Transgenic expression of cyclooxygenase-2 in pancreatic acinar cells induces chronic pancreatitis [0.03%]
在胰腺泡皮细胞中表达环氧合酶-2诱导慢性胰腺炎
Haojie Huang,Jiaxiang Chen,Lisi Peng et al.
Haojie Huang et al.
Replacement of the exocrine parenchyma by fibrous tissue is a main characteristic of chronic pancreatitis. Understanding the mechanisms of pancreatic fibrogenesis is critical for the development of preventive and therapeutic interventions. ...
Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds [0.03%]
大鼠肝切片精准模型的分子特征分析及其用于抗纤维化化合物评估的能力研究
Xinqiang Huang,Hong Cai,Ron Ammar et al.
Xinqiang Huang et al.
Precision-cut liver tissue slice (PCLS) contains all major cell types of the liver parenchyma and preserves the original cell-cell and cell-matrix contacts. It represents a promising ex vivo model to study liver fibrosis and test the antifi...
Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds [0.03%]
大鼠肝切片精准模型的分子特征用于抗纤维化化合物评估
Xinqiang Huang,Hong Cai,Ron Ammar et al.
Xinqiang Huang et al.
Precision-cut liver tissue slice (PCLS) contains all major cell types of the liver parenchyma and preserves the original cell-cell and cell-matrix contacts. It represents a promising ex vivo model to study liver fibrosis and test the antifi...
Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes [0.03%]
锌通过在膜上重塑Claudin-2和Claudin-4来改善志贺菌病小肠屏障功能损伤
Paramita Sarkar,Tultul Saha,Irshad Ali Sheikh et al.
Paramita Sarkar et al.
Whether zinc (Zn2+) regulates barrier functions by modulating tight-junction (TJ) proteins when pathogens such as Shigella alter epithelial permeability is still unresolved. We investigated the potential benefits of Zn2+ in restoring impair...
Ziru Li,Shiying Liu,Jianing Lou et al.
Ziru Li et al.
Leucine-rich repeat G protein-coupled receptors (LGRs) and their endogenous ligands R-spondin1-4 (Rspo) are critical in embryonic development and in maintenance of stem cells. The functions of the Rspo-LGR system in differentiated cells rem...
Suthat Liangpunsakul,Naga Chalasani
Suthat Liangpunsakul
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of histopathological phenotypes ranging from simple steatosis to more severe liver disease associated with cell injury, including nonalcoholic steatohepatitis (NASH), advanced fi...
Absence of the sulfate transporter SAT-1 has no impact on oxalate handling by mouse intestine and does not cause hyperoxaluria or hyperoxalemia [0.03%]
硫酸盐转运蛋白SAT-1的缺失不影响小鼠肠道处理草酸的能力，不会导致高草酸尿症或高草酸血症
Jonathan M Whittamore,Christine E Stephens,Marguerite Hatch
Jonathan M Whittamore
The anion exchanger SAT-1 [sulfate anion transporter 1 (Slc26a1)] is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain undetermined. Previously, characterization o...
Acute administration of IL-6 improves indices of hepatic glucose and insulin homeostasis in lean and obese mice [0.03%]
急性注射IL-6可改善瘦小和肥胖小鼠的肝脏葡萄糖和胰岛素稳态指标
Willem T Peppler,Logan K Townsend,Grace M Meers et al.
Willem T Peppler et al.
Obesity can lead to impairments in hepatic glucose and insulin homeostasis, and although exercise is an effective treatment, the molecular targets remain incompletely understood. As IL-6 is an exercise-inducible cytokine, we aimed to identi...
Asymmetric cell division-dominant neutral drift model for normal intestinal stem cell homeostasis [0.03%]
不对称细胞分裂-优胜漂变模型解释正常肠干细胞稳态
Yoshitatsu Sei,Jianying Feng,Carson C Chow et al.
Yoshitatsu Sei et al.
The normal intestinal epithelium is continuously regenerated at a rapid rate from actively cycling Lgr5-expressing intestinal stem cells (ISCs) that reside at the crypt base. Recent mathematical modeling based on several lineage-tracing stu...
5-HT3 receptor signaling in serotonin transporter-knockout rats: a female sex-specific animal model of visceral hypersensitivity [0.03%]
五羟色胺转运体敲除大鼠中的5-ht3受体信号传导：一种女性特异性腹腔高敏感性动物模型
Nadine El-Ayache,James J Galligan
Nadine El-Ayache
The irritable bowel syndrome (IBS) is a functional gastrointestinal motor and visceral sensation disorder that is more common in women than men. Female serotonin transporter (SERT)-gene knockout (KO) rats exhibit hypersensitivity to colorec...