Nasser Abdullah,Manon Defaye,Christophe Altier
Nasser Abdullah
The gut-brain axis is a coordinated communication system that not only maintains homeostasis, but significantly influences higher cognitive functions and emotions, as well as neurological and behavioral disorders. Among the large population...
Repetitive Antegrade Contractions: A novel response to sustained esophageal distension is modulated by cholinergic influence [0.03%]
反复的前向收缩：对持续的食管扩张的一种新的反应受到胆碱能影响的调节
Dustin A Carlson,Wenjun Kou,Melina Masihi et al.
Dustin A Carlson et al.
Background & aims: A unique motor response to sustained esophageal distension, repetitive antegrade contractions (RACs), is observed using functional luminal imaging probe (FLIP) panometry. However, physiologic mechanisms...
Sameena Wani,Ivy Ka Man Law,Charalabos Pothoulakis
Sameena Wani
Exosomes represent secretory membranous vesicles used for the information exchange between cells and organ-to-organ communication. Exosome crosstalk mechanisms are involved in the regulation of several inflammatory bowel disease (IBD)-assoc...
The new microbiology: cultivating the future of microbiome-directed medicine [0.03%]
新微生物学：塑造微生物导向药物的未来
Connie W Y Ha,Suzanne Devkota
Connie W Y Ha
The discovery of human-associated microscopic life forms has captivated the scientific community since their first documentation in the 17th century. Subsequent isolation and cultivation of microorganisms have spurred great leaps in medicin...
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans [0.03%]
小鼠和人类在生命早期经历逆境后，肥大细胞、胶质细胞和神经元之间的组胺依赖相互作用会发生改变
Jonathon L McClain,Elvio A Mazzotta,Nidia Maradiaga et al.
Jonathon L McClain et al.
Early-life adversity contributes to the development of functional bowel disorders later in life through unresolved mechanisms. Here, we tested the hypothesis that early-life adversity alters anatomical and functional interactions between ma...
The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis [0.03%]
活动克罗恩病和溃疡性结肠炎的上皮组织中五羟色胺摄取转运体减少
Jonas Woll Jørandli,Silje Thorsvik,Helene Kolstad Skovdahl et al.
Jonas Woll Jørandli et al.
Serotonin is a highly conserved and ubiquitous signaling molecule involved in a vast variety of biological processes. A majority of serotonin is produced in the gastrointestinal epithelium, where it is suggested to act as a prominent regula...
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG) [0.03%]
FGF15在介导小鼠垂直袖状胃切除术(VSG)的代谢结果中的作用评估
Andriy Myronovych,Jashdeep Bhattacharjee,Rosa-Maria Salazar-Gonzalez et al.
Andriy Myronovych et al.
Vertical sleeve gastrectomy (VSG) is the best current therapy for remission of obesity and its co-morbidities. It is understood to alter the enterohepatic circulation of bile acids in vivo. Fibroblast growth factor 19 (FGF19) in human and i...
Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids [0.03%]
胆酸肠肝循环回肠中断的代谢后果
Ivo P van de Peppel,Henkjan J Verkade,Johan W Jonker
Ivo P van de Peppel
The enterohepatic circulation of bile acids comprises a tightly regulated process of hepatic bile acid secretion, intestinal reabsorption and transport back to the liver. Disruption of this process has significant consequences for gastroint...
Hepatic bile formation: bile acid transport and water flow into the canalicular conduit [0.03%]
肝胆汁形成：胆汁酸转运和导管内的水流动
Norman B Javitt
Norman B Javitt
Advances in molecular biology identifying the many carrier-mediated organic anion transporters and advances in microscopy that have provided a more detailed anatomy of the canalicular conduit make updating the concept of osmotically determi...
Yunxia Yang,Jianfa Zhang
Yunxia Yang
Circadian rhythms are biological systems that synchronize cellular circadian oscillators with the organism's daily feeding-fasting or rest-activity cycles in mammals. Circadian rhythms regulate nutrient absorption and utilization at the cel...