Receptor agonist of NFκB signaling ligand directs lung epithelial cell expansion through RANK signaling [0.03%]
NFκB信号配体受体激动剂通过RANK信号促进肺上皮细胞增殖
Habibie Habibie,Jelmer R Vlasma,Kurnia Sari Setio Putri et al.
Habibie Habibie et al.
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, with progressive emphysema driven by repeated epithelial damage and impaired repair. Recently, we found that secretion of cytokine rece...
cAMP-enriched extracellular vesicles improve outcomes in pulmonary hypertension [0.03%]
富含cAMP的细胞外囊泡可改善肺动脉高压的预后
Aritra Bhadra,Frederic Bonnie,Jenny Hewes et al.
Aritra Bhadra et al.
Extracellular vesicles (EVs) containing cyclic adenosine monophosphate (cAMP-EVs) activate signaling based on protein kinase A in recipient endothelial cells, but limited information is available about the function of cAMP-EVs under physiol...
Mitochondrial-Derived Microproteins in Lung Disease: Insights and Implications [0.03%]
线粒体来源的微肽在肺疾病中的作用：见解与意义
Molly Behan,Kelvin Yen,Pinchas Cohen et al.
Molly Behan et al.
As bioactive microproteins, Mitochondrial-Derived-MicroProteins (MDPs) are encoded within the small open reading frames (sORFs) of mitochondrial DNA. MDPs have been shown to be altered in a number of disease states and have mitochondrial, n...
Early Detection of Small Airway Dysfunction in Smokers and People with COPD via Forced Oscillation Technique and its Association with Biomarkers: a Pilot Study [0.03%]
基于强迫振荡技术的小气道功能障碍早期检测及其与生物标志物相关性的研究：一项初步研究
Prem Bhattarai,Maksim Grigorenko,Wenying Lu et al.
Prem Bhattarai et al.
Background: Early airflow changes associated with tobacco smoking often occur without observable obstruction or symptoms. Spirometry, the gold standard, has limitations in detecting early disease highlighting the need for sensitive diagnost...
Genetic and chemical correction of cystic fibrosis reduces airway susceptibility to SARS-CoV-2 [0.03%]
遗传和化学纠正囊性纤维化降低气道对SARS-CoV-2的易感性
Stuart D Rollins,Adam J Hume,Da-Yuan Chen et al.
Stuart D Rollins et al.
The airway epithelium, a primary target for viral infection, plays a critical role in disease response-particularly in individuals with pre-existing airway conditions such as cystic fibrosis (CF). At the onset of the SARS-CoV-2 pandemic, CF...
Development of a Novel Potential Difference Probe with Bedside Validation Simulator for Potential Difference Testing [0.03%]
一种新型电位差探针的开发及其床旁验证模拟器的研制用于电位差检测
David O Otuya,Kadambari Vijaykumar,Justin Anderson et al.
David O Otuya et al.
Cystic fibrosis (CF) is caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to abnormal anion transport and consequent airway dehydration and hyper-viscous mucus. Pote...
Brepocitinib, a selective TYK2/JAK1 inhibitor, mitigates neutrophilic inflammation and glucocorticoid receptor-β expression in COPD [0.03%]
一种选择性的TYK2/JAK1抑制剂布罗西替尼可缓解慢性阻塞性肺疾病中的中性粒细胞炎症和糖皮质激素受体-β表达
Barsha Baisakhi Nayak,Thomas Bärnthaler,Rishi Rajesh et al.
Barsha Baisakhi Nayak et al.
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by neutrophil-dominant, corticosteroid-refractory airway inflammation involving the IL-23/IL-17A axis. IL-23 primarily activates the Janus kina...
Tumor Necrosis Factor α-Induced Endoplasmic Reticulum Stress Promotes Airway Smooth Muscle Cell Proliferation [0.03%]
肿瘤坏死因子α诱导的内质网应激促进气道平滑肌细胞增殖
Debanjali Dasgupta,Gary C Sieck
Debanjali Dasgupta
Pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα) induce airway smooth muscle (ASM) cell proliferation. Previously we showed that TNFα induces an endoplasmic reticulum (ER) stress response involving autophosphorylation...
Single-cell transcriptomics reveal alveolar macrophages-specific responses in single-hit ozone exposure model in mice [0.03%]
单细胞转录组揭示了小鼠一次接触臭氧暴露模型中肺泡巨噬细胞的特异性反应
Thao Vo,Ishita Choudhary,Sonika Patial et al.
Thao Vo et al.
Alveolar macrophages (AMs), a highly plastic immune cell population, are among the first responders to inhaled ozone (O3) and its ozonated products in the lung airspaces. However, the comprehensive understanding of how AMs respond to O3, pa...
PLK1 Inhibition by Volasertib Suppresses Key Transcriptional Regulators Underlying Fibroblast Activation and Pulmonary Fibrosis [0.03%]
PLK1抑制剂Volasertib通过抑制成纤维细胞活化及其在肺纤维化中关键转录因子的表达而发挥抗肺纤维化作用
Priyanka Singh,Pradeep Kumar Patel,Rajesh K Kasam et al.
Priyanka Singh et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease marked by aberrant fibroblast activation, resulting in excessive proliferation, survival, and accumulation of extracellular matrix (ECM). A critical ba...