Expression of the regulated isoform of the electrogenic Na+/HCO3- cotransporter, NBCe1, is enriched in pacemaker interstitial cells of Cajal [0.03%]
调节型电中性Na+/HCO3-_同向转运体NBCe1在起搏中间部位卡哈尔细胞中的表达增强
Maria-Gabriela Colmenares Aguilar,Amelia Mazzone,Seth T Eisenman et al.
Maria-Gabriela Colmenares Aguilar et al.
Interstitial cells of Cajal (ICCs) generate electrical slow waves, which are required for normal gastrointestinal motility. The mechanisms for generation of normal pacemaking are not fully understood. Normal gastrointestinal contractility- ...
Maternal high-fat diet activates hepatic interleukin-4 in rat male offspring accompanied by increased eosinophil infiltration [0.03%]
高脂饮食可激活子代大鼠肝细胞中的IL-4并增加嗜酸性粒细胞浸润
Huan Wang,Guanying Bianca Xu,Hong Chen et al.
Huan Wang et al.
Interleukin-4 (IL-4) is activated as an immune response during infection or tissue injury. Epigenetic programming of maternal high-fat (HF) diet has long-term effects in the offspring. In the present study, we investigated the epigenetic re...
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo [0.03%]
短链脂肪酸丁酸盐可提高不成熟肠道屏障功能基因对炎症的反应，丁酸盐是母乳代谢物，在体内和体外均可观察到此现象。
Yanan Gao,Brittany Davis,Weishu Zhu et al.
Yanan Gao et al.
Infants born under 1,500 g have an increased incidence of necrotizing enterocolitis in the ileum and the colon, which is a life-threatening intestinal necrosis. This is in part due to excessive inflammation in the immature intestine to colo...
N J Spencer,M Costa,T J Hibberd et al.
N J Spencer et al.
The primary functions of the gastrointestinal (GI) tract are to absorb nutrients, water, and electrolytes that are essential for life. This is accompanied by the capability of the GI tract to mix ingested content to maximize absorption and ...
Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa [0.03%]
肠道微生物群和上皮细胞产生的硫化氢及其对结肠和直肠粘膜的影响
François Blachier,Mireille Andriamihaja,Pierre Larraufie et al.
François Blachier et al.
Among bacterial metabolites, hydrogen sulfide (H2S) has received increasing attention. The epithelial cells of the large intestine are exposed to two sources of H2S. The main one is the luminal source that results from specific bacteria met...
Liver Injury Impaired 25-Hydroxylation of Vitamin D Suppresses Intestinal Paneth Cell defensins, leading to Gut Dysbiosis and Liver Fibrogenesis [0.03%]
肝损伤通过影响维D的25-羟化作用抑制肠潘氏细胞抗菌肽的产生，导致肠道菌群失调和肝纤维化的发生
Pengfei Wu,Ruofei Zhang,Mei Luo et al.
Pengfei Wu et al.
Vitamin D deficiency is co-prevalent with various liver diseases including cirrhosis, while the underlying mechanism remains elusive. Vitamin D receptor (VDR) is abundantly expressed in the distal region of small intestine, where the Paneth...
Spinal neuron-glia-immune interaction in cross-organ sensitization [0.03%]
脊髓神经胶质细胞-免疫相互作用在跨器官敏感化中的作用
Liya Y Qiao,Namrata Tiwari
Liya Y Qiao
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), historically considered as regional gastrointestinal disorders with heightened colonic sensitivity, are increasingly recognized to have concurrent dysfunction of other vis...
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip [0.03%]
肠芯片中流体剪切应力增强空肠类器官的分化
Jianyi Yin,Laxmi Sunuwar,Magdalena Kasendra et al.
Jianyi Yin et al.
There is increasing evidence that the study of normal human enteroids duplicates many known aspects of human intestinal physiology. However, this epithelial cell-only model lacks the many nonepithelial intestinal cells present in the gastro...
Differential expression of full-length and NH2 terminally truncated FAM134B isoforms in normal physiology and cancer [0.03%]
正常生理学和癌症中全长和NH2氨基末端截短的FAM134B剪接变异体的差异表达
Umur Keles,Evin Iscan,Huriye Erbak Yilmaz et al.
Umur Keles et al.
Selective autophagy of the endoplasmic reticulum (ER), namely ER-phagy, is mediated by ER-localized receptors, which are recognized and sequestered by GABARAP/LC3B-decorated phagophores and transferred to lysosomes for degradation. Being on...
LINC00511-dependent inhibition of IL-24 contributes to the oncogenic role of HNF4α in colorectal cancer [0.03%]
LINC00511依赖性对IL-24的抑制作用有助于HNF4α在结直肠癌中的致癌作用
Yanyan Lu,Yanan Yu,Fuguo Liu et al.
Yanyan Lu et al.
Hepatocyte nuclear factor 4 α (HNF4α) is an important transcription factor that acts as a pro-proliferative mediator during tumorigenesis, yet its function in colorectal cancer (CRC) remain unclear. Hence, this study aims to explore roles...