Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells [0.03%]
Krüppel样因子2调节成熟血管近球细胞的肾素表达
Hiroki Yamaguchi,Jason P Smith,Omar Guessoum et al.
Hiroki Yamaguchi et al.
Renin regulates blood pressure and fluid-electrolyte homeostasis via the renin-angiotensin-aldosterone system (RAAS), and renin cells function as renal baroreceptors that couple perfusion pressure to renin output. Krüppel-like factor 2 (Kl...
Yuting Zeng,Robert Allen Schweickart,Jana Sharara et al.
Yuting Zeng et al.
Although injury in glomerular disease might only damage a subset of podocytes in any given glomerulus, the response of the healthy neighboring podocytes to the injured podocytes oftentimes determines the course of the disease. To investigat...
Kidney kallikrein-1 contributes to cleavage of gamma-ENaC in vivo [0.03%]
肾脏胰蛋白酶前体kallikrein-1对体内γ-ENaC的裂解有贡献
Joshua Curry,Xiao-Tong Su,Qi Wu et al.
Joshua Curry et al.
The epithelial sodium channel (ENaC) is essential for sodium reabsorption and potassium homeostasis in the distal nephron, where its activity is controlled by mineralocorticoid signaling and downstream proteolytic processing of channel subu...
Making a portal for podocyte - parietal cell communication in glomerular injury [0.03%]
构建足细胞-壁层上皮细胞通讯通道以治疗肾小球损伤
Leslie A Bruggeman
Leslie A Bruggeman
Vascular transcriptional and metabolic changes precede progressive intra-renal microvascular rarefaction in autosomal dominant polycystic kidney disease [0.03%]
常染色体显性多囊肾病进展性肾内微血管稀疏的血管转录组及代谢改变
Gizem Yilmaz,Santu K Singha,Bansi Savaliya et al.
Gizem Yilmaz et al.
Background: The mechanisms contributing to progressive kidney damage in autosomal dominant polycystic kidney disease (ADPKD) remain unclear. Renal microvascular (MV) rarefaction plays an important role in kidney disease, but its natural his...
The Transcription Factor TCF21 is Necessary for Adoption of Cell Fates by Foxd1+ Stromal Progenitors during Kidney Development [0.03%]
转录因子TCF21是肾发育过程中Foxd1+间充质干细胞采取细胞命运的必要因素
Gal Finer,George S Yacu,Mohammad Daud Khan et al.
Gal Finer et al.
The stromal compartment of the developing kidney arises from Foxd1-expressing progenitors and gives rise to diverse cell types essential for nephrogenesis, including the renal stroma, capsule, mesangial cells, renin cells, pericytes, and va...
Hedgehog Pathway Disruption Alters Urothelial Differentiation and Continence Mechanisms in the Female Mouse Lower Urinary Tract [0.03%]
刺猬信号通路的破坏扰乱了雌性下尿路上皮分化和控尿机制
Lindsey Felth Tanaka,Julia Tlapa,Jack Morrison et al.
Lindsey Felth Tanaka et al.
Urinary incontinence (UI) imposes a significant healthcare burden and reduces quality of life. Contributing factors such as aging, pregnancy/childbirth, stress, and injury are recognized, but incomplete understanding of underlying mechanism...
Guido de La Roij,Robin H M van der Meijden,Luco Rutten et al.
Guido de La Roij et al.
Chronic kidney disease (CKD) is a risk factor for cardiovascular disease (CVD), partly due to phosphate-induced vascular calcification. Fetuin-A stabilizes calcium-phosphate complexes into calciprotein particles (CPPs), preventing precipita...
Loss of transcription factor ATOH8 activates TGF-β signaling and exacerbates glomerulosclerosis in podocytes [0.03%]
转录因子ATOH8的丢失激活TGF-β信号并加重足细胞中的系膜硬化病变
Hiroko Hamatani,Akifumi Tabei,Shinichiro Ogawa et al.
Hiroko Hamatani et al.
Atonal BHLH transcription factor 8 (ATOH8) is a basic helix-loop-helix (bHLH) transcription factor; however, its role in glomerular epithelial cells (podocytes) remains unclear. This study aimed to elucidate the function of ATOH8 in podocyt...