Ovarian Hormones Moderate Systolic Hypertension in Female Eln Haploinsufficient Mice [0.03%]
卵巢激素调节Eln半定量不足小鼠的女性高血压病情严重程度
Alethia J Dixon,Ipsita Mohanty,Gagandeep Kaur et al.
Alethia J Dixon et al.
Hypertension is a hallmark of cardiovascular abnormalities associated with Williams syndrome (WS), a rare genetic disorder involving microdeletion of genes on human chromosome 7, including the elastin gene (ELN). Heterozygous deletion of El...
Fibroblast histone deacetylase-1 promotes kidney interstitial fibrosis following ischemia-reperfusion injury [0.03%]
成纤维细胞组蛋白去乙酰化酶-1促进缺血再灌注损伤后肾脏间质纤维化
Huy Nguyen,Luciano D Mendoza,Ariana S Oliver et al.
Huy Nguyen et al.
Interstitial fibrosis is a hallmark of chronic kidney disease, and extracellular matrix is secreted by kidney fibroblasts/pericytes that have differentiated into myofibroblasts. Class I histone deacetylases (HDACs) are highly expressed in t...
Glomerular hyperfiltration and enhanced sensitivity to kidney ischemia reperfusion with a blunted KIM-1 response in young male aging-accelerated SAMP8 mice [0.03%]
SAMP8衰老加速小鼠肾缺血再灌注的肾小球高滤过及KIM-1反应减弱所致对肾脏损伤的敏感性增加
Helen A Goodluck,Sadhana Kanoo,Young Chul Kim et al.
Helen A Goodluck et al.
To better understand the impact of accelerated aging on kidney function, we compared standard C57BL6 mice (C57BL6) with Senescence Accelerated Mouse-Prone 8 mice (SAMP8). Young male SAMP8 (3&6 months) showed glomerular hyperfiltration compa...
Reproducing Human Diabetic Nephropathy in a Novel Obesity-Driven Animal Model [0.03%]
在新型肥胖驱动的动物模型中再现人类糖尿病肾病
Silvia Teixidó-Trujillo,Esteban Porrini,María Fernanda Toniolo et al.
Silvia Teixidó-Trujillo et al.
Diabetic nephropathy is a leading cause of end-stage kidney disease worldwide, yet its complex pathogenesis remains incompletely understood. This is partly due to limitations of existing preclinical models, which are often genotypic, monoge...
Acute Kidney Injury Biomarker Responses in Young and Older Female Adults Following Mild Hypohydration [0.03%]
轻度脱水后年轻和年长女性急性肾损伤生物标志物的反应
Christin Domeier,Austin T Robinson,Matthew C Babcock et al.
Christin Domeier et al.
Background: Hypohydration reduces kidney function and increases acute kidney injury (AKI) risk. Aging increases hypohydration-induced kidney dysfunction in males, but female aging studies are lacking. Therefore, we compared the effects of m...
Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression [0.03%]
激活法尼醇X受体抑制肾集合管细胞TMEM16A介导的氯离子分泌并延缓肾脏囊性病变进展
Nipitpon Srimai,Kanlayanee Tonum,Sanya Sureram et al.
Nipitpon Srimai et al.
The farnesoid X receptor (FXR) plays a role in the regulation of renal transporters and ion channels. Our previous study reported that activation of FXR inhibited cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl- secre...
NF-κB/Apaf1/caspase-9 Axis Suppresses Autophagy to Drive Tubular Inflammation and Apoptosis in Septic Acute Kidney Injury [0.03%]
NF-κB/Apaf1/caspase-9轴通过抑制自噬促进脓毒症急性肾损伤的管状炎症和细胞凋亡
Juan Wang,Zheng Li,Fei Peng et al.
Juan Wang et al.
Septic acute kidney injury (AKI) is a life-threatening complication of systemic infection, characterized by rapid loss of renal function and high mortality. Despite its clinical significance, the underlying molecular mechanisms remain incom...
Extracellular Vesicle Transcriptomes in Human Urine Capture Kidney Adaptation to Sodium Intake [0.03%]
人尿液细胞外囊泡转录组捕获肾脏对钠摄入的适应性响应
Iben Skov Jensen,Rikke Zachar,Boye L Jensen et al.
Iben Skov Jensen et al.
Urine extracellular vesicles (uEVs) originate from the genitourinary system, including the kidney's tubular epithelial cells. These cells control Na+ balance, e.g., by increased aldosterone-induced Na+ reabsorption in response to a low Na+ ...