Chemogenetic inhibition of the carotid bodies blunts hind-limb suspension microgravity-induced muscle alterations in rats [0.03%]
化学遗传抑制颈动脉体削弱rats失重性后肢悬吊引起的肌肉改变
David C Andrade,Camila Salazar-Ardiles,Camilo Toledo et al.
David C Andrade et al.
Microgravity is known to promote muscle loss and impair physical performance. The carotid bodies (CB) chemoreceptors are sensitive to several stimuli and have been associated with peripheral vascular control and deterioration in exercise pe...
Carolyn Damilola Ekpruke,Patricia Silveyra
Carolyn Damilola Ekpruke
Lung diseases are major global causes of morbidity and mortality, yet the molecular basis of their observed sex differences remains unclear. Beyond their roles in reproductive biology, estrogens are central regulators of pulmonary homeostas...
Pedro F Spiller,Mateus R Amorim,Vsevolod Y Polotsky
Pedro F Spiller
Interest in respiratory stimulants has increased over the years. Research have intensified after the introduction of opioids that cause respiratory depression. In the most recent years, the indiscriminate consumption of opioids has generate...
Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency [0.03%]
G6PD缺乏加剧博来霉素诱导的肺纤维化和功能障碍
Christina Signoretti,Samuel Fatehi,Rhonda Drewes et al.
Christina Signoretti et al.
Pulmonary fibrosis (PF) is a major cause of morbidity and mortality. Although increased oxidative stress and altered metabolism are implicated in PF pathobiology, our knowledge regarding the contribution of the glucose metabolism to the syn...
Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells [0.03%]
定量蛋白组学揭示了高氧暴露下肺泡上皮细胞内线粒体功能障碍导致的代谢变化及表型转换缺陷之间的联系
Abhrajit Ganguly,Cynthia Carter,Aristides Rivera Negron et al.
Abhrajit Ganguly et al.
Newborn infants especially those born preterm often require supplemental oxygen therapy, however, exposure to supraphysiological oxygen (hyperoxia) can disrupt normal lung development and contribute to neonatal lung injury, including bronch...
Novel Ultrastructural Insights in Lung Surfactant Membrane Complexes under Closer-to-Native Conditions as Revealed by Cryo-Microscopy Techniques [0.03%]
应用冷冻显微镜技术从更接近天然状态下获得肺表面活性剂膜复合物的全新超结构见解
Francisco Javier Chichón,Alejandro Cerrada,Rocío Arranz et al.
Francisco Javier Chichón et al.
Lung surfactant (LS) plays an essential role in preventing lung collapse due to physical forces by forming surface-active lipid-protein membranous films at the respiratory air-liquid interface. Throughout its biological cycle, LS exists in ...
Predominant lung cDC2 phenotype in cigarette smoke-exposed mice favors polarization of IL-17-producing CD4+ T cells [0.03%]
小鼠香烟烟雾暴露主要使肺cDC2表型偏向产生IL-17的CD4+T细胞极化
Dawit T Mengistu,Mariam S Toma,Benjamin C Anderson et al.
Dawit T Mengistu et al.
Chronic obstructive pulmonary disease (COPD) is characterized by a deficiency within the lungs of regulatory T cells (Tregs) and an excess of Th17 cells, termed T17/Treg imbalance. Conventional dendritic cells type-1 (cDC1) and type-2 (cDC2...
Particulate Matter Increases Bone Morphogenetic Protein 2 in Lung Fibroblasts [0.03%]
颗粒物通过增加肺成纤维细胞骨形态发生蛋白2的表达促进肌成纤维细胞分化
Nathan Craig,Jack Paul Berens,Eistine Boateng et al.
Nathan Craig et al.
Particulate matter less than 2.5 μm (PM2.5) contributes to many chronic respiratory disorders, but the mechanisms for this are not fully understood. The actions of PM2.5 on lung epithelial cells have been well studied, but their effect on ...
Roger Ming Li,Maike Stentenbach,Dino Bee Aik Tan et al.
Roger Ming Li et al.
Idiopathic pulmonary fibrosis (IPF) is a serious respiratory disease with a poor prognosis and limited treatments. IPF is characterised by accumulation of extracellular matrix, destruction of gas exchange units and decline in lung function....
Role of the Two-Pore-Domain Potassium channel TREK-1 (K2P2.1) in Hyperoxia- and Mechanical Stretch-Induced Alveolar Epithelial Injury [0.03%]
两孔钾通道TREK-1(K2P2.1)在氧中毒和机械牵张所致肺泡上皮细胞损伤中的作用
Nairrita Majumder,Benjamin Lopez,Aren Kasparian et al.
Nairrita Majumder et al.
Hyperoxia (HO) and mechanical ventilation (MV) are the mainstay of treatment for patients with acute respiratory failure, but both interventions can also accelerate further lung injury, highlighting the need for better therapeutic approache...