Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension [0.03%]
肾上腺髓质素过表达保护小鼠免受实验性支气管肺发育不良及其相关肺动脉高压的影响
Shyam Thapa,Poonam Sarkar,M Waleed Gaber et al.
Shyam Thapa et al.
Bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) or BPD-PH is a lung disease of infants with significant morbidity. Adrenomedullin (Adm) is an angiogenic peptide that signals through calcitonin receptor-like receptor ...
From Development to Regeneration: The Endothelial Interface in Lung Injury and Repair [0.03%]
从发育到再生：肺损伤和修复过程中的内皮界面作用
Lisandra Vila Ellis,David N Cornfield,Michael P Croglio et al.
Lisandra Vila Ellis et al.
The pulmonary alveolar-capillary niche is a highly specialized interface that balances gas exchange with maintenance functions and repair. Advances in single cell transcriptomics have uncovered endothelial heterogeneity which underlies deve...
Early life oxidant pollutant exposure induces lung redox and RAAS dysregulation: Implications for innate immune responses [0.03%]
早期氧化污染物暴露诱导肺部氧化还原和RAAS失调：对固有免疫反应的影响
Janice A Dye,Helen H Nguyen,Erica J Stewart et al.
Janice A Dye et al.
The potential for early life air pollutant exposure to result in later onset respiratory disease in children and adults is an emerging public health concern. Fetal-growth-restriction (FGR) and childhood res-piratory infections are associate...
Dietary Influence on Lung Injury and Immune Modulation in Cadmium-Exposed Mice [0.03%]
膳食对镉暴露小鼠肺损伤及免疫调控的影响研究
Chandrashekhar Prasad,Debolina Dasgupta,Aprajita Tripathi et al.
Chandrashekhar Prasad et al.
Cadmium (Cd), a toxic heavy metal found in air pollution, poses serious risks to lung health due to its efficient pulmonary absorption and prolonged biological half-life. This study examines how ad-libitum (AL), time-restricted feeding (TRF...
SEX MODULATES THE VENTILATORY RESPONSE TO PASSIVE LIMB-INDUCED MUSCLE MECHANORECEPTOR ACTIVATION DURING HYPOXIA IN HUMANS [0.03%]
性别对人类低氧条件下被动肢体运动肌肉机械感受器激活的通气反应的影响
Diogo Machado Oliveira,Talita M Silva,Tamires S Cesar et al.
Diogo Machado Oliveira et al.
Sex appears to modulate interactions between neural mechanisms involved in regulating pulmonary ventilation during mild hypoxic exercise. Therefore, we compared pulmonary ventilation responses elicited by isolated and combined stimulation o...
Computer model-based injury prediction and evaluation of lung function in mice with acute and ventilator-induced lung injuries [0.03%]
基于计算机模型的急性肺损伤和机械通气所致肺损伤的小鼠伤情预测及肺功能评估
Elizabeth Kaye,Alexander Sosa,Katharine Drayton Warner et al.
Elizabeth Kaye et al.
Invasive mechanical ventilation is a lifesaving intervention for acute respiratory distress syndrome (ARDS) patients but also causes ventilator-induced lung injury (VILI) that can be challenging to avoid due to inter-patient and temporal he...
Scar Wars: The Viral Menace [0.03%]
伤疤大战：病毒威胁
Sara Kass-Gergi,Nicolas P Holcomb,Michael M Maiden et al.
Sara Kass-Gergi et al.
Pulmonary fibrosis (PF) is a severe consequence of respiratory infections, characterized by excessive extracellular matrix deposition and irreversible lung architectural damage. Once considered a rare condition, PF is now increasingly recog...
Sorted-Cell Proteomics Reveals an AT1-Associated Epithelial Cornification Phenotype and Suggests Endothelial Redox Imbalance in Human Bronchopulmonary Dysplasia [0.03%]
有序单元蛋白质组学揭示了人支气管肺发育不全中AT1相关上皮角化表型并提示内皮氧化还原不平衡
Mereena George Ushakumary,William B Chrisler,Gautam Bandyopadhyay et al.
Mereena George Ushakumary et al.
Bronchopulmonary dysplasia (BPD) is a neonatal lung disease characterized by inflammation and scarring leading to long-term tissue damage. Previous whole tissue proteomics identified BPD-specific proteome changes and cell type shifts. Littl...
Aerosolized Vitamin D Attenuates Ozone-Induced Inflammation and Transcriptional Responses Via Membrane Antioxidant Effects in Human Bronchial Epithelial Cells [0.03%]
雾化维生素D通过细胞膜抗氧化作用缓解臭氧诱导的人支气管上皮细胞炎症和转录反应
Kevin D Schichlein,Syed Masood,Hye-Young H Kim et al.
Kevin D Schichlein et al.
Ozone exposure increases the risk of infection, worsens lung diseases, and causes systemic health issues. As ambient ozone levels continue to rise globally, effective interventions are needed to reduce these harmful effects. Vitamin D, know...
Airway sympathectomy attenuates inflammation, transcriptional ratios of Muc5ac and Muc5b, and airway mechanic deficits in mice delivered intranasal IL-13 [0.03%]
鼻交感神经切断术可减轻小鼠IL-13诱导的气道炎症、Muc5ac和Muc5b转录比失衡及机械功能障碍
Pedro Trevizan-Baú,Amy L Fagan,Shanil P Amin et al.
Pedro Trevizan-Baú et al.
Excessive mucus in the airways is an underlying pathological feature of many airway diseases, including asthma. Therapeutic options to reduce mucus production in the airways remain limited. One possible therapeutic target is the airway symp...