Characterization and Classification of Chronic Kidney Disease by Spatial MIST and Deep Learning Algorithm [0.03%]
基于空间MIST和深度学习算法的慢性肾脏病的特征及分类
Arafat Meah,Nehaben A Gujarati,Vivette D D&#x;Agati et al.
Arafat Meah et al.
Chronic kidney disease (CKD) is characterized by disruption of the native kidney architecture at the cellular and molecular levels, leading to eventual kidney fibrosis. To better resolve the spatial complexity of fibrotic remodeling, we app...
Null mutation of the p67phox subunit of NOX2 permits compensatory changes in renal blood flow during the development of salt sensitive hypertension in SS rats [0.03%]
NOS2(p67(phox))基因缺陷通过肾血流的代偿性变化影响SS大鼠盐敏感性高血压的发展
Louise C Evans,Alex Dayton,Terry Kurth et al.
Louise C Evans et al.
In the current study, we used SSp67phox-/- to assess the involvement of oxidative stress in the regulation of renal blood flow during the development of salt-sensitive hypertension in Dahl salt-sensitive (SS) rats. We performed continuous a...
Renal tubular (pro)renin receptor deletion exacerbates kidney injury in db/db mice [0.03%]
肾小管(pro)肾素受体的缺失加重db/db小鼠的肾脏损伤
Deborah Stuart,Caitlin S Peterson,Dhruvan Gopinath et al.
Deborah Stuart et al.
The (pro)renin receptor (PRR) is a multifunctional protein implicated in blood pressure regulation and kidney fibrosis. Previous studies report enhanced PRR expression in non-diabetic and diabetic kidney disease. In this study, we investiga...
Amanda J Clark,Brenda Mendoza Flores,Marie Christelle Saade et al.
Amanda J Clark et al.
Background: Acute Kidney Injury (AKI) is prevalent among hospitalized patients. Novel biomarkers are needed to diagnose AKI and target therapies. Endotrophin (ETP) is a molecule released during collagen type VI formation that may promote in...
Regional metabolic analysis of structurally preserved kidney slices by ex vivo respirometry [0.03%]
离体呼吸法检测结构保存的肾切片的区域代谢状况
Ryoichi Bessho,Olena Davidoff,Hanako Kobayashi et al.
Ryoichi Bessho et al.
A comprehensive spatial analysis of kidney metabolism is essential for advancing knowledge of both normal kidney physiology and pathophysiology. The kidney exhibits marked regional differences in bioenergetic demands and substrate utilizati...
5-hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice [0.03%]
小鼠5-羟色胺1F受体丢失减少肾血管并防止在中重度急性肾脏损伤后lasmiditan诱导的恢复
Austin D Thompson,Kai W McAlister,Natalie E Scholpa et al.
Austin D Thompson et al.
Kidney disease (KD) has emerged as a major global health crisis and leading cause of morbidity and mortality worldwide, impacting over 850 million individuals. Pathophysiological hallmarks of KD encompass renal tubular cell injury/necrosis,...
Pregnane X receptor (PXR) increases urine concentration by upregulating hypothalamic arginine vasopressin expression [0.03%]
孕烷X受体(PXR)通过上调下丘脑血管加压素表达来增加尿液浓缩能力
Xiaowan Sun,Ruifen Li,Zhilin Luan et al.
Xiaowan Sun et al.
The pregnane X receptor (PXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PXR is constitutively expressed in the hypothalamus and kidney, with its physiological function incompletely understo...
Shaza Khan,Lihe Chen,Chung-Lin Chou et al.
Shaza Khan et al.
Arginine vasopressin (AVP) is a peptide hormone synthesized in the hypothalamus and secreted by the posterior pituitary. Previous studies toward understanding of AVP physiology relied heavily on Brattleboro rats, which have a spontaneous mu...
Decreased parietal epithelial cell density is linked to podocyte depletion and predictors of kidney disease progression in human kidneys [0.03%]
视网膜上皮细胞密度降低与人肾脏系膜增生和肾病进展预测因素有关
Jenna T Ference-Salo,Christopher L O&#x;Connor,Rajasree Menon et al.
Jenna T Ference-Salo et al.
Parietal epithelial cells (PECs) have been implicated in the pathogenesis of glomerulosclerosis in rodent models, and novel technologies are beginning to unravel their contributions to human glomerular disease. Here we report the developmen...
Madison Williams,Brooke O&#x;Donnell,Linda Columbus et al.
Madison Williams et al.
Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney dis...