Untangling the nets - a roadmap to standardized sampling and analysis of exhaled volatile organic compounds powered by in silico medicine [0.03%]
解开迷雾：基于模拟医学的呼出挥发性有机化合物标准化采样和分析路线图
Robin Curnow,Carl A Whitfield,Waqar Ahmed et al.
Robin Curnow et al.
Biomarkers based on volatile organic compounds (VOCs) measured in human breath have been investigated in a wide range of diseases. However, the excitement surrounding such biomarkers has not yet translated to the discovery of any that are r...
Mesenchymal Stromal Cell Extracellular Vesicles Reduce Pseudomonas Biofilm Formation, and let-7b-5p Loading Confers Additional Anti-Inflammatory Effects [0.03%]
间充质基质细胞外泌体可减少铜绿假单胞菌生物膜形成并加载let-7b-5p可提供额外的抗炎作用
Sharanya Sarkar,Roxanna Barnaby,Amanda B Nymon et al.
Sharanya Sarkar et al.
Cystic Fibrosis (CF) is a multiorgan disease caused by mutations in the CFTR gene, leading to chronic pulmonary infections and hyperinflammation. Among pathogens colonizing the CF lung, Pseudomonas aeruginosa is predominant, infecting over ...
TGFβ induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K [0.03%]
转化生长因子β通过PI3K诱导囊性纤维化患者肺部过度分泌白细胞介素-6
Grace Scharf,Cynthia R Davidson,Vladimir Ustiyan et al.
Grace Scharf et al.
Cystic Fibrosis (CF) is characterized by impaired mucociliary clearance and pulmonary infections. Accumulating evidence suggests that fundamentally abnormal inflammatory responses also contribute to CF pathology. TGFβ, a pleiotropic cytoki...
Mrinmay Chakrabarti,Mollie Phillips,Rana Dhar et al.
Mrinmay Chakrabarti et al.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are inflammatory conditions with substantial rates of morbidity and mortality, but no effective treatments. The lack of effective treatments and unacceptably high mortality ...
Mechanisms of Lung Crosstalk with End-Organs: Scientific Session V: ReSPIRE 2025 [0.03%]
肺与器官之间的交叉对话机制：科学研讨会V：ReSPIRE 2025
Navneet Singh,Ceren Koçana,Eric P Schmidt et al.
Navneet Singh et al.
Session V of the inaugural biennual Research Symposium on Pulmonary Injury and Repair of the Endothelium (ReSPIRE) showcased cutting-edge research on pulmonary endothelial crosstalk with end-organs and its role in vascular disease. Growing ...
p53-miR-34a Feedback in Lung Fibroblasts Regulates Antifibrotic Effects of CSP7, Nintedanib and Pirfenidone [0.03%]
CSP7、尼替尼和吡非尼酮的抗纤维化作用受肺成纤维细胞中的p53-miR-34a反馈调节
Liang Fan,Rashmi S Shetty,Huy Minh Dao et al.
Liang Fan et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by progressive and irreversible loss of lung function. CSP7 exerts anti-fibrotic effects on fibrotic lung (myo)fibroblasts, which are the primary effector cells in progres...
The impact of hyperoxia and antibiotics on lung mesenchymal cells in experimental bronchopulmonary dysplasia [0.03%]
hyperoxia和抗生素对实验性支气管肺发育不良中肺间充质细胞的影响
Cathy van Horik,Joel Anne Meyboom,Anne Boerema-de Munck et al.
Cathy van Horik et al.
Bronchopulmonary dysplasia (BPD) is the most common adverse outcome in preterm neonates, and a high risk for early-onset emphysema and asthma. BPD is characterized by disrupted alveolar and microvascular development, due to a variety of pat...
Effect of elexacaftor and bamocaftor on the metabolic and thermal stability of the F508del-CFTR protein in human airway epithelial cells [0.03%]
新型CFTR矫正剂艾瑞可沙弗和班莫沙弗对人支气管上皮细胞系中F508del-CFTR蛋白代谢及热稳定性的影响研究
Thomas Carrez,Sandra Mirval,Christine Barrault et al.
Thomas Carrez et al.
Trikafta (elexacaftor/tezacaftor/ivacaftor, ETI) is approved for cystic fibrosis (CF) patients with at least one F508del mutation in the CFTR gene or another responsive mutation based on in vitro data. However, the pharmacological effects o...
Bioenergetics and Metabolism of the Pulmonary Endothelium: Scientific Session I, ReSPIRE 2025 [0.03%]
肺内皮细胞的生物能学和代谢：ReSPIRE 2025会议第一科学 session
Reece P Stevens,Justin T Roberts,Wolfgang M Kuebler et al.
Reece P Stevens et al.
Session I of the inaugural biennial Research Symposium on Pulmonary Injury and Repair of the Endothelium (ReSPIRE) highlighted recent advances in endothelial bioenergetics and metabolism and their role in pulmonary vascular diseases. Emergi...