The non-steroidal MR antagonist Finerenone reverses Western diet-induced kidney disease by regulating mitochondrial and lipid metabolism and inflammation [0.03%]
非甾体MR拮抗剂Finerenone通过调节线粒体和脂质代谢及炎症逆转西方饮食引起的肾脏疾病
Komuraiah Myakala,Xiaoxin X Wang,Nataliia Shults et al.
Komuraiah Myakala et al.
Mineralocorticoid receptor (MR) overactivation plays a crucial role in the pathogenesis of chronic kidney disease, as well as several cardiovascular and arterial diseases. Current studies determined the mechanisms of the beneficial kidney e...
Jessica A Dominguez Rieg,Louise Nyrup Odgaard,Jianxiang Xue et al.
Jessica A Dominguez Rieg et al.
Transport across cells of the renal tubule differs between females and males, possibly as a consequence of varying abundance of transport proteins along the nephron. We hypothesized that sex-specific differences in the physiological respons...
Hung Nguyen,Nha Van Huynh,Kelly A Hyndman
Hung Nguyen
Aquaporins (AQPs) are a family of water channels found throughout the body and in the kidney, they function in maintaining water homeostasis. The insertion of AQPs into the plasma membrane of the kidney cells drives water reabsorption back ...
Underlying Metabolic Syndrome Exacerbates Vibrio vulnificus- induced Acute Kidney Injury via Systemic Th17/Treg Dysregulation [0.03%]
代谢综合征通过全身性Th17/Treg免疫失衡加重霍乱弧菌所致急性肾损伤
Madhura Pravin More,Punnag Saha,Subhajit Roy et al.
Madhura Pravin More et al.
Climate change has led to a rise in Vibrio vulnificus infections, while the global obesity epidemic has increased susceptibility to severe bacterial infections. Obesity and high-fat diet (HFD) consumption promote systemic inflammation and i...
A Key Role of AT1a Receptors and Na+/H+ Exchanger 3 in The Proximal Tubules in Angiotensin II-induced and Two-Kidney, One-Clip Goldblatt Hypertension [0.03%]
Ang II及Goldblatt高血压大鼠近曲小管AT1a受体和Na+/H+交换子3的参与作用
Xiao Chun Li,Rumana Hassan,Jia L Zhuo
Xiao Chun Li
The present study tests the hypothesis that dual deletion of AT1a receptors and NHE3 selectively in the proximal tubules further attenuates angiotensin II (Ang II)-induced and two-kidney, one-clip (2K1C) Goldblatt Hypertension. Proximal tub...
Therapeutic Potential of Tubular Serine Protease Inhibitors in Proteinuria [0.03%]
针对蛋白尿的管型丝氨酸蛋白酶抑制剂的治疗潜力
Mette Boye Boes,Per Svenningsen,Gitte Rye Hinrichs et al.
Mette Boye Boes et al.
Proteinuria is both a predictor and mediator of chronic kidney disease (CKD) progression, but treatment options targeting its underlying mechanisms are limited. Emerging evidence suggests that aberrantly filtered serine proteases contribute...
Sorting nexins associated with recycling complexes regulate epithelial sodium channel trafficking [0.03%]
与膜循环复合物相关联的分拣衔接蛋白调节上皮钠通道的作用形式和转运
Monique L Scott,Tanya T Cheung,Matthew J E Logue et al.
Monique L Scott et al.
In the kidney, the epithelial sodium channel (ENaC) facilitates sodium absorption in polarized epithelia and is required to maintain salt and water homeostasis. ENaC's apical membrane population is strictly controlled, with loss of this con...
Shun Kishimoto,Kazumasa Horie,Nallathamby Devasahayam et al.
Shun Kishimoto et al.
Renal oxygenation is essential for maintaining kidney function. Disruptions in oxygen delivery can lead to renal hypoxia, which can exacerbate kidney injury through multiple pathways, including inflammation, oxidative stress, and ischemia-r...