Flavor chemicals in vaping products induce pulmonary dendritic cell maturation [0.03%]
调味电子烟产品引起肺树突状细胞成熟
Félix Tremblay,Judith Fortier,Marie Pineault et al.
Félix Tremblay et al.
Vaping products contain numerous flavor chemicals that are known immunological sensitizers associated with the elicitation of immune-mediated hypersensitivity responses. Therefore, we investigated the immune response associated with sensiti...
Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis [0.03%]
琥珀酸通过琥珀酸/SUCNR1轴加重肺纤维化
Rishi Rajesh,Agnes Anna Mooslechner,Hannah Schweighofer et al.
Rishi Rajesh et al.
Introduction: Idiopathic pulmonary fibrosis(IPF) is a chronic progressive lung disease that leads to destruction of alveoli and replacement by fibrotic tissue. Metabolic profiling of lung tissue and serum from IPF patient...
Development of a preclinical model of ICU associated sleep fragmentation and effects on pneumonia recovery in mice [0.03%]
ICU相关睡眠片段化的临床前小鼠模型的建立及其对肺炎恢复的影响研究
Mahendra Damarla,Karthik Suresh,Linda Zheng et al.
Mahendra Damarla et al.
Patients in the intensive care unit (ICU) experience many ICU-specific factors that could impact their outcomes apart from their underlying acute illness. The precise function of sleep is not clear but its importance is suggested from liter...
Intraamniotic Vitamin D Preserves Lung Development and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia due to Intraamniotic sFlt-1 [0.03%]
胎内维生素D保存肺部发育并防止由于胎内可溶性flt-1引起的实验支气管肺发育不良的肺动脉高压
Michael W Cookson,Tania Gonzalez,Elisa M Bye et al.
Michael W Cookson et al.
Preterm infants born to mothers with preeclampsia, a disease of vascular dysfunction, are at increased risk for bronchopulmonary dysplasia (BPD). Endothelial cells are critical in both maintaining proper vascular function and coordinating l...
TrkB Signaling Promotes Alveolar Capillary Angiogenesis Following Perinatal Hyperoxic Damage [0.03%]
TrkB信号转导促进围产期高氧损伤后肺泡毛细血管的生成
Qing Ma,Hanxiang Liu,Ming Liu et al.
Qing Ma et al.
Impaired angiogenesis characterized by the reduced proliferation of pulmonary endothelial cells leads to reduced capillary density in patients with bronchopulmonary dysplasia (BPD). In a mouse model of BPD, perinatal hyperoxic injury decrea...
Pulmonary capillary blood volume and diffusing membrane capacity during exercise in humans: role of pulmonary artery pressure [0.03%]
运动过程中人的肺毛细血管血容量和扩散膜能力：肺动脉压力的作用
Andrew W D&#x;Souza,Andrew R Brotto,Bronwen Hicks et al.
Andrew W D&#x;Souza et al.
During exercise, lung diffusing capacity for carbon monoxide (DLCO), pulmonary capillary blood volume (Vc), and diffusing membrane capacity (DM) increase secondary to a rise in pulmonary artery pressure (PAP) and central blood volume mobili...
Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi [0.03%]
过敏性气道炎症放大豚鼠叶间支气管的肥大细胞反应
Mu Nie,Jielu Liu,Yujiao Xiang et al.
Mu Nie et al.
Excessive uncontrolled airway narrowing is the main cause of the symptoms in asthma, yet the reasons behind this problem are still elusive. As mechanistic studies of isolated airways from asthmatic individuals are almost impossible to perfo...
The cystathionine-γ-lyase inhibitor DL-propargylglycine augments the ability of L-cysteine ethyl ester to overcome the adverse effects of morphine on breathing [0.03%]
胱硫醚-γ-裂解酶抑制剂DL-丙炔甘氨酸增强L-半胱氨酸乙酯克服吗啡对呼吸的不良影响的能力
Paulina M Getsy,Gregory A Coffee,Santhosh M Baby et al.
Paulina M Getsy et al.
L-cysteine ethyl ester (L-CYSee) overcomes adverse effects elicited by systemic injection of morphine on ventilatory parameters and arterial blood-gas chemistry in rats. L-CYSee or L-cysteine, resulting from the de-esterification of L-CYSee...
Therapeutic strategies to reverse cigarette smoke-induced ion channel and mucociliary dysfunction in COPD airway epithelial cells [0.03%]
用于逆转慢性阻塞性肺病气道上皮细胞中香烟烟雾诱导的离子通道和黏液纤毛功能障碍的治疗策略
Neerupma Silswal,Nathalie Baumlin,Steven Haworth et al.
Neerupma Silswal et al.
Cigarette smoke (CS) is a leading cause of chronic obstructive pulmonary disease (COPD). Here, we investigated whether the ion channel amplifier nesolicaftor rescues CS-induced mucociliary and ion channel dysfunction. Since CS increases exp...
The Impact of Electronic Cigarettes on Airway Epithelial Barrier Integrity in Preclinical Mouse Model [0.03%]
电子烟对临床前小鼠模型气道上皮屏障完整性的影响
Amelia L Beaumont,Andjela Raduka,Nannan Gao et al.
Amelia L Beaumont et al.
The increasing use of electronic cigarettes (e-cigs) among adolescents poses significant public health risks. This study investigates the impact of e-cigs on the airway epithelial barrier, focusing on apical junctional complexes (AJCs), inc...