Highly Ca2+-permeable Transient Receptor Potential Vanilloid 6 Contributes to the Protection against Colitis by Regulating Epithelial Barrier Function [0.03%]
高度通透Ca2+的瞬时受体电位香草酸6通过调节上皮屏障功能参与抗结肠炎作用
Yuki Murayama,Hiroyuki Yasuda,Michiko Saito et al.
Yuki Murayama et al.
Transient receptor potential vanilloid 6 (TRPV6) is a highly Ca2+-permeable cation channel predominantly expressed in the intestinal epithelium. It plays a crucial role in maintaining systemic calcium homeostasis by regulating Ca2+ absorpti...
A Pilot, Randomized, Placebo-Controlled Trial of Rimegepant on Visceral Sensation and Symptoms in Non-Constipation IBS Pain [0.03%]
利美加普坦对非便秘型IBS疼痛内脏感觉和症状的影响：一项试点、随机、安慰剂对照试验
Houssam Halawi,Ayah Matar,Iris Wang et al.
Houssam Halawi et al.
Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of rimege...
Late-in-life treadmill-training mitigates gut microbiome imbalances and cardiovascular disease risk in mice [0.03%]
老龄期跑步机训练可缓解小鼠肠道微生物失衡和心血管疾病风险
Jae Min Cho,Seul-Ki Park,Adhini Kuppuswamy Satheesh Babu et al.
Jae Min Cho et al.
Primary aging associates with an imbalanced gut microbiome and cardiovascular disease (CVD) risk in mice and humans. Strong evidence from clinical and pre-clinical studies supports that habitual physical exercise improves cardiovascular fun...
Bolus Pressure and Bolus Mismatch in Patients with Dysphagia and Preserved Esophageal Peristalsis [0.03%]
吞咽功能障碍且食管蠕动保存患者的大块压力及大块失匹配现象研究
Myeongsook Seo,Segyeong Joo,Ravinder K Mittal
Myeongsook Seo
Dysphagia is common in patients with preserved contraction phase of esophageal peristalsis, such as those diagnosed with functional dysphagia (FD) or esophagogastric junction outflow obstruction (EGJOO); amount to ≥ 50% patients undergoing...
Esophageal symptom burden remains high and associates with failed swallows after five years in patients with ineffective esophageal motility [0.03%]
无效食管运动障碍患者的五年随访：较高的食管症状负荷与吞咽失败有关
Andree H Koop,Induja R Nimma,Kevin Avaiya et al.
Andree H Koop et al.
Purpose: Ineffective esophageal motility (IEM) is a motor disorder of the esophagus diagnosed by high-resolution esophageal manometry (HRM) and associated with symptoms of gastroesophageal reflux disease (GERD) and dyspha...
Elucidation of daily timed-palatable meal-anticipatory activity in the circadian system of mice [0.03%]
小鼠昼夜系统中每日定时美味餐食预期活动的阐释
S K Tahajjul Taufique,Averey Eischeid,Isabel Magaña et al.
S K Tahajjul Taufique et al.
Anticipation of daily recurring changes in the environment is critical for survival. When food access is limited to a few hours during the daytime, nocturnal rodents exhibit food-anticipatory activity, which appears a few hours before sched...
Inhibitory effects of somatostatin on glucagon-like peptide-1-mediated acceleration of peristalsis in the rat proximal colon [0.03%]
生长抑素抑制生长抑素类似肽-1加速大鼠近端结肠蠕动的作用
Hiroyuki Nakamori,Fuko Hosoi,Hikaru Hashitani
Hiroyuki Nakamori
Colonic motility is controlled by the enteric nervous system that is modulated by not only autonomic neurotransmitters but substances released from enteroendocrine cells. Glucagon-like peptide-1 (GLP-1) secreted from L cells accelerates per...
Role of interstitial cells of Cajal in regulating tone and responses to enteric motor neurons in the murine pyloric sphincter [0.03%]
Cajal间质细胞在调控小鼠幽门括约肌张力及肠神经元反应中的作用
Ji Yeon Lee,Sang Don Koh,Sal A Baker et al.
Ji Yeon Lee et al.
Gastric slow waves fail to propagate through the pyloric sphincter (PS), thus isolating the specialized motility patterns of the stomach and small intestine. We investigated the role of interstitial cells of Cajal (ICC) in PS of mice. Ca2+ ...
Exploratory Study Characterizing Gastrointestinal Physiological Changes During Controlled Human Hookworm Infection [0.03%]
一种探索性研究：在受控人类钩虫感染过程中胃肠生理变化的特点分析
Thomas C Mules,Mali Camberis,Brittany Lavender et al.
Thomas C Mules et al.
Hookworm infects over 400 million people globally and causes gastrointestinal morbidity, yet its physiological effects remain poorly defined. Controlled human hookworm infection is also being explored as a therapy for gut diseases. We perfo...
Inflammatory pain alters colorectal motility via spinal oxytocinergic pathways [0.03%]
炎症疼痛通过脊髓催产素通路改变结肠运动功能
Tomoya Sawamura,Ayuna Mori,Natsufu Yuki et al.
Tomoya Sawamura et al.
Gastrointestinal motility is regulated primarily by the enteric and the central nervous systems. Our previous studies revealed that central circuits regulating colorectal motility partially overlap with those involved in pain modulation, su...