MicroRNA-Enriched EVs from mesenchymal stromal cells: a novel approach to suppress biofilm and inflammation in CF airway epithelium [0.03%]
富含microRNA的间质基质细胞源EVs：一种抑制囊性纤维化气道上皮生物被膜和炎症的新方法
Anushka Raghubansi,Catherine M Greene
Anushka Raghubansi
Obese Adipocytes Induce Fibroblast-to-Myofibroblast Transition through TGF-β1 signaling: Implications in Asthma Pathogenesis [0.03%]
肥胖脂肪细胞通过TGF-β1信号通路诱导成纤维细胞向肌成纤维细胞转化：在哮喘发病机制中的意义
Nour Jalaleddine,Mahmood Hachim,Alexander Giddey et al.
Nour Jalaleddine et al.
Obesity, a key risk factor for severe asthma, is associated with worsening symptoms and poor responses to conventional therapies. Recent studies have highlighted the presence of adipocytes within airway walls, which correlates positively wi...
Coal dust complexes host cell iron to impact metal homeostasis and pneumoconiosis [0.03%]
煤尘复合物通过影响金属稳态和尘肺病来储存细胞铁
Andy J Ghio,Joleen M Soukup,Lisa A Dailey et al.
Andy J Ghio et al.
Surface complexation of cell iron following particle exposure can be relevant to coal mine dust lung disease. We tested the postulate that 1) coal dust and humic substances (HS), a specific component of coal, complex intracellular iron from...
Ovarian Hormones and Obesity Drive Th17-mediated Airway Inflammation through Estrogen Receptor-α Signaling [0.03%]
雌激素受体-α信号通过卵巢激素和肥胖促进Th17介导的气道炎症
Emely Henriquez Pilier,Jacqueline-Yvonne Cephus,Shelby N Kuehnle et al.
Emely Henriquez Pilier et al.
Obesity is a risk factor for increased prevalence and severity of asthma, particularly in females. As adults, females have increased prevalence of asthma compared to males. Yet, the mechanisms remain unclear on how sex hormones and obesity ...
Single cell microfluidic quantification of miRNA-21 and miRNA-34a reveals miRNA interactions in small airway epithelial cells and fibroblasts from COPD patients [0.03%]
单细胞微流体量化COPD患者小气道上皮细胞和成纤维细胞中的miRNA-21和miRNA-34a以揭示其相互作用
Vanessa Ho,Jonathan R Baker,Peter S Fenwick et al.
Vanessa Ho et al.
Rationale: MicroRNA-21 and microRNA-34a are implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, but their cell-specific expression patterns and interactions within individual airway cells remain unexplored. Objective: T...
Optimized primary organotypic culture from murine neonatal tracheal airway epithelial cells [0.03%]
来自小鼠气管上皮细胞的优化主要组织培养类型文化
Yan Han,Rewa Kulkarni,Stephan Pribitzer et al.
Yan Han et al.
Neonatal airway development and injury is poorly understood, in part due to challenges of studying extremes of phenotype in human pathologic samples and difficulties obtaining relevant comparator samples. Ex vivo model systems are needed to...
Sex Chromosomes and Gonadal Sex Interactions in Airway and Immune Responses to Allergen Challenge [0.03%]
性染色体和生殖腺性别在空气道及免疫系统对过敏原刺激反应中的相互作用
Carolyn Damilola Ekpruke,Dustin Rousselle,Rachel Alford et al.
Carolyn Damilola Ekpruke et al.
Asthma is a chronic respiratory condition influenced by genetic, environmental, and sex-related factors. Women experience greater asthma severity, airway hyperresponsiveness (AHR), and inflammation than men, likely due to sex-linked genetic...
Platelet-Mast Cell Dialogue in Innate Immune Response and Inflammation [0.03%]
先天免疫反应和炎症中的血小板-肥大细胞对话
Saptarshi Roy,Pawan Sharma
Saptarshi Roy
Emerging evidence identifies platelets as active participants in inflammation beyond their traditional hemostatic function. Mast cells, tissue-resident granulocytes, are key players in innate immunity. Recent studies reveal dynamic bidirect...
Contact-compression induces inflammatory and remodeling responses in bronchial epithelial cells [0.03%]
接触压缩诱导气道上皮细胞的炎症和重塑反应
Akash Gupta,Janette K Burgess,Theo Borghuis et al.
Akash Gupta et al.
Aims and objectives: Lung implantable devices such as stents and valves are used for treatment of lung cancer and COPD. They apply continuous supraphysiological compressive stress to airway tissue, potentially triggering adverse effects suc...