Hope for the gut: New evidence suggests western diet damage can be undone [0.03%]
肠道的希望：新的证据表明西方饮食造成的伤害可以逆转
Geetha Bhagavatula,Ian M Cartwright
Geetha Bhagavatula
Hypobaric Hypoxia Exposure Impairs Colonic Goblet Cell Subpopulation via the HIF-1α Signaling Pathway [0.03%]
低气压缺氧通过HIF-1α信号通路损伤结肠杯状细胞亚群
Shaojie Zhang,Xiufang Jiang,Wangjingyi Zhang et al.
Shaojie Zhang et al.
Exposure to hypobaric hypoxia during rapid ascent to high altitudes significantly impacts intestinal barrier function. Goblet cells, as one of the primary cell types in the intestinal mucosa, play a crucial role in maintaining this barrier....
Mycobacterium avium subspecies paratuberculosis targets M cells in enteroid-derived monolayers through interactions with β1 integrins [0.03%]
麻风分枝杆菌副结核亚种通过与β1整联蛋白的相互作用靶向肠类器官衍生单层中的M细胞
Grace Baruta,Kyle L Flannigan,Laurie Alston et al.
Grace Baruta et al.
Paratuberculosis is an infectious disease caused by the bacterium, Mycobacterium avium subspecies paratuberculosis (MAP). MAP infection of ruminants triggers progressive wasting disease characterized by granulomatous lymphadenitis, enteriti...
Unique properties of proximal and distal colon reflect distinct motor functions [0.03%]
近端结肠和远端结肠反映不同运动功能的独特特性
Wilmarie Morales-Soto,Kristen Smith-Edwards
Wilmarie Morales-Soto
The gastrointestinal (GI) tract is made up of specialized organs that work in tandem to facilitate digestion. The colon regulates the final steps in this process where complex motor patterns in proximal regions facilitate formation of fecal...
Key Mechanisms in Alcohol-Associated Liver Disease: Hepatic ADH Deficiency, Dysregulated Hepatic Lipid Metabolism and Nonoxidative Ethanol Metabolites [0.03%]
酒精性肝病中的关键机制：肝脏乙醇脱氢酶缺乏，脂质代谢失调和非氧化型乙醇代谢物
Seol Hee Park,Wonhyo Seo
Seol Hee Park
Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling [0.03%]
丁香酸通过激活芳烃受体依赖的AMPK信号来保护与代谢功能障碍相关的脂肪性肝炎
Nikhil Y Patil,Iulia Rus,Felix Ampadu et al.
Nikhil Y Patil et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is an advanced form of metabolic dysfunction-associated steatotic liver disease (MASLD) characterized by accumulation of fats in liver, chronic inflammation, hepatocytic ballooning, an...
The Spatiotemporal Development of Mesenteric Lymphatic Changes in the TNFΔARE/+ Mouse Model of Terminal Ileitis [0.03%]
末端回肠炎TNFΔARE/+小鼠模型中肠系膜淋巴管变化的时空发展过程
Keith Keane,Matthew Stephens,Simon Roizes et al.
Keith Keane et al.
Crohn's disease (CD) is a chronic inflammatory bowel disease which also encompasses significant alterations of the mesenteric lymphatic system. Whether these changes are a mere consequence of, or directly contribute to the inflammation is u...
DIFFERENTIAL RESPONSES TO PROSTAGLANDINS IN THE CIRCULAR AND LONGITUDINAL MUSCLE LAYERS OF THE MURINE ILEUM [0.03%]
小鼠回肠环形肌层和纵向肌层对前列腺素的不同反应
Joong Goo Kwon,Sung Jin Hwang,Elizabeth A H Beckett et al.
Joong Goo Kwon et al.
Prostaglandin E2 (PGE2) actions on intestinal motility are complex due the differential expression of the PGE2 receptors EP1-EP4. We sought to determine the actions of PGE2 on electrical pacemaker and contractile activity of the circular an...
Combination of dietary fiber and exercise training improves fat loss in mice, but does not ameliorate MASLD more than exercise alone [0.03%]
饮食纤维和运动训练的结合可以改善小鼠的脂肪损失，但并不能比单独运动更好地缓解MASLD
Artemiy Kovynev,Mikołaj M Charchuta,Amina Begtašević et al.
Artemiy Kovynev et al.
Background: Lifestyle interventions, such as diet and exercise, are currently the main therapies against metabolic dysfunction-associated steatotic liver disease (MASLD). However, not much is known about the combined impact of fiber and exe...