Could physical exercise improve mental health in the context of chronic liver disease? [0.03%]
运动能改善慢性肝病患者的心理健康吗？
Caroline J K Wallace,Marie-Claude Audet
Caroline J K Wallace
ENTERIC GLIA PROMOTES THE SURVIVAL OF CD4 AND CD8 T CELLS IN PLEXITIS: A NEW PLAYER IN CROHN'S DISEASE RECURRENCE? [0.03%]
肠胶质细胞促进克罗恩病神经炎中CD4和CD8T淋巴细胞的存活：克罗恩病复发的新因素？
Catherine Le Berre,Tony Durand,Julie Pabois et al.
Catherine Le Berre et al.
The accumulation of immune cells in and around enteric ganglia, called plexitis, is associated with postoperative recurrence in Crohn's disease. Interaction between T cells and enteric glia is increased at the proximal resection margin in p...
Elucidation of roles of serine/threonine phosphatases PP1 and PP2A in mediating CCK-stimulated growth and enzyme secretion in pancreatic acinar cells [0.03%]
胰泌素刺激的蛋白磷酸酶PP1和PP2A在调节鼠胰腺腺泡细胞生长和酶分泌中的作用研究
Irene Ramos-Alvarez,Robert T Jensen
Irene Ramos-Alvarez
Serine/threonine phosphatases, PP1 and PP2A, play important roles in mediating cellular signaling in different tissues to different stimuli, including glycogen metabolism, protein synthesis/growth and secretion. However, the roles of PP1/PP...
Generation of gastric proton pump atp4a knock-outs in Astyanax mexicanus. A fish model for insights into the mechanisms of acidification by oxynticopeptic cells [0.03%]
Mexican盲鱼转录激活子样效应因子核酸酶技术构建胃壁细胞特异性atp4a基因敲除模型及研究其对酸分泌的影响
Patri Cia G Ferreira,A Wayne Vogl,L Filipe C Castro et al.
Patri Cia G Ferreira et al.
The gastric proton pump H+/K+-ATPase (HKA) is the highly conserved acid secretory mechanism of the gnathostome stomach. HKA is a heterodimeric pump, composed of α and β subunits. In this study we have explored the involvement of this enzy...
Nonyelum Ebigbo,Rhonda F Souza
Nonyelum Ebigbo
Host-microbial interactions within the gastrointestinal tract are increasingly recognized as contributors to health and disease, yet our understanding of these interactions in the esophagus remains limited. Dysbiosis of the esophageal micro...
Liver Bypass in the Development of Pathogen-associated Pulmonary Vascular Disease: Contribution of Mesocaval and Portosystemic Shunts [0.03%]
门体分流在病原体相关肺血管疾病发病机制中的作用：中肝 vein 和门体分流的贡献
Clm Silva,P Puthanveetil,S D Oliveira
Clm Silva
Portosystemic and mesocaval shunts are aberrant vascular connections that bypass hepatic filtration, directly linking the portal to the systemic circulation. These shunts, whether congenital or acquired, play a pivotal role in the pathogene...
Gut Microbiota Dysbiosis in a Novel Mouse Model of Colitis Potentially Increases the Risk of Colorectal Cancer [0.03%]
新的结肠炎小鼠模型中肠道菌群失调可能增加患结直肠癌的风险
Abrory A C Pramana,Guanying Bianca Xu,Siyuan Liang et al.
Abrory A C Pramana et al.
This research investigates the gut microbiota profile in a novel mouse model of colitis with a specific knockout (KO) of the hnRNPI gene in intestinal epithelial cells. While the influence of gut microbiota on colitis pathophysiology in hnR...
Sadhana A Samant,Sanjiv K Hyoju,John C Alverdy et al.
Sadhana A Samant et al.
Inflammatory Bowel Diseases (IBD) mainly involving the disease states of Ulcerative Colitis (UC) and Crohn's disease (CD), are characterized by chronic, relapsing inflammation of the gastrointestinal tract. IBD has an unclear etiology and l...
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon [0.03%]
低聚果糖通过钙感受器和5-HT3受体在近端结肠激活肌间神经元并减慢结肠运动性
Preedajit Wongkrasant,Laurie E Wallace,Wallace K MacNaughton et al.
Preedajit Wongkrasant et al.
Calcium sensing receptors (CaSR) regulate a variety of functions in the gastrointestinal tract. Recently, prebiotic-independent effects of fructooligosaccharides (FOS) on epithelial barrier function were found to be mediated by CaSR. Here w...
Hayley N Templeton,Stuart A Tobet,Luke A Schwerdtfeger
Hayley N Templeton
Parkinson's disease (PD) is a neurodegenerative disorder affecting over 10 million people. A key pathological feature of PD is the accumulation of misfolded α-synuclein (aSyn) protein in the substantia nigra pars compacta (SNpc). Aggregati...