Structural and Molecular Alterations in Lung Lymphatic Endothelial Cells Induced by Cigarette Smoking: Insights and Emerging Hypotheses for Vaping [0.03%]
Hoda Raimi,Jiwon Hong,Victor Maldonado Zimbron et al.
Hoda Raimi et al.
Pulmonary lymphatics play multiple essential roles in lung homeostasis through interstitial fluid removal, traffic of immune cells, and antigen presentation. This highly branching vascular bed comprises initial capillaries, pre-collecting v...
Isabelle Dupin,Maël Lemoine
Isabelle Dupin
A subset of long-term smokers remain free of chronic obstructive pulmonary disease (COPD) or lung cancer, a phenomenon termed "lung resilience". Understanding this resilience could reveal protective mechanisms that preserve respiratory heal...
The Pyruvate Kinase Activator Etavopivat (FT-4202) Limits Pulmonary and Systemic Sequelae of Sepsis in a Mouse LPS Model [0.03%]
Youwei Chen,Hongmei Zhu,Lisheng Zhang et al.
Youwei Chen et al.
Sepsis is frequently characterized by abnormal O2 uptake by red blood cells (RBCs) in the lung and/or dysregulated tissue O2 delivery by RBCs. New approaches are needed to improve O2 transport and clinical outcomes in sepsis with or without...
Regenerative and Repair Roles of Alveolar Epithelial Cells Following Lung Injury [0.03%]
肺损伤后肺泡上皮细胞的再生和修复作用
Akira Yamagata,Anthea Weng
Akira Yamagata
The alveolar epithelium, composed of type 1 (AT1) and type 2 (AT2) cells, is central to gas exchange and the lung's response to injury. Historically viewed as a simple barrier, recent advances have unveiled the profound dynamics and plastic...
The role of S100A8/A9 in the pathogenesis of acute exacerbations of pulmonary fibrosis [0.03%]
S100A8/A9在肺纤维化急性加重中的作用机制研究
Naoki Nakamura,Hisao Higo,Satoru Senoo et al.
Naoki Nakamura et al.
Acute exacerbation of idiopathic pulmonary fibrosis is a life-threatening condition characterized by neutrophilic inflammation. S100A8/A9, an alarmin released by activated neutrophils and monocytes/macrophages, plays a pivotal role in regul...
Fibroblast crosstalk promotes mucin synthesis by COPD-derived airway epithelial cells [0.03%]
成纤维细胞的相互作用通过COPD源气道上皮细胞合成粘蛋白促进作用
Hataitip Tasena,Brady Rae,Maarten van den Berge et al.
Hataitip Tasena et al.
Chronic mucus hypersecretion (CMH) is a common feature of chronic obstructive pulmonary disease (COPD). One of the major factors contributing to CMH is excessive mucin release by the airway epithelium. We hypothesized that fibroblasts suppo...
Pseudomonas aeruginosa Exoenzyme Y Activity Inhibits Exoenzyme S-Induced Caspase Activation in Pulmonary Microvascular Endothelial Cells [0.03%]
铜绿假单胞菌外源酶Y活性抑制外源酶S诱导的肺微血管内皮细胞半胱天冬酶活化
Connor E Holm,Andrea Vavrinek,Sarah L Sayner et al.
Connor E Holm et al.
Pseudomonas aeruginosa is the most common cause of ventilator associated pneumonia in intensive care unit patients. Virulent P. aeruginosa strains utilize a type III secretion system that injects exoenzymes S, T, U and/or Y into the host ce...
Standardized pipeline for establishing, expanding, and differentiating airway and alveolar organoids from human BAL fluid [0.03%]
基于人体BAL液建立、扩增和分化气道和肺泡类器官的标准化流程
Taryn B Gellner,Belinda Chen,Shreyas R Raini et al.
Taryn B Gellner et al.
Lung organoids are versatile experimental models, but their broader use in studying human disease is limited by the scarcity of starting material and the complexity of current methods. To align organoid technology with common clinical pract...
Differential Effects of α7nAChR Activation in a Murine Model of Asthma [0.03%]
α7nAChR激活在哮喘小鼠模型中不同效应的研究
Niyati A Borkar,Kenge K Lee,Michael A Thompson et al.
Niyati A Borkar et al.
Nicotine, a primary component of tobacco, cigarette smoke and miscellaneous vaping products, can significantly impact respiratory health. Nicotine can exacerbate asthma through its actions on multiple cell types in airways. In this context,...
3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells [0.03%]
3-巯基丙酮酸硫转移酶（MPST）通过调节新生儿患者来源的呼吸道细胞的线粒体代谢和上皮分化发挥作用
Abhrajit Ganguly,Cynthia M Carter,Aristides Rivera Negron et al.
Abhrajit Ganguly et al.
Early-life airway epithelial development relies on tightly coordinated mitochondrial metabolic programs, yet the pathways that govern normal epithelial maturation during this vulnerable developmental window remain poorly defined. Hyperoxia ...