Electroacupuncture via chronically implanted electrodes improves gastrointestinal motility by balancing sympathovagal activities in a rat model of constipation [0.03%]
慢性植入电极电针改善便秘模型大鼠胃肠动力的交感和副交感平衡作用研究
Xinjun Wang,Boli Yang,Jieyun Yin et al.
Xinjun Wang et al.
Electroacupuncture (EA) has been reported for treating constipation in clinical studies. However, little is known of the possible mechanisms involved in the prokinetic effect of EA. The aim of this study was to investigate the effects and u...
Effect of bacterial flagellin on thiamin uptake by human and mouse pancreatic acinar cells: inhibition mediated at the level of transcription of thiamin transporters 1 and 2 [0.03%]
细菌鞭毛素对人和小鼠胰腺外分泌细胞硫胺素吸收的影响：作用于硫胺素转运蛋白1和2转录水平的抑制作用
Padmanabhan Srinivasan,Kasin Yadunandam Anandam,Vignesh Ramesh et al.
Padmanabhan Srinivasan et al.
Thiamin (vitamin B1) is essential for normal cellular metabolism and function. Pancreatic acinar cells (PACs) obtain thiamin from the circulation via a specific carrier-mediated process that involves the plasma membrane thiamin transporters...
Translational and transcriptional responses in human primary hepatocytes under hypoxia [0.03%]
人类原代肝细胞缺氧条件下的转录与翻译反应
Gaya K Hettiarachchi,Upendra K Katneni,Ryan C Hunt et al.
Gaya K Hettiarachchi et al.
The liver is the primary source of a large number of plasma proteins and plays a critical role in multiple biological processes. Inadequate oxygen supply characterizing various clinical settings such as liver transplantation exposes the liv...
Multitranscriptome analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology [0.03%]
多转录组分析揭示了与肝纤维化进展特异性相关的优先基因（独立于病因）
Wei Chen,Xiaoning Wu,Xuzhen Yan et al.
Wei Chen et al.
Elimination or suppression of causative factors can raise the possibility of liver fibrosis regression. However, different injurious stimuli will give fibrosis from somewhat different etiologies, which, in turn, may hamper the discovery of ...
Intrapancreatic fat deposition and visceral fat volume are associated with the presence of diabetes after acute pancreatitis [0.03%]
急性胰腺炎后院内新发糖尿病与腹腔内脂肪沉积及内脏脂肪体积增加有关
Ruma G Singh,Aya Cervantes,Jin Uk Kim et al.
Ruma G Singh et al.
Ectopic fat and abdominal adiposity phenotypes have never been studied holistically in individuals after acute pancreatitis (AP). The aim of the study was to investigate phenotypical differences in ectopic fat and abdominal fat between indi...
Portal milieu and the interplay of multiple antidiabetic effects after gastric bypass surgery [0.03%]
胃旁路术后“通道”微环境与多重降糖效应的交互作用
Atanu Pal,David B Rhoads,Ali Tavakkoli
Atanu Pal
Diabetes is a worldwide health problem. Roux-en-Y gastric bypass (RYGB) leads to rapid resolution of type 2 diabetes (T2D). Decreased hepatic insulin resistance is key, but underlying mechanisms are poorly understood. We hypothesized that c...
Wnt signaling inhibition by monensin results in a period of Hippo pathway activation during intestinal adaptation in zebrafish [0.03%]
环孢素通过抑制Wnt信号通路在斑马鱼肠适应过程中激活Hippo信号通路
Mubina A Isani,Kristin Gee,Kathy Schall et al.
Mubina A Isani et al.
Intestinal adaptation (IA) is a critical response to increase epithelial surface area after intestinal loss. Short bowel syndrome (SBS) may follow massive intestinal resection in human patients, particularly without adequate IA. We previous...
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis [0.03%]
肝肿瘤中的肝CYP1A2活性及术前体积-功能分析的意义
Tilo Wuensch,Niklas Heucke,Jonas Wizenty et al.
Tilo Wuensch et al.
Dynamic liver function assessment by the [13C]methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic cytochrome P-450 (CYP) 1A2 activity. One proven strategy for preoperative risk assessment in liver surgery in...
Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer [0.03%]
全反式维甲酸的抗肿瘤作用及其与吉西他滨的协同作用与胰腺癌中p21激活激酶的下调有关
Kai Wang,Graham S Baldwin,Mehrdad Nikfarjam et al.
Kai Wang et al.
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies worldwide. All-trans retinoic acid (ATRA) has been used as an antistromal agent in PDA, and its antitumor effect has also been reported in various kinds of cancer...
TO901317 inhibits the development of hepatocellular carcinoma by LXRα/Glut1 decreasing glycometabolism [0.03%]
TO901317通过LXRα/Glut1减少糖代谢来抑制肝癌的发展
Ting Xiong,Zihan Li,Xuelong Huang et al.
Ting Xiong et al.
This study was conducted to observe the effect and possible mechanism of TO901317 in vivo and in vitro to provide a new basis for the targeted therapy of hepatocellular carcinoma (HCC). The expressions of liver X receptor (LXR)-α, glucose ...