Dynamic Cholangiocyte Responses in a Murine Model of Reversible Cholestasis: Macrophage Remodeling and NF-Y Mediated TGFβ1 Expression [0.03%]
可逆性胆汁淤积小鼠模型中胆管细胞的动态反应：巨噬细胞重塑和NF-Y介导TGFβ1表达
Kirsta E Olson,Anuradha Krishnan,Patrick Splinter et al.
Kirsta E Olson et al.
During cholestasis, cholangiocytes become activated, promoting macrophage-associated periductal infiltration and fibrosis. The cholangiocyte specific mechanisms responsible for these processes are unclear. To gain insight into the cholangio...
Pioglitazone Reduces Hepatic Alpha-1 Antitrypsin Accumulation Through Autophagy and AMPK Activation in Alpha-1 Antitrypsin Deficient Mice [0.03%]
吡格列酮通过自噬和AMPK活化减少肝积累α1抗胰蛋白酶敲除小鼠中α1抗胰蛋白酶累积
Yuanqing Lu,Regina Oshins,Nesmine R Maptue et al.
Yuanqing Lu et al.
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder characterized by accumulation of misfolded Z α-1 antitrypsin (ZAAT) in hepatocytes, leading to liver injury and metabolic dysfunction. There is no therapy to reduce ZA...
Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice [0.03%]
CPA1错误折叠突变可加速KC小鼠胰腺癌前病变发展
Alexandra Demcsák,Miklós Sahin-Tóth
Alexandra Demcsák
Germline mutations in the CPA1 gene encoding carboxypeptidase A1 were found in association with chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). The mutations increase pancreatic disease risk, presumably, by causing proenzy...
Temporal Transcriptional and Functional Dynamics of Jejunal Mucosal Response to Early Weaning in Piglets [0.03%]
仔猪早期断奶对其空肠粘膜转录和功能的动态影响
Ty M Mitchell,Heather Ann Moeser,Adam J Moeser
Ty M Mitchell
Early-life adversity, including abrupt weaning, imposes significant psychosocial and environmental stress during a critical window of gastrointestinal (GI) development, leading to long-term consequences for gut function and disease suscepti...
Probiotic-Mediated Regulation of Arginine Metabolism to Improve Intestinal Barrier Function: A Metabolic Makeover for IBD? [0.03%]
肠道屏障功能的改善：用于治疗IBD的精氨代谢的代谢重塑？
Yevheniya Shevchenko,Michael A Schumacher
Yevheniya Shevchenko
Serotonin, a downstream effector of GLP-2, enhances lacteal contractility and lymph flow [0.03%]
胰高血糖素样肽-2的下游效应物血清素可通过增强乳糜管收缩性促进淋巴流量
Lili Tian,Majid Mufaqam Syed-Abdul,Gary F Lewis
Lili Tian
Glucagon-like peptide-2 (GLP-2) is known to exert some of its biological effects via the release of neurotransmitters, and in view of the absolute requirement for the enteric nervous system (ENS) demonstrated in our recent GLP-2-induced lip...
Colon: A Likely Middleman Connecting the Liver, Adipose Tissue, and Gut Microbiota in MASLD [0.03%]
结肠：在非酒精性脂肪肝病发病机制中连接肝脏、脂肪组织和肠道菌群的中间环节
Medha Priyadarshini,Brian T Layden
Medha Priyadarshini
Role of Long Chain Acyl-CoA Synthetases in MASH-driven Hepatocellular Carcinoma and Ferroptosis [0.03%]
长链酰基辅酶a合成酶在MASH驱动的肝细胞癌及铁死亡中的作用
Peyton Classon,Alexander Q Wixom,Natalia Calixto Mancipe et al.
Peyton Classon et al.
Metabolic-associated steatohepatitis-driven hepatocellular carcinoma (MASH-HCC) incidence is rapidly rising worldwide. Lipid metabolic reprogramming is a hallmark of solid tumors to satisfy cancer high metabolic demand. However, it may conf...
Liquid nutrient drink testing induces gastric myoelectrical abnormalities that correlate with gastroduodenal symptoms [0.03%]
液体营养饮料试验引起胃电活动异常并伴随上腹部症状出现
Hassan Shaaban,Chris Varghese,Gabriel Schamberg et al.
Hassan Shaaban et al.
Chronic gastroduodenal symptoms experienced in functional dyspepsia, chronic nausea and vomiting syndromes, and gastroparesis affect over 10% of the global population and impose a significant healthcare burden. The relationship between aber...