Ad Libitum Drinking Does Not Mitigate Acute Kidney Injury Risk nor Elevations in Oxidative Stress or Inflammation during Simulated Occupational Heat Stress [0.03%]
随意饮水无法缓解模拟职业性热应激下的急性肾损伤风险及氧化应激或炎症反应的增加
Erica Tourula,M Jo Hite,Molly E Heikkinen et al.
Erica Tourula et al.
This study tested the hypothesis that ad libitum fluid intake during a two-hour occupational heat stress simulation attenuates increases in renal oxidative stress, inflammation, and acute kidney injury (AKI) risk compared to fluid restricti...
New insight into plasma and organelle membrane repair to guard against cell death in tubular epithelium after acute kidney injury [0.03%]
急性肾损伤后管状上皮细胞血浆和细胞器膜修复新机制保障细胞存活
Si-Meng Wang,Ning Li,Wei-Wei Qian et al.
Si-Meng Wang et al.
Plasma membrane repair is crucial for resealing membrane disruptions from physiological and pathological stimuli to preserve cell integrity and homeostasis. Tubular epithelial cells (TECs) die of unrepaired membrane injury induced by bioche...
Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis and interstitial fibrosis in diabetic kidney disease [0.03%]
髓系细胞中脾酪氨酸激酶信号促进糖尿病肾病中巨噬细胞浸润、肾小球硬化和间质纤维化
Xiu Xian Chia,Elyce Ozols,David J Nikolic-Paterson et al.
Xiu Xian Chia et al.
Macrophages have been implicated in causing renal injury in diabetic kidney disease (DKD). Spleen tyrosine kinase (Syk) plays an important role in signaling via a number of cell surface receptors that promote recruitment and activation of m...
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN [0.03%]
雷帕霉素复合体2(mTORc2)介导高钾水处理对DCT中Kir4.1和ASDN中ENaC/ROMK的作用机制
Xin-Peng Duan,Jun-Ya Zheng,Chengbiao Zhang et al.
Xin-Peng Duan et al.
We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule (early-CNT). Also, we explore whether mT...
Maresin 1 Modulates Renal and Cardiac Lipid Profiles in Hypertensive Rats [0.03%]
maresin 1调节高血压大鼠的肾脏和心脏脂质谱型
Ruslan Bohovyk,Olha Kravtsova,Gunjan Upadhyay et al.
Ruslan Bohovyk et al.
Chronic inflammation contributes significantly to hypertension and associated target organ damage, particularly in the heart and kidneys. Specialized pro-resolving mediators, a class of bioactive lipids, play key roles in resolving inflamma...
Short-term hypothyroidism impairs the daily oscillations of renal circadian clock and function in a sex-dependent manner [0.03%]
短期甲状腺功能减退以性别依赖的方式损害肾脏生物钟的昼夜振荡及其功能
Derrick Kretli-Souza,Bruno Henrique Gomes,Letícia Selvatici-Tolentino et al.
Derrick Kretli-Souza et al.
Hypothyroidism is associated with the desynchronization of central and peripheral circadian clocks; however, its effects on renal rhythmicity remain unclear. This study investigated the impact of short-term hypothyroidism on renal molecular...
The endocytic adaptor ARH facilitates potassium conservation by regulating ROMK and BK [0.03%]
内吞衔接蛋白ARH通过调节ROMK和BK的作用促进钾保存
Lama Al-Qusairi,Ava M Zapf,Dimin Li et al.
Lama Al-Qusairi et al.
Renal Outer Medullary K+ (ROMK) channels are essential for urinary potassium secretion, and their endocytosis prevents excessive K+ loss during dietary deficiency. The clathrin adaptor ARH (Autosomal Recessive Hypercholesterolemia) has been...
Uremic Serum Exposure Leads to Differential Phenotypic Switch in Porcine Arterial and Venous Smooth Muscle Cells [0.03%]
尿毒症血清暴露导致猪动脉和静脉平滑肌细胞表型差异转换
Huanjuan Su,Unimunkh Uriyanghai,Christine Wai et al.
Huanjuan Su et al.
Many end-stage kidney disease (ESKD) patients frequently suffer from both aggressive vascular access stenosis in the venous segment of arteriovenous fistula or arteriovenous graft, and widespread cardiovascular disease (CVD) or peripheral a...