Xinge Wang,Haiping Hu,Qiang Wang et al.
Xinge Wang et al.
Despite advances in drug delivery technologies, there is still an unmet demand for non-invasive kidney-targeted drug delivery systems that enhance therapeutic efficacy while minimizing systemic side effects. In the present study, we conduct...
Processing of ENaC in mouse kidney: Effects of aldosterone and a Liddle syndrome mutation [0.03%]
醛固酮和Liddle综合征突变对鼠肾NaPC通道的影响
Gustavo Frindt,Lei Yang,Theresa Rohan et al.
Gustavo Frindt et al.
We investigated the interplay between the mineralocorticoid aldosterone and a mutation mimicking Liddle syndrome in the control of the processing of the epithelia Na+ channel (ENaC) in mouse kidneys. Rates of processing were assessed by the...
The response to kidney injury is epigenetically regulated through the activation of bivalent genes [0.03%]
肾脏损伤的反应通过激活双组蛋白标记基因而受到表观遗传调控
Benjamin I Tickman,Jacquelyn R McDonald,Ryan McCarthy et al.
Benjamin I Tickman et al.
Epigenetic regulation through histone modifications plays a crucial role in driving cellular state transitions. Regulating gene transcription through bivalency, the co-occurrence of activating H3K4me3 and repressive H3K27me3 histone marks, ...
Protective Effects of Fermentable Dietary Fiber and Propionate in Dahl Salt-Sensitive Hypertension and Renal Damage [0.03%]
可发酵膳食纤维和丙酸对Dahl盐敏感性高血压及肾损害的保护作用
Samuel D Walton,John Henry Dasinger,Emily C Burns-Ray et al.
Samuel D Walton et al.
The Dahl Salt-Sensitive (SS) rat is an established model of hypertensive kidney injury, where the gut microbiota has been shown to causally contribute to disease progression. Gut bacteria-derived metabolites serve as mechanistic links betwe...
Rapid Podocyte Loss in Murine Models Triggers the Formation of Podocyte-Parietal Epithelial Cell Intercellular Bridges [0.03%]
小鼠模型中的足细胞快速丢失触发足细胞和系膜细胞间桥的形成
Nina Cintron Pregosin,Yiqing Guo,Emily T Dang et al.
Nina Cintron Pregosin et al.
Podocytes are highly specialized terminally differentiated visceral epithelial cells that are critical for the maintenance of the glomerular filtration barrier. In subtypes of glomerulonephritis and focal segmental glomerulosclerosis (FSGS)...
Pendrin is Upregulated by Corticosterone and Participates in its Pressor Response [0.03%]
皮质酮诱导 pendrin 表达并参与其升压反应
Truyen D Pham,Delaney C Abood,Eric Delpire et al.
Truyen D Pham et al.
NaCl restriction upregulates pendrin, in part, through increased circulating aldosterone and the intercalated cell (IC) mineralocorticoid receptor (MR). Since 11 HSD2 enhances aldosterone binding to this receptor in other cells, we asked i...
Obesity enhances salt-sensitivity of blood pressure, independent of skin electrolytes, and more in female than in male ZSF1 rats [0.03%]
肥胖通过独立于皮肤电解质的方式增强血压的盐敏感性，在ZSF1大鼠中雌性的增幅大于雄性
Isabel T N Nguyen,Olav Tenstad,Anne-Maj Samuelsson et al.
Isabel T N Nguyen et al.
Obesity and sex influence the salt-sensitivity of blood pressure, but it is unknown whether this also affects tissue electrolyte accumulation. We hypothesized that obese female rats exhibit greater salt-sensitivity of blood pressure with hi...
The Association between Extracellular Fluid Volume and Sympathetic Nervous System Activity in Patients with Chronic Kidney Disease [0.03%]
慢性肾脏病患者细胞外液容量与交感神经系统活性的关系
Jinhee Jeong,Kanokwan Bunsawat,Jeann L Sabino-Carvalho et al.
Jinhee Jeong et al.
Introduction. Chronic kidney disease (CKD) is associated with hypervolemia and sympathetic nervous system (SNS) overactivity that both contribute to heightened cardiovascular risk. Classically, extracellular fluid volume (ECFV) is inversely...
Dynamic and differential renal cortical cell-specific mitochondrial metabolism in response to fasting [0.03%]
肾脏皮质细胞特异性线粒体代谢的动态及差异性响应饥饿诱导
Kyle Feola,Andrea Henning Venable,Mina Rasouli et al.
Kyle Feola et al.
The metabolic health of the kidney is directly correlated to the risk of progressive kidney disease. Our understanding of the metabolic processes that fuel the diverse functions of the kidney is limited by the kidney's structural and functi...