袭和血管生成
Xiutian Zhang,Peng Tan,Yuan Zhuang et al.
Xiutian Zhang et al.
Pancreatic cancer (PC) is a malignant tumor that is difficult to diagnose and treat. Circular RNAs (circRNAs) are biomarkers that may be used to diagnose certain cancers or act as targets for cancer treatment. We aimed to explore the functi...
Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats [0.03%]
麻醉大鼠由碳酸水引发吞咽过程的开端中对辣椒素敏感的神经的作用
Kojun Tsuji,Takanori Tsujimura,Shogo Sakai et al.
Kojun Tsuji et al.
Capsaicin powerfully evokes the swallowing reflex and is a known therapeutic agent for improving dysphagia and preventing aspiration pneumonia. However, the role of capsaicin-sensitive nerves in the initiation of swallowing evoked by variou...
Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure [0.03%]
重症急性胰腺炎：连接全身炎症与多器官衰竭的血管通透性模型
Nicole L Komara,Pedram Paragomi,Phil J Greer et al.
Nicole L Komara et al.
Severe acute pancreatitis (SAP) includes persistent systemic inflammation (SIRS) and multiorgan failure (MOF). The mechanism of transition from SIRS to MOF is unclear. We developed a fluid compartment model and used clinical data to test pr...
Endoscopic ultrasound-guided sampling and profiling of portal circulation in human patients for metabolic research studies and biomarker assessment [0.03%]
用于代谢研究和生物标志物评估的人体患者经内镜超声引导的采样及门静脉循环分析
Marvin Ryou,Nicholas Stylopoulos
Marvin Ryou
Portal and hepatic circulation can now be safely accessed using endoscopic ultrasound (EUS). EUS-guided needle access of the portal vein is performed clinically at select tertiary centers for measurement of portal pressure gradients in pati...
Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine [0.03%]
驱动向上的动力： Cajal间质细胞如何改变发育中肠道的运动模式
Nicolas R Chevalier,Yanis Ammouche,Anthony Gomis et al.
Nicolas R Chevalier et al.
The first contractile waves in the developing embryonic gut are purely myogenic; they only involve smooth muscle. Here, we provide evidence for a transition from smooth muscle to interstitial cell of Cajal (ICC)-driven contractile waves in ...
Yogesh Bhattarai,Purna C Kashyap
Yogesh Bhattarai
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by motor and gastrointestinal (GI) deficits. Despite its prevalence, the pathophysiology of PD is not well understood. Recent studies highlight the role of gut m...
High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis [0.03%]
高脂饮食诱导缺乏CYP2A5和PPARα的小鼠出现纤维化：一种与脂肪性肝炎相关的纤维化的全新模型
Xue Chen,George K Acquaah-Mensah,Krista L Denning et al.
Xue Chen et al.
Obesity is linked to nonalcoholic steatohepatitis. Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid metabolism. Cytochrome P-450 2A5 (CYP2A5) is a potential antioxidant and CYP2A5 induction by ethanol is CYP2E1 depende...
Exercise and intestinal permeability: another form of exercise-induced hormesis? [0.03%]
运动与肠道通透性：另一种形式的运动引起的适应性反应？
Bryant H Keirns,Nicholas A Koemel,Christina M Sciarrillo et al.
Bryant H Keirns et al.
Regular aerobic exercise has numerous benefits on human physiology, arguably by serving as a hormetic stressor resulting in positive adaptations over time. It has long been known that aerobic exercise at a variety of intensities and duratio...