Protein Phosphatase 2A Subunit B55 Alpha is Required for Angiotensin Type 2 Receptor Elicited Natriuresis [0.03%]
蛋白磷酸酶2A亚基B55α是血管紧张素Ⅱ受体介导利钠排尿的必要条件
John J Gildea,Jie Li,Nancy L Howell et al.
John J Gildea et al.
Angiotensin type 2 receptor (AT2R) activation promotes natriuresis, thereby contributing to sodium balance and blood pressure regulation. In this study, we explored a novel intermediate in AT2R signaling, protein phosphatase 2A (PP2A) regul...
Population-Level Circadian Rhythm of eGFR and the Effect of Chronodisruption [0.03%]
基于人口的昼夜节律及生物钟紊乱对其影响：eGFR实例研究
Alfonso Luis Blázquez-Manzanera,Maria Carmen Lorenzo-Lozano,Irene Sánchez de Lara et al.
Alfonso Luis Blázquez-Manzanera et al.
Chronic kidney disease (CKD) is one of the leading causes of global morbidity, and early diagnosis is essential to prevent complications. Estimated glomerular filtration rate (eGFR) is a key biomarker for assessing renal function. However, ...
Physical association of NHE3 and SGLT2 mediated by accessory proteins in the renal proximal tubule [0.03%]
近曲小管中NHE3和SGLT2通过辅助蛋白介导的物理相互作用
Juliano Zequini Polidoro,Nádia Osório de Oliveira,Erika F Jesus et al.
Juliano Zequini Polidoro et al.
Proximal tubule NHE3 is tightly regulated by factors controlling extracellular volume homeostasis, blood pressure, and acid-base balance. Emerging evidence suggests that glycemic control-related factors also influence NHE3, supporting the c...
Chronic circadian stress impairs blood pressure and sodium homeostasis in a diet- and sex-specific manner [0.03%]
慢性昼夜节律压力以饮食和性别特定的方式损害血压和钠稳态
Mary N Latimer,Megan K Rhoads,Lance Dylan Reynolds et al.
Mary N Latimer et al.
This study investigates the effects of environmental circadian disruption and high-fat diet (HFD) on cardiovascular and renal functions in Bmal1 knockout (KO) and wild-type (WT) rats. Under 12:12 light:dark conditions, Bmal1 KO males and fe...
ENDOTHELIAL DYSFUNCTION ACCELERATES AKI TO CKD TRANSITION BY PROMOTING β-CATENIN ACTIVATION IN MACROPHAGES [0.03%]
内皮功能障碍通过促进巨噬细胞中β-catenin活化来加速AKI向CKD的转变
Masanobu Takasu,Seiji Kishi,Hajime Nagasu et al.
Masanobu Takasu et al.
Acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD), resulting in long-term renal dysfunction. While traditional risk factors such as hypertension, diabetes, and aging contribute to this transition, endothelial d...
SGLT-2 inhibitors attenuate pattern recognition molecules collectin kidney 1 and mannose-binding lectin in kidney and liver in mice with diabetes [0.03%]
糖尿病小鼠中钠葡萄糖协同转运蛋白-2抑制剂可减轻模式识别分子collectin肾素1和甘露聚糖结合凝集素在肾脏和肝脏中的聚集作用
Mia Jensen,Steffen Thiel,Søren W K Hansen et al.
Mia Jensen et al.
Background: SGLT-2 inhibitors improve outcomes in diabetic nephropathy (DN) and cardiovascular disease. To elucidate the underlying protective mechanisms, we explored the hypothesis that the lectin complement pathway, specifically through c...
AutoGlom: Software Tool for Segmentation and Analysis of Magnetic Resonance Images of the Kidney [0.03%]
自动分割和分析肾脏磁共振图像的软件工具
Teng Li,Adam Cochran,Yanzhe Xu et al.
Teng Li et al.
Magnetic resonance imaging (MRI) is increasingly important in preclinical and clinical investigations of the kidney. However, there are few user-friendly, flexible, and standardized tools for evaluating MR images for quantitative imaging an...
Iron Metabolism and Ferroptosis: Druggable Targets to Delay the Progression of Lupus Nephritis [0.03%]
铁代谢与铁死亡：延缓 lupus nephritis 进展的药物治疗靶点
Leena Al-Hraki,Laurence Morel,Yogesh Scindia
Leena Al-Hraki
Lupus nephritis (LN) is the renal manifestation of the autoimmune diseases Systemic lupus erythematosus (SLE). LN is characterized by a dysregulated immune system, presence of autoantibodies and renal immune complex deposits which collectiv...
Macrophages and TGFB Signaling Regulate Fibrosis in the E. coli-Infected Mouse Prostate [0.03%]
大肠杆菌感染的小鼠前列腺纤维化受巨噬细胞和TGFB信号通路的调节
Brandon R Scharpf,Jaskiran Sandhu,Hannah Ruetten et al.
Brandon R Scharpf et al.
Prostate inflammation and fibrosis are linked to lower urinary tract symptoms (LUTS) in men. Uropathogenic Escherichia coli (E. coli) infection of the mouse prostate triggers a cascade of immune responses that drive inflammation and fibrosi...