Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing [0.03%]
聚胺通过调节肠道上皮更新和伤口愈合所需的关键线粒体代谢发挥功能
Cassandra A Cairns,Ting Chen,Naomi Han et al.
Cassandra A Cairns et al.
Homeostasis of the mammalian intestinal epithelium is tightly regulated by multiple factors including cellular polyamines, but the exact mechanism underlying polyamines in this process remains largely unknown. Mitochondria are the powerhous...
Mouse Models of Eosinophilic Esophagitis: Molecular and Translational Insights [0.03%]
小鼠模型在嗜酸性食管炎分子及转化研究中的应用
Jazmyne L Jackson,Abigail J Staub,Annie D Fuller et al.
Jazmyne L Jackson et al.
Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus that exerts a significant clinical and financial burden in developed countries. Despite an emerging interest in this disease, the cellular and molecu...
Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in Mdr2 KO mice [0.03%]
甘氨酰-β-茋基甲酰胺通过调节胆汁酸代谢减少Mdr2基因敲除小鼠肝胆损伤
Mohammad Nazmul Hasan,Huaiwen Wang,Wenyi Luo et al.
Mohammad Nazmul Hasan et al.
Cholestasis results from impaired bile flow that causes hepatic bile acid accumulation and injury. Alleviating bile acid hepatobiliary toxicity is a major therapeutic goal in cholestasis. Our recent study revealed a potent anti-cholestasis ...
Lacticaseibacillus rhamnosus GG- Driven Remodeling of Arginine Metabolism Mitigates Gut Barrier Dysfunction [0.03%]
鼠李糖乳杆菌GG通过重构精氨酸代谢缓解肠道屏障功能障碍
Jayson M Antonio,Yue Liu,Panan Suntornsaratoon et al.
Jayson M Antonio et al.
Inflammatory bowel diseases (IBD) and gut barrier impairment are associated with changes in dietary tryptophan and arginine metabolism, but mechanisms of barrier perturbation and restoration are unclear. We show here that the widely consume...
Gut-Heart Axis: Cardiac Remodeling and Heart Failure in the Context of Inflammatory Bowel Disease and Dysbiosis [0.03%]
肠心轴的作用：炎症性肠病和肠道菌群失调下的心脏重塑与心力衰竭
Thierry Kochkarian,Hania I Nagy,Qingjie Li
Thierry Kochkarian
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are debilitating and complex chronic gastrointestinal disorders that affect not only the gut but also extraintestinal organs, including the heart. The gut-...
Biomarkers of Intestinal Permeability are Linked to Incident Cardiovascular Diseases and Cardiovascular Events: A Review of Prospective Studies [0.03%]
肠道通透性生物标志物与心血管疾病发病率和事件的关系：前瞻性研究的综述
Alexis R Quirk,Jenna K Schifferer,Katherine A Maki et al.
Alexis R Quirk et al.
Intestinal hyperpermeability, which refers to translocation of microbial factors into the bloodstream, is associated with many chronic diseases. Increased intestinal permeability may contribute to the pathophysiology of these diseases by pr...
Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease [0.03%]
菌群移位与代谢功能障碍相关脂肪肝病的肠- adipose-liver轴
Daria Igudesman,Gongxin Yu,Charlene Dauriat et al.
Daria Igudesman et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects ~40% of adults, but causal mechanisms remain elusive. Preclinical models implicate the gut microbiota in MASLD pathogenesis, yet transla...
Jasmine J Park,Giovanni Tagliabue,Michael Ji et al.
Jasmine J Park et al.
Background: Together the costal and crural diaphragm constitute the primary respiratory muscle in mammals, but functionally they are distinct. The crural segment has additional gastrointestinal function, wrapped around the esophagus at the ...
ASBT governs neonatal bile acid homeostasis early in life despite its strong ileal repression [0.03%]
ASBT调控生后的胆汁酸稳态早期尽管它受到强烈的回肠抑制
Joyce Morales Aparicio,Zhengzheng Hu,Amy M Peiper et al.
Joyce Morales Aparicio et al.
Neonatal bile acid metabolism is distinct from that of adults due to developmental regulation of key transporters and enzymes. The apical sodium-dependent bile acid transporter (ASBT) is transiently repressed in the intestine after birth, y...