Spontaneous Ileitis and Post-Surgical Murine Models of Enteric Hyperoxaluria [0.03%]
自发性回肠炎和肠源性高草酸尿小鼠模型术后模型
Karim Jaber,Nadim Zaidan,Melody Ho et al.
Karim Jaber et al.
Enteric hyperoxaluria, a risk factor for kidney stone disease, often arises from malabsorptive bariatric surgeries or inflammatory bowel diseases. Current murine models for studying this condition are limited, necessitating new approaches. ...
Dimethyl Fumarate Attenuates Bile Acid Retention and Liver Fibrosis in a Mouse Model of Cholestasis [0.03%]
富马酸二甲酯通过减少胆汁酸滞留减轻胆汁淤积小鼠模型肝纤维化恶化的作用及机制研究
Hana Lastuvkova,Ester Dohnalkova,Dina Faeq Manna et al.
Hana Lastuvkova et al.
Cholestatic liver diseases are characterized by intrahepatic accumulation of bile acids (BAs), exacerbating liver inflammation, and fibrosis. Dimethyl fumarate (DMF) is a clinically approved antiinflammatory drug that demonstrated protectiv...
Dynamic Functional Luminal Imaging Probe analysis of the anal sphincter opening function during straining in healthy volunteers [0.03%]
健康志愿者在用力时肛门括约肌开放功能的动态功能性腔内影像探针检测
Charlotte Desprez,Anne-Marie Leroi,Guillaume Gourcerol et al.
Charlotte Desprez et al.
Introduction: The objective of the present study was to introduce a novel method assessing anal canal opening in healthy volunteers (HV) using the EndoFLIP™ system. By analyzing dynamic loops during push maneuver, the study aimed to identi...
Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device [0.03%]
一种无线无电池全植入式光学设备及其在自由活动小鼠胃肠道-大脑轴光遗传激活中的应用
Timothy J Hibberd,Andrew Efimov,Yue Wang et al.
Timothy J Hibberd et al.
Considerable evidence suggests the gut-brain axis can influence behaviour. However, there has been a conspicuous lack of technology to provide targeted wireless activation of the gut-brain axis in conscious freely moving animals. We utilise...
Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis [0.03%]
溃疡性结肠炎实验模型中的离子转运和上皮屏障功能障碍
Geoffrey I Sandle,Vazhaikkurich M Rajendran
Geoffrey I Sandle
The global prevalence of ulcerative colitis (UC) and Crohn's disease (CD) is increasing, placing greater burdens on national health systems. The pathophysiology of diarrhea, the commonest debilitating symptom in UC and CD patients, has been...
Metabolic balance of human livers during long-term normothermic machine perfusion [0.03%]
人肝脏长期常温机体内平衡代谢状态的研究
Bianca Lascaris,Linda C Woltjes,Silke Bodewes et al.
Bianca Lascaris et al.
Background & Aims: Normothermic machine perfusion (NMP) is used to preserve and assess the viability of (extended criteria) high-risk donor livers. Long-term NMP (LT-NMP; ≥24h) is emerging as a method to improve or repair livers initially ...
Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice [0.03%]
小鼠巨噬细胞H-铁蛋白的缺失可减轻脂肪性肝炎和肝细胞癌的发展
Yasumasa Ikeda,Masafumi Funamoto,Haruka Itami et al.
Yasumasa Ikeda et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is an increasing global health concern. Approximately one-quarter of patients have non-alcoholic steatohepatitis (NASH), which leads to the development of hepatocellula...
Satomi Kawada,Titi Chotirungsan,Charng-Rong Pan et al.
Satomi Kawada et al.
The swallowing reflex can be induced by peripheral stimulation of the larynx. Although previous studies have suggested that potassium ions exert facilitatory effects on the initiation of swallowing, little information is available on the me...
The effect of corticotropin-release hormone on duodenal permeability and immune activation in healthy volunteers in a double-blind placebo-controlled study [0.03%]
促肾上腺皮质激素释放激素对健康志愿者十二指肠通透性和免疫激活的影响的双盲安慰剂对照研究
Jolien Schol,I-Hsuan Huang,Lukas Balsiger et al.
Jolien Schol et al.
Introduction: In functional dyspepsia, increased gut permeability, low-grade inflammation and altered sensorimotor function have been reported. Both stress and corticotropin-release hormone(CRH) have been shown to increase small bowel perme...