Antibiotics Alter Duodenal Immune Populations Upon Gluten Exposure in Mice: Implications for Non-Coeliac Gluten Sensitivity [0.03%]
抗生素通过改变小鼠十二指肠的免疫细胞群在麸质暴露下的变化对非乳糜泻性麸质敏感性的意义
Jennifer C Pryor,Emily C Hoedt,Wai Sinn Soh et al.
Jennifer C Pryor et al.
A growing proportion of the non-celiac population experience adverse symptoms to gluten. The pathogenesis of non-celiac gluten sensitivity (NCGS) is unclear, but elevated duodenal eosinophils and altered mucosa-associated microbiota (MAM) p...
Intestinal adaptations increase basolateral intestinal glucose uptake and glycolysis in a mouse model of Cystic Fibrosis [0.03%]
肠道适应通过增加基底侧肠葡萄糖吸收和糖酵解来改善囊性纤维化小鼠模型的葡萄糖耐量
Alexander F Lesser,Aura Perez,Chunying Wu et al.
Alexander F Lesser et al.
The gastrointestinal manifestations of Cystic Fibrosis (CF) are a continued source of morbidity and mechanistic uncertainty despite recent advances in CF care. We sought to characterize intestinal glucose demand in a mouse model of CF to be...
FAM134B Controls Collagen I Dynamics in Hepatic Stellate Cell-Driven Fibrosis [0.03%]
FAM134B调控肝星状细胞介导的纤维化中I型胶原动力学
Jagannath Misra,Zachary Hanquier,Reese Baxter et al.
Jagannath Misra et al.
Liver fibrosis is driven by the accumulation of scar tissue in response to injury. Activated hepatic stellate cells (HSCs) secrete fibrogenic proteins that deposit into the extracellular matrix, leading to fibrosis. Increased production of ...
Association between gastric rhythm and gastroesophageal reflux defined by simultaneous body surface gastric mapping and 24-hour pH testing [0.03%]
基于同步体表胃电定位和24小时pH监测的胃食管反流与胃电节律相关性研究
William Xu,Sam Simmonds,Daphne Foong et al.
William Xu et al.
Gastroesophageal reflux disease (GERD) is common and often medically refractory. Abnormal gastric myoelectrical function may contribute to pathogenesis. This prospective observational study with matched controls assessed if myoelectrical ab...
Microbial dysbiosis alters serotonin signaling in a post-inflammatory murine model of visceral pain [0.03%]
肠道微生物失调通过血清素信号通路诱发小鼠腹腔痛觉过敏模型中的疼痛症状
Timothy D Roth,Lillian Russo-Savage,Yasaman Bahojb Habibyan et al.
Timothy D Roth et al.
Serotonin (5-HT) is a multifunctional signaling molecule in the gastrointestinal (GI) tract. 5-HT synthesis is regulated by the gut microbiota. Microbial dysbiosis has been implicated in visceral pain and persistent alterations in gut funct...
Barbora Gromova,Viera Kupcova,Maria Serena Longhi et al.
Barbora Gromova et al.
Sterile inflammation, resulting from hepatocyte death and subsequent release of damage-associated molecular patterns (DAMPs), significantly contributes to liver disease pathogenesis. Neutrophils, as primary responders to liver injury, under...
Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice [0.03%]
烧伤后年老小鼠肠细胞增殖能力下降与衰老增加有关
Travis M Walrath,Mara R Evans,Kenneth Meza Monge et al.
Travis M Walrath et al.
The global population is aging, with one in six people projected to be 65 years or older by 2050. Since people aged 65 and older experience higher rates of morbidity and mortality after burn injury, there is an increased need to develop eff...
Ubiquitin-proteasome pathway activation in the diaphragm of humans with reflux esophagitis [0.03%]
胃食管反流病患者膈肌泛素-蛋白酶体激活损伤大小的对照研究
Suliana Mesquita Paula,Márcia Netto Magalhães Alves,Débora Teles Carvalho da Silva Simões et al.
Suliana Mesquita Paula et al.
Some forms of Gastroesophageal Reflux Disease (GERD) are associated with crural diaphragm (CD) dysfunction, suggesting that GERD may be influenced by skeletal muscle deficiencies. Skeletal muscle atrophy has been strongly linked to alterati...
Mechanisms of liver regeneration and their relevance to steatotic liver disease [0.03%]
肝再生机制及其在脂肪变性肝病中的意义
Gary Huang,V Nathan Subramaniam
Gary Huang